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Article: Impaired serum capacity to induce cholesterol efflux is associated with endothelial dysfunction in type 2 diabetes mellitus

TitleImpaired serum capacity to induce cholesterol efflux is associated with endothelial dysfunction in type 2 diabetes mellitus
Authors
KeywordsEndothelial dysfunction
Reverse cholesterol transport
Serum cholesterol efflux capacity
Type 2 diabetes mellitus
Issue Date2009
PublisherSage Publications Ltd.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201955
Citation
Diabetes And Vascular Disease Research, 2009, v. 6 n. 4, p. 238-243 How to Cite?
AbstractObjective: Reverse cholesterol transport (RCT) plays a protective role against atherosclerosis and cholesterol efflux from cells is an early step in the RCT pathway. We investigated whether the capacity of serum to induce cholesterol efflux was associated with endothelial dysfunction in type 2 diabetes. Methods: Endothelium-dependent and -independent vasodilation of the brachial artery was measured by high-resolution vascular ultrasound and serum cholesterol efflux capacity was determined by measuring the transfer of [3H]cholesterol from Fu5AH cells to serum in 137 patients with type 2 diabetes and 75 controls. Results: Serum cholesterol efflux capacity was lower in diabetic patients than in the controls (13.6±2.5% vs. 14.6±3.4%, respectively, p=0.02), and both endothelium-dependent vasodilation (4.9±2.2% vs. 8.8±4.1%, respectively, p<0.01) and endothelium-independent vasodilation were impaired (13.4±4.3% vs. 16.3±5.5%. respectively, p<0.01). Endothelium-dependent vasodilation correlated with serum cholesterol efflux capacity (r=0.26, p=0.003) in diabetic patients and controls (r=0.24, p=0.037). On general linear model analysis, the presence of diabetes, brachial artery diameter and serum cholesterol efflux capacity were significant independent determinants of endothelium-dependent vasodilation. Conclusion: Impaired serum cholesterol efflux capacity was associated with endothelial dysfunction independent of other cardiovascular risk factors. © The Author(s) 2009.
Persistent Identifierhttp://hdl.handle.net/10722/124990
ISSN
2015 Impact Factor: 3.035
2015 SCImago Journal Rankings: 1.204
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuali, Zen_HK
dc.contributor.authorShiu, SWMen_HK
dc.contributor.authorYing, Wen_HK
dc.contributor.authorTan, KCBen_HK
dc.date.accessioned2010-10-31T11:05:22Z-
dc.date.available2010-10-31T11:05:22Z-
dc.date.issued2009en_HK
dc.identifier.citationDiabetes And Vascular Disease Research, 2009, v. 6 n. 4, p. 238-243en_HK
dc.identifier.issn1479-1641en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124990-
dc.description.abstractObjective: Reverse cholesterol transport (RCT) plays a protective role against atherosclerosis and cholesterol efflux from cells is an early step in the RCT pathway. We investigated whether the capacity of serum to induce cholesterol efflux was associated with endothelial dysfunction in type 2 diabetes. Methods: Endothelium-dependent and -independent vasodilation of the brachial artery was measured by high-resolution vascular ultrasound and serum cholesterol efflux capacity was determined by measuring the transfer of [3H]cholesterol from Fu5AH cells to serum in 137 patients with type 2 diabetes and 75 controls. Results: Serum cholesterol efflux capacity was lower in diabetic patients than in the controls (13.6±2.5% vs. 14.6±3.4%, respectively, p=0.02), and both endothelium-dependent vasodilation (4.9±2.2% vs. 8.8±4.1%, respectively, p<0.01) and endothelium-independent vasodilation were impaired (13.4±4.3% vs. 16.3±5.5%. respectively, p<0.01). Endothelium-dependent vasodilation correlated with serum cholesterol efflux capacity (r=0.26, p=0.003) in diabetic patients and controls (r=0.24, p=0.037). On general linear model analysis, the presence of diabetes, brachial artery diameter and serum cholesterol efflux capacity were significant independent determinants of endothelium-dependent vasodilation. Conclusion: Impaired serum cholesterol efflux capacity was associated with endothelial dysfunction independent of other cardiovascular risk factors. © The Author(s) 2009.en_HK
dc.languageengen_HK
dc.publisherSage Publications Ltd.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201955en_HK
dc.relation.ispartofDiabetes and Vascular Disease Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsDiabetes and Vascular Disease Research. Copyright © Sage Publications Ltd..-
dc.subjectEndothelial dysfunctionen_HK
dc.subjectReverse cholesterol transporten_HK
dc.subjectSerum cholesterol efflux capacityen_HK
dc.subjectType 2 diabetes mellitusen_HK
dc.subject.meshBrachial Artery - physiopathology - ultrasonography-
dc.subject.meshCholesterol - blood-
dc.subject.meshDiabetes Mellitus, Type 2 - blood - physiopathology - ultrasonography-
dc.subject.meshEndothelium, Vascular - physiopathology - ultrasonography-
dc.subject.meshVasodilation-
dc.titleImpaired serum capacity to induce cholesterol efflux is associated with endothelial dysfunction in type 2 diabetes mellitusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1479-1641&volume=6&issue=4&spage=238&epage=243&date=2009&atitle=Impaired+serum+capacity+to+induce+cholesterol+efflux+is+associated+with+endothelial+dysfunction+in+type+2+diabetes+mellitus-
dc.identifier.emailTan, KCB:kcbtan@hku.hken_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1177/1479164109344934en_HK
dc.identifier.pmid20368217en_HK
dc.identifier.scopuseid_2-s2.0-70350164148en_HK
dc.identifier.hkuros174623en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350164148&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue4en_HK
dc.identifier.spage238en_HK
dc.identifier.epage243en_HK
dc.identifier.isiWOS:000270851400004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHuali, Z=14056199500en_HK
dc.identifier.scopusauthoridShiu, SWM=7005550652en_HK
dc.identifier.scopusauthoridYing, W=36191523800en_HK
dc.identifier.scopusauthoridTan, KCB=8082703100en_HK

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