Article: Elevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease

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TitleElevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease
AuthorsChan, KH4
Yeung, SC4
Yao, TJ2
Ip, MSM4
Cheung, AHK4
ChanYeung, MMW4
Mak, JCW2 4
Lam, WK11
Yew, WW14
Wong, PC14
Chau, CH14
Liu, R16
Lam, CW16
So, L8
Yee, W1
Chan, KK12
Chan, KS12
Chan, JWM6
Chu, CM9
Ho, ASS13
Sit, KM3
Choo, K10
Lam, WK10
Ko, FWS7
Yu, WC5
Wong, M15
KeywordsAdiponectin
C-reactive protein
Chronic obstructive pulmonary disease
Interleukin-6
Interleukin-8
Lung function
Issue Date2010
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
CitationInternational Journal Of Tuberculosis And Lung Disease, 2010, v. 14 n. 9, p. 1193-1200 [How to Cite?]
AbstractBACKGROUND: Adiponectin is an anti-inflammatory adipokine that may play a role in chronic obstructive pulmonary disease (COPD) pathogenesis. OBJECTIVE: To investigate the relationship between adiponectin, interleukin (IL) 6, IL-8 and C-reactive protein (CRP) and COPD by evaluating these biomarkers in ever-smokers with or without the disease. METHOD: Plasma levels of adiponectin, IL-6, IL-8 and CRP were measured using commercially available kits in COPD patients (n = 71), healthy ever-smokers (n = 62) and non-smokers (n = 51). RESULTS: There were significant increases in plasma adiponectin, IL-6 and CRP in COPD patients (median [IQR] 4.39 μg/ml [2.68-6.98], 4.19 pg/ml [<2.40-6.40], 8.75 mg/l [4.26-40.63], respectively) compared to healthy ever-smokers (1.90 μg/ml [0.86-2.86], <2.40 pg/ml [<2.40-2.77], 3.71 mg/l [1.97-10.37 mg/l], respectively, P < 0.001) and non-smokers (1.76 μg/ml [1.34-2.52], <2.40 pg/ml [<2.40-2.78], 3.12 mg/l [2.11-5.71], respectively, P < 0.001). COPD patients had lower plasma IL-8 levels than healthy ever-smokers. Among ever-smokers with or without COPD, plasma adiponectin, IL-6 and CRP levels were inversely correlated with forced expiratory volume in 1 second (% predicted) after adjustment for age, body mass index, smoking status and pack-years. CONCLUSION: Our findings suggest that in COPD patients, adiponectin might be associated with COPD pathogenesis. © 2010 The Union.
ISSN1027-3719
2011 Impact Factor: 2.731
2011 SCImago Journal Rankings: 0.249
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChan, KH
dc.contributor.authorYeung, SC
dc.contributor.authorYao, TJ
dc.contributor.authorIp, MSM
dc.contributor.authorCheung, AHK
dc.contributor.authorChanYeung, MMW
dc.contributor.authorMak, JCW
dc.contributor.authorLam, WK
dc.contributor.authorYew, WW
dc.contributor.authorWong, PC
dc.contributor.authorChau, CH
dc.contributor.authorLiu, R
dc.contributor.authorLam, CW
dc.contributor.authorSo, L
dc.contributor.authorYee, W
dc.contributor.authorChan, KK
dc.contributor.authorChan, KS
dc.contributor.authorChan, JWM
dc.contributor.authorChu, CM
dc.contributor.authorHo, ASS
dc.contributor.authorSit, KM
dc.contributor.authorChoo, K
dc.contributor.authorLam, WK
dc.contributor.authorKo, FWS
dc.contributor.authorYu, WC
dc.contributor.authorWong, M
dc.date.accessioned2010-10-31T11:04:16Z
dc.date.available2010-10-31T11:04:16Z
dc.date.issued2010
dc.description.abstractBACKGROUND: Adiponectin is an anti-inflammatory adipokine that may play a role in chronic obstructive pulmonary disease (COPD) pathogenesis. OBJECTIVE: To investigate the relationship between adiponectin, interleukin (IL) 6, IL-8 and C-reactive protein (CRP) and COPD by evaluating these biomarkers in ever-smokers with or without the disease. METHOD: Plasma levels of adiponectin, IL-6, IL-8 and CRP were measured using commercially available kits in COPD patients (n = 71), healthy ever-smokers (n = 62) and non-smokers (n = 51). RESULTS: There were significant increases in plasma adiponectin, IL-6 and CRP in COPD patients (median [IQR] 4.39 μg/ml [2.68-6.98], 4.19 pg/ml [<2.40-6.40], 8.75 mg/l [4.26-40.63], respectively) compared to healthy ever-smokers (1.90 μg/ml [0.86-2.86], <2.40 pg/ml [<2.40-2.77], 3.71 mg/l [1.97-10.37 mg/l], respectively, P < 0.001) and non-smokers (1.76 μg/ml [1.34-2.52], <2.40 pg/ml [<2.40-2.78], 3.12 mg/l [2.11-5.71], respectively, P < 0.001). COPD patients had lower plasma IL-8 levels than healthy ever-smokers. Among ever-smokers with or without COPD, plasma adiponectin, IL-6 and CRP levels were inversely correlated with forced expiratory volume in 1 second (% predicted) after adjustment for age, body mass index, smoking status and pack-years. CONCLUSION: Our findings suggest that in COPD patients, adiponectin might be associated with COPD pathogenesis. © 2010 The Union.
dc.description.naturepostprint
dc.identifier.citationInternational Journal Of Tuberculosis And Lung Disease, 2010, v. 14 n. 9, p. 1193-1200 [How to Cite?]
dc.identifier.epage1200
dc.identifier.hkuros171596
dc.identifier.isiWOS:000281275900021
dc.identifier.issn1027-3719
2011 Impact Factor: 2.731
2011 SCImago Journal Rankings: 0.249
dc.identifier.issue9
dc.identifier.openurl
dc.identifier.pmid20819268
dc.identifier.scopuseid_2-s2.0-77956594638
dc.identifier.spage1193
dc.identifier.urihttp://hdl.handle.net/10722/124970
dc.identifier.volume14
dc.languageeng
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
dc.publisher.placeFrance
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Disease
dc.relation.referencesReferences in Scopus
dc.rightsInternational Journal Of Tuberculosis And Lung Disease. Copyright © International Union against Tuberculosis and Lung Disease.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshAdiponectin - blood
dc.subject.meshBiological Markers - blood
dc.subject.meshC-Reactive Protein - metabolism
dc.subject.meshPulmonary Disease, Chronic Obstructive - blood - physiopathology
dc.subject.meshSmoking - blood
dc.subjectAdiponectin
dc.subjectC-reactive protein
dc.subjectChronic obstructive pulmonary disease
dc.subjectInterleukin-6
dc.subjectInterleukin-8
dc.subjectLung function
dc.titleElevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease
dc.typeArticle
Author Affiliations
  1. Kwong Wah Hospital
  2. The University of Hong Kong Li Ka Shing Faculty of Medicine
  3. Tuen Mun Hospital
  4. The University of Hong Kong
  5. Princess Margaret Hospital Hong Kong
  6. Queen Elizabeth Hospital Hong Kong
  7. Prince of Wales Hospital Hong Kong
  8. Pamela Youde Nethersole Eastern Hospital
  9. United Christian Hospital Hong Kong
  10. North District Hospital Hong Kong
  11. Queen Mary Hospital Hong Kong
  12. Haven of Hope Hospital
  13. Alice Ho Miu Ling Nethersole Hospital
  14. Grantham Hospital Hong Kong
  15. Caritas Medical Centre Hong Kong
  16. Ruttonjie Hospital