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Article: Elevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease

TitleElevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease
Authors
KeywordsAdiponectin
C-reactive protein
Chronic obstructive pulmonary disease
Interleukin-6
Interleukin-8
Lung function
Issue Date2010
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
Citation
International Journal Of Tuberculosis And Lung Disease, 2010, v. 14 n. 9, p. 1193-1200 How to Cite?
AbstractBACKGROUND: Adiponectin is an anti-inflammatory adipokine that may play a role in chronic obstructive pulmonary disease (COPD) pathogenesis. OBJECTIVE: To investigate the relationship between adiponectin, interleukin (IL) 6, IL-8 and C-reactive protein (CRP) and COPD by evaluating these biomarkers in ever-smokers with or without the disease. METHOD: Plasma levels of adiponectin, IL-6, IL-8 and CRP were measured using commercially available kits in COPD patients (n = 71), healthy ever-smokers (n = 62) and non-smokers (n = 51). RESULTS: There were significant increases in plasma adiponectin, IL-6 and CRP in COPD patients (median [IQR] 4.39 μg/ml [2.68-6.98], 4.19 pg/ml [<2.40-6.40], 8.75 mg/l [4.26-40.63], respectively) compared to healthy ever-smokers (1.90 μg/ml [0.86-2.86], <2.40 pg/ml [<2.40-2.77], 3.71 mg/l [1.97-10.37 mg/l], respectively, P < 0.001) and non-smokers (1.76 μg/ml [1.34-2.52], <2.40 pg/ml [<2.40-2.78], 3.12 mg/l [2.11-5.71], respectively, P < 0.001). COPD patients had lower plasma IL-8 levels than healthy ever-smokers. Among ever-smokers with or without COPD, plasma adiponectin, IL-6 and CRP levels were inversely correlated with forced expiratory volume in 1 second (% predicted) after adjustment for age, body mass index, smoking status and pack-years. CONCLUSION: Our findings suggest that in COPD patients, adiponectin might be associated with COPD pathogenesis. © 2010 The Union.
Persistent Identifierhttp://hdl.handle.net/10722/124970
ISSN
2014 Impact Factor: 2.315
2014 SCImago Journal Rankings: 1.229
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KHen_HK
dc.contributor.authorYeung, SCen_HK
dc.contributor.authorYao, TJen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorCheung, AHKen_HK
dc.contributor.authorChanYeung, MMWen_HK
dc.contributor.authorMak, JCWen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorYew, WWen_HK
dc.contributor.authorWong, PCen_HK
dc.contributor.authorChau, CHen_HK
dc.contributor.authorLiu, Ren_HK
dc.contributor.authorLam, CWen_HK
dc.contributor.authorSo, Len_HK
dc.contributor.authorYee, Wen_HK
dc.contributor.authorChan, KKen_HK
dc.contributor.authorChan, KSen_HK
dc.contributor.authorChan, JWMen_HK
dc.contributor.authorChu, CMen_HK
dc.contributor.authorHo, ASSen_HK
dc.contributor.authorSit, KMen_HK
dc.contributor.authorChoo, Ken_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorKo, FWSen_HK
dc.contributor.authorYu, WCen_HK
dc.contributor.authorWong, Men_HK
dc.date.accessioned2010-10-31T11:04:16Z-
dc.date.available2010-10-31T11:04:16Z-
dc.date.issued2010en_HK
dc.identifier.citationInternational Journal Of Tuberculosis And Lung Disease, 2010, v. 14 n. 9, p. 1193-1200en_HK
dc.identifier.issn1027-3719en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124970-
dc.description.abstractBACKGROUND: Adiponectin is an anti-inflammatory adipokine that may play a role in chronic obstructive pulmonary disease (COPD) pathogenesis. OBJECTIVE: To investigate the relationship between adiponectin, interleukin (IL) 6, IL-8 and C-reactive protein (CRP) and COPD by evaluating these biomarkers in ever-smokers with or without the disease. METHOD: Plasma levels of adiponectin, IL-6, IL-8 and CRP were measured using commercially available kits in COPD patients (n = 71), healthy ever-smokers (n = 62) and non-smokers (n = 51). RESULTS: There were significant increases in plasma adiponectin, IL-6 and CRP in COPD patients (median [IQR] 4.39 μg/ml [2.68-6.98], 4.19 pg/ml [<2.40-6.40], 8.75 mg/l [4.26-40.63], respectively) compared to healthy ever-smokers (1.90 μg/ml [0.86-2.86], <2.40 pg/ml [<2.40-2.77], 3.71 mg/l [1.97-10.37 mg/l], respectively, P < 0.001) and non-smokers (1.76 μg/ml [1.34-2.52], <2.40 pg/ml [<2.40-2.78], 3.12 mg/l [2.11-5.71], respectively, P < 0.001). COPD patients had lower plasma IL-8 levels than healthy ever-smokers. Among ever-smokers with or without COPD, plasma adiponectin, IL-6 and CRP levels were inversely correlated with forced expiratory volume in 1 second (% predicted) after adjustment for age, body mass index, smoking status and pack-years. CONCLUSION: Our findings suggest that in COPD patients, adiponectin might be associated with COPD pathogenesis. © 2010 The Union.en_HK
dc.languageengen_HK
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.htmlen_HK
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Diseaseen_HK
dc.rightsInternational Journal Of Tuberculosis And Lung Disease. Copyright © International Union against Tuberculosis and Lung Disease.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAdiponectinen_HK
dc.subjectC-reactive proteinen_HK
dc.subjectChronic obstructive pulmonary diseaseen_HK
dc.subjectInterleukin-6en_HK
dc.subjectInterleukin-8en_HK
dc.subjectLung functionen_HK
dc.subject.meshAdiponectin - blood-
dc.subject.meshBiological Markers - blood-
dc.subject.meshC-Reactive Protein - metabolism-
dc.subject.meshPulmonary Disease, Chronic Obstructive - blood - physiopathology-
dc.subject.meshSmoking - blood-
dc.titleElevated plasma adiponectin levels in patients with chronic obstructive pulmonary diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1027-3719&volume=14&issue=9&spage=1193&epage=1200&date=2010&atitle=Elevated+plasma+adiponectin+levels+in+patients+with+chronic+obstructive+pulmonary+diseaseen_HK
dc.identifier.emailYao, TJ: tjyao@hkucc.hku.hken_HK
dc.identifier.emailIp, MSM: msmip@hku.hken_HK
dc.identifier.emailMak, JCW: judymak@hku.hken_HK
dc.identifier.authorityYao, TJ=rp00284en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.identifier.authorityMak, JCW=rp00352en_HK
dc.description.naturepostprint-
dc.identifier.pmid20819268en_HK
dc.identifier.scopuseid_2-s2.0-77956594638en_HK
dc.identifier.hkuros171596en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956594638&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1193en_HK
dc.identifier.epage1200en_HK
dc.identifier.isiWOS:000281275900021-
dc.publisher.placeFranceen_HK
dc.identifier.scopusauthoridChan, KH=26650626000en_HK
dc.identifier.scopusauthoridYeung, SC=25923636600en_HK
dc.identifier.scopusauthoridYao, TJ=7401886444en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridCheung, AHK=12795914100en_HK
dc.identifier.scopusauthoridChanYeung, MMW=54790582200en_HK
dc.identifier.scopusauthoridMak, JCW=7103323094en_HK
dc.identifier.scopusauthoridLam, WK=35934675100en_HK
dc.identifier.scopusauthoridYew, WW=7005934631en_HK
dc.identifier.scopusauthoridWong, PC=7403979916en_HK
dc.identifier.scopusauthoridChau, CH=7102320975en_HK
dc.identifier.scopusauthoridLiu, R=36087869100en_HK
dc.identifier.scopusauthoridLam, CW=7402527629en_HK
dc.identifier.scopusauthoridSo, L=35985409300en_HK
dc.identifier.scopusauthoridYee, W=7005216073en_HK
dc.identifier.scopusauthoridChan, KK=35073540100en_HK
dc.identifier.scopusauthoridChan, KS=7406031627en_HK
dc.identifier.scopusauthoridChan, JWM=34967874700en_HK
dc.identifier.scopusauthoridChu, CM=7404345558en_HK
dc.identifier.scopusauthoridHo, ASS=7402675199en_HK
dc.identifier.scopusauthoridSit, KM=37027147600en_HK
dc.identifier.scopusauthoridChoo, K=23391819100en_HK
dc.identifier.scopusauthoridLam, WK=37026410900en_HK
dc.identifier.scopusauthoridKo, FWS=7103224911en_HK
dc.identifier.scopusauthoridYu, WC=7403914214en_HK
dc.identifier.scopusauthoridWong, M=9278575000en_HK

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