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Article: Determinants of peripheral blood count value in long-term survivors of allogeneic hemopoietic stem cell transplantation

TitleDeterminants of peripheral blood count value in long-term survivors of allogeneic hemopoietic stem cell transplantation
Authors
Issue Date2009
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3182
Citation
Hematological Oncology, 2009, v. 27 n. 2, p. 98-101 How to Cite?
AbstractHemopoeitic stem cell transplant (HSCT) recipients are monitored by regular complete blood picture (CBP). The reference ranges for acceptable values are undefined. We analysed the CBP in 228 stable HSCT survivors (median follow-up 103 months, range 60-212) without transplant-related medications and complications. Compared with donors, recipients had lower absolute neutrophil count (ANC) and platelet levels (Plt) and higher mean corpuscular volume (MCV), but comparable hemoglobin (Hb) and absolute lymphocyte count (ALC). There was significant donor-recipient correlation in all CBP parameters (Hb, ALC, ANC, MCV, Plt). Significant correlation was also found between levels of Hb, white cell and Plt among recipients. All counts were higher in patients with longer follow-up. Donor and recipient gender, age and underlying diagnosis can influence stable CBP values.We conclude that both host and marrow factors influence CBP values in stably engrafted recipients. 'Abnormal' CBP values deviating from that in normal populations may not have clinical significance. Copyright © 2009 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/125002
ISSN
2015 Impact Factor: 3.494
2015 SCImago Journal Rankings: 0.767
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPaul, KAen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorAu, WYen_HK
dc.date.accessioned2010-10-31T11:06:01Z-
dc.date.available2010-10-31T11:06:01Z-
dc.date.issued2009en_HK
dc.identifier.citationHematological Oncology, 2009, v. 27 n. 2, p. 98-101en_HK
dc.identifier.issn0278-0232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125002-
dc.description.abstractHemopoeitic stem cell transplant (HSCT) recipients are monitored by regular complete blood picture (CBP). The reference ranges for acceptable values are undefined. We analysed the CBP in 228 stable HSCT survivors (median follow-up 103 months, range 60-212) without transplant-related medications and complications. Compared with donors, recipients had lower absolute neutrophil count (ANC) and platelet levels (Plt) and higher mean corpuscular volume (MCV), but comparable hemoglobin (Hb) and absolute lymphocyte count (ALC). There was significant donor-recipient correlation in all CBP parameters (Hb, ALC, ANC, MCV, Plt). Significant correlation was also found between levels of Hb, white cell and Plt among recipients. All counts were higher in patients with longer follow-up. Donor and recipient gender, age and underlying diagnosis can influence stable CBP values.We conclude that both host and marrow factors influence CBP values in stably engrafted recipients. 'Abnormal' CBP values deviating from that in normal populations may not have clinical significance. Copyright © 2009 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3182en_HK
dc.relation.ispartofHematological Oncologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAnemia, Aplastic - blood - surgeryen_HK
dc.subject.meshBlood Cell Counten_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshGraft Survivalen_HK
dc.subject.meshHematopoietic Stem Cell Transplantation - statistics & numerical dataen_HK
dc.subject.meshHemoglobins - analysisen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukemia - blood - surgeryen_HK
dc.subject.meshLymphoma - blood - surgeryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshSurvivorsen_HK
dc.subject.meshTransplantation, Homologousen_HK
dc.subject.meshYoung Adulten_HK
dc.titleDeterminants of peripheral blood count value in long-term survivors of allogeneic hemopoietic stem cell transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-0232&volume=27&issue=2&spage=98–101&epage=&date=2009&atitle=Determinants+of+peripheral+blood+count+value+in+long-term+survivors+of+allogeneic+hemopoietic+stem+cell+transplantationen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hon.885en_HK
dc.identifier.pmid19248048-
dc.identifier.scopuseid_2-s2.0-66949156552en_HK
dc.identifier.hkuros180720en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-66949156552&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue2en_HK
dc.identifier.spage98en_HK
dc.identifier.epage101en_HK
dc.identifier.isiWOS:000267352100006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPaul, KA=26667228600en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK

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