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Article: T-cell large granular lymphocyte leukemia: An Asian perspective

TitleT-cell large granular lymphocyte leukemia: An Asian perspective
Authors
KeywordsNeutropenia
Pure red cell aplasia
Rheumatoid arthritis
Splenomegaly
T-cell large granular lymphocyte leukemia
Issue Date2010
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htm
Citation
Annals Of Hematology, 2010, v. 89 n. 4, p. 331-339 How to Cite?
AbstractTo characterize T-cell large granular leukemia in Asia, 22 Chinese patients from a single institute were reported, together with an analysis of 88 Asian and 272 Western patients identified from the literature. In our cohort, anemia due to pure red cell aplasia (PRCA) occurred in 15/22 (68%) of cases, being the most common indication for treatment. Neutropenia was only found in 8/ 22 (36%) cases, and recurrent infections, the most important clinical problem in Western patients, were not observed. None of our cases presented with rheumatoid arthritis. These clinical features were consistently observed when compared with the 88 other Asian patients. Combined data from our cohort and other Asian cases showed that Asian patients, compared with Western patients, had more frequent anemia (66/110, 60% versus 113/240, 47%; p=0.044), attributable to a much higher incidence of PRCA (52/110, 47% versus 6/143, 4%; p<0.001). However, Western patients presented more frequently than Asian patients with neutropenia (146/2 5, 62% versus 33/110, 30%; p<0.001) and splenomegaly (99/246, 40% versus 16/110, 15%; p<0.001). Notably, Western patients were about eight to ten times more likely than Asian patients to have rheumatoid arthritis (73/272, 27% versus 4/106, 4%; p<0.001) and recurrent infections (81/272, 30% versus 3/107, 3%; p< 0.001). These clinicopathologic differences have important implications on disease pathogenesis and treatment.© Springer-Verlag 2010.
Persistent Identifierhttp://hdl.handle.net/10722/124984
ISSN
2015 Impact Factor: 3.022
2015 SCImago Journal Rankings: 1.117
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorLeung, AYHen_HK
dc.contributor.authorTse, EWCen_HK
dc.date.accessioned2010-10-31T11:05:02Z-
dc.date.available2010-10-31T11:05:02Z-
dc.date.issued2010en_HK
dc.identifier.citationAnnals Of Hematology, 2010, v. 89 n. 4, p. 331-339en_HK
dc.identifier.issn0939-5555en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124984-
dc.description.abstractTo characterize T-cell large granular leukemia in Asia, 22 Chinese patients from a single institute were reported, together with an analysis of 88 Asian and 272 Western patients identified from the literature. In our cohort, anemia due to pure red cell aplasia (PRCA) occurred in 15/22 (68%) of cases, being the most common indication for treatment. Neutropenia was only found in 8/ 22 (36%) cases, and recurrent infections, the most important clinical problem in Western patients, were not observed. None of our cases presented with rheumatoid arthritis. These clinical features were consistently observed when compared with the 88 other Asian patients. Combined data from our cohort and other Asian cases showed that Asian patients, compared with Western patients, had more frequent anemia (66/110, 60% versus 113/240, 47%; p=0.044), attributable to a much higher incidence of PRCA (52/110, 47% versus 6/143, 4%; p<0.001). However, Western patients presented more frequently than Asian patients with neutropenia (146/2 5, 62% versus 33/110, 30%; p<0.001) and splenomegaly (99/246, 40% versus 16/110, 15%; p<0.001). Notably, Western patients were about eight to ten times more likely than Asian patients to have rheumatoid arthritis (73/272, 27% versus 4/106, 4%; p<0.001) and recurrent infections (81/272, 30% versus 3/107, 3%; p< 0.001). These clinicopathologic differences have important implications on disease pathogenesis and treatment.© Springer-Verlag 2010.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htmen_HK
dc.relation.ispartofAnnals of Hematologyen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectNeutropeniaen_HK
dc.subjectPure red cell aplasiaen_HK
dc.subjectRheumatoid arthritisen_HK
dc.subjectSplenomegalyen_HK
dc.subjectT-cell large granular lymphocyte leukemiaen_HK
dc.subject.meshAntineoplastic Agents - therapeutic use-
dc.subject.meshCohort Studies-
dc.subject.meshHong Kong - epidemiology-
dc.subject.meshLeukemia, Large Granular Lymphocytic - diagnosis - drug therapy - epidemiology-
dc.subject.meshTreatment Outcome-
dc.titleT-cell large granular lymphocyte leukemia: An Asian perspectiveen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0939-5555&volume=89&issue=4&spage=331&epage=339&date=2010&atitle=T-cell+large+granular+lymphocyte+leukemia:+an+Asian+perspectiveen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_HK
dc.identifier.emailTse, EWC:ewctse@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityLeung, AYH=rp00265en_HK
dc.identifier.authorityTse, EWC=rp00471en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00277-009-0895-3en_HK
dc.identifier.pmid20084380-
dc.identifier.scopuseid_2-s2.0-77649300609en_HK
dc.identifier.hkuros180323en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77649300609&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume89en_HK
dc.identifier.issue4en_HK
dc.identifier.spage331en_HK
dc.identifier.epage339en_HK
dc.identifier.isiWOS:000274685400001-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridLeung, AYH=7403012668en_HK
dc.identifier.scopusauthoridTse, EWC=7005019454en_HK
dc.identifier.citeulike6838871-

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