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Article: Haematopoietic stem cell transplantation: Current concepts and novel therapeutic strategies

TitleHaematopoietic stem cell transplantation: Current concepts and novel therapeutic strategies
Authors
KeywordsGraft-versus-host disease
Haematopoietic stem cell transplantation
Mobilization
Reduced intensity conditioning
Umbilical cord blood
Issue Date2010
PublisherOxford University Press. The Journal's web site is located at http://bmb.oxfordjournals.org/
Citation
British Medical Bulletin, 2010, v. 93 n. 1, p. 85-103 How to Cite?
AbstractIntroduction: Haematopoietic stem cell transplantation (HSCT) is potentially curative for haematological diseases. New developments are improving its applicability and success. Sources of data: A literature search was conducted on peripheral blood haematopoietic stem cell (PBHSC) mobilization, umbilical cord blood (UCB) transplantation, reduced intensity conditioning (RIC) and acute graft-versus-host disease (aGVHD). Areas of agreement: PBHSC mobilization by granulocyte colony-stimulating factor and chemomobilization may fail in up to 30% of patients previously treated with extensive chemotherapy. New mobilization agents, notably the CXCR4 antagonist, have improved mobilization efficacy. UCB-HSCT is equally feasible in children and adults. RIC enables HSCT to be performed in patients who are elderly or with serious medical co-morbidities. RIC-HSCT is associated with increased frequency of graft failure and disease relapse. The prophylaxis and treatment of aGVHD are still problematic. Areas of controversy: Novel strategies in PBHSC mobilization, utilization of UCB-HSCT and RIC-HSCT and prophylaxis and treatment of aGVHD, have not been critically appraised or compared with conventional strategies. Areas timely for developing research: The safety and efficacy of novel mobilization agents have to be tested in normal allogeneic donors. Methods of increasing the cell dose or efficacy of UCB should be developed, to extend its use to adults. RIC-HSCT should be compared with conventional HSCT in young patients. Continuous efforts in defining the best prophylaxis and treatment of aGVHD should be made. © The Author 2009. Published by Oxford University Press. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/125027
ISSN
2015 Impact Factor: 2.921
2015 SCImago Journal Rankings: 1.391
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, AYHen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-10-31T11:07:23Z-
dc.date.available2010-10-31T11:07:23Z-
dc.date.issued2010en_HK
dc.identifier.citationBritish Medical Bulletin, 2010, v. 93 n. 1, p. 85-103en_HK
dc.identifier.issn0007-1420en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125027-
dc.description.abstractIntroduction: Haematopoietic stem cell transplantation (HSCT) is potentially curative for haematological diseases. New developments are improving its applicability and success. Sources of data: A literature search was conducted on peripheral blood haematopoietic stem cell (PBHSC) mobilization, umbilical cord blood (UCB) transplantation, reduced intensity conditioning (RIC) and acute graft-versus-host disease (aGVHD). Areas of agreement: PBHSC mobilization by granulocyte colony-stimulating factor and chemomobilization may fail in up to 30% of patients previously treated with extensive chemotherapy. New mobilization agents, notably the CXCR4 antagonist, have improved mobilization efficacy. UCB-HSCT is equally feasible in children and adults. RIC enables HSCT to be performed in patients who are elderly or with serious medical co-morbidities. RIC-HSCT is associated with increased frequency of graft failure and disease relapse. The prophylaxis and treatment of aGVHD are still problematic. Areas of controversy: Novel strategies in PBHSC mobilization, utilization of UCB-HSCT and RIC-HSCT and prophylaxis and treatment of aGVHD, have not been critically appraised or compared with conventional strategies. Areas timely for developing research: The safety and efficacy of novel mobilization agents have to be tested in normal allogeneic donors. Methods of increasing the cell dose or efficacy of UCB should be developed, to extend its use to adults. RIC-HSCT should be compared with conventional HSCT in young patients. Continuous efforts in defining the best prophylaxis and treatment of aGVHD should be made. © The Author 2009. Published by Oxford University Press. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://bmb.oxfordjournals.org/en_HK
dc.relation.ispartofBritish Medical Bulletinen_HK
dc.subjectGraft-versus-host diseaseen_HK
dc.subjectHaematopoietic stem cell transplantationen_HK
dc.subjectMobilizationen_HK
dc.subjectReduced intensity conditioningen_HK
dc.subjectUmbilical cord blooden_HK
dc.subject.meshGraft vs Host Disease - prevention and control-
dc.subject.meshHematopoietic Stem Cell Mobilization - methods - standards-
dc.subject.meshHematopoietic Stem Cell Transplantation - methods-
dc.subject.meshHumans-
dc.subject.meshTransplantation Conditioning - methods - standards-
dc.titleHaematopoietic stem cell transplantation: Current concepts and novel therapeutic strategiesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1420&volume=93&issue=1&spage=85&epage=103&date=2009&atitle=Haematopoietic+stem+cell+transplantation:+current+concepts+and+novel+therapeutic+strategiesen_HK
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityLeung, AYH=rp00265en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/bmb/ldp040en_HK
dc.identifier.pmid19900948-
dc.identifier.scopuseid_2-s2.0-77949387143en_HK
dc.identifier.hkuros180394en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949387143&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume93en_HK
dc.identifier.issue1en_HK
dc.identifier.spage85en_HK
dc.identifier.epage103en_HK
dc.identifier.isiWOS:000275565800006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, AYH=7403012668en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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