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Article: Elevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease
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TitleElevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease
 
AuthorsChan, KH3
Yeung, SC3
Yao, TJ2
Ip, MSM3
Cheung, AHK3
ChanYeung, MMW3
Mak, JCW2 3
Lam, WK11
Yew, WW13
Wong, PC13
Chau, CH13
Liu, R16
Lam, CW16
So, L8
Yee, W1
Chan, KK12
Chan, KS12
Chan, JWM6
Chu, CM9
Ho, ASS14
Sit, KM5
Choo, K10
Lam, WK10
Ko, FWS7
Yu, WC4
Wong, M15
 
KeywordsAdiponectin
C-reactive protein
Chronic obstructive pulmonary disease
Interleukin-6
Interleukin-8
Lung function
 
Issue Date2010
 
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
 
CitationInternational Journal Of Tuberculosis And Lung Disease, 2010, v. 14 n. 9, p. 1193-1200 [How to Cite?]
 
AbstractBACKGROUND: Adiponectin is an anti-inflammatory adipokine that may play a role in chronic obstructive pulmonary disease (COPD) pathogenesis. OBJECTIVE: To investigate the relationship between adiponectin, interleukin (IL) 6, IL-8 and C-reactive protein (CRP) and COPD by evaluating these biomarkers in ever-smokers with or without the disease. METHOD: Plasma levels of adiponectin, IL-6, IL-8 and CRP were measured using commercially available kits in COPD patients (n = 71), healthy ever-smokers (n = 62) and non-smokers (n = 51). RESULTS: There were significant increases in plasma adiponectin, IL-6 and CRP in COPD patients (median [IQR] 4.39 μg/ml [2.68-6.98], 4.19 pg/ml [<2.40-6.40], 8.75 mg/l [4.26-40.63], respectively) compared to healthy ever-smokers (1.90 μg/ml [0.86-2.86], <2.40 pg/ml [<2.40-2.77], 3.71 mg/l [1.97-10.37 mg/l], respectively, P < 0.001) and non-smokers (1.76 μg/ml [1.34-2.52], <2.40 pg/ml [<2.40-2.78], 3.12 mg/l [2.11-5.71], respectively, P < 0.001). COPD patients had lower plasma IL-8 levels than healthy ever-smokers. Among ever-smokers with or without COPD, plasma adiponectin, IL-6 and CRP levels were inversely correlated with forced expiratory volume in 1 second (% predicted) after adjustment for age, body mass index, smoking status and pack-years. CONCLUSION: Our findings suggest that in COPD patients, adiponectin might be associated with COPD pathogenesis. © 2010 The Union.
 
ISSN1027-3719
2013 Impact Factor: 2.756
2013 SCImago Journal Rankings: 1.527
 
ISI Accession Number IDWOS:000281275900021
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChan, KH
 
dc.contributor.authorYeung, SC
 
dc.contributor.authorYao, TJ
 
dc.contributor.authorIp, MSM
 
dc.contributor.authorCheung, AHK
 
dc.contributor.authorChanYeung, MMW
 
dc.contributor.authorMak, JCW
 
dc.contributor.authorLam, WK
 
dc.contributor.authorYew, WW
 
dc.contributor.authorWong, PC
 
dc.contributor.authorChau, CH
 
dc.contributor.authorLiu, R
 
dc.contributor.authorLam, CW
 
dc.contributor.authorSo, L
 
dc.contributor.authorYee, W
 
dc.contributor.authorChan, KK
 
dc.contributor.authorChan, KS
 
dc.contributor.authorChan, JWM
 
dc.contributor.authorChu, CM
 
dc.contributor.authorHo, ASS
 
dc.contributor.authorSit, KM
 
dc.contributor.authorChoo, K
 
dc.contributor.authorLam, WK
 
dc.contributor.authorKo, FWS
 
dc.contributor.authorYu, WC
 
dc.contributor.authorWong, M
 
dc.date.accessioned2010-10-31T11:04:16Z
 
dc.date.available2010-10-31T11:04:16Z
 
dc.date.issued2010
 
dc.description.abstractBACKGROUND: Adiponectin is an anti-inflammatory adipokine that may play a role in chronic obstructive pulmonary disease (COPD) pathogenesis. OBJECTIVE: To investigate the relationship between adiponectin, interleukin (IL) 6, IL-8 and C-reactive protein (CRP) and COPD by evaluating these biomarkers in ever-smokers with or without the disease. METHOD: Plasma levels of adiponectin, IL-6, IL-8 and CRP were measured using commercially available kits in COPD patients (n = 71), healthy ever-smokers (n = 62) and non-smokers (n = 51). RESULTS: There were significant increases in plasma adiponectin, IL-6 and CRP in COPD patients (median [IQR] 4.39 μg/ml [2.68-6.98], 4.19 pg/ml [<2.40-6.40], 8.75 mg/l [4.26-40.63], respectively) compared to healthy ever-smokers (1.90 μg/ml [0.86-2.86], <2.40 pg/ml [<2.40-2.77], 3.71 mg/l [1.97-10.37 mg/l], respectively, P < 0.001) and non-smokers (1.76 μg/ml [1.34-2.52], <2.40 pg/ml [<2.40-2.78], 3.12 mg/l [2.11-5.71], respectively, P < 0.001). COPD patients had lower plasma IL-8 levels than healthy ever-smokers. Among ever-smokers with or without COPD, plasma adiponectin, IL-6 and CRP levels were inversely correlated with forced expiratory volume in 1 second (% predicted) after adjustment for age, body mass index, smoking status and pack-years. CONCLUSION: Our findings suggest that in COPD patients, adiponectin might be associated with COPD pathogenesis. © 2010 The Union.
 
dc.description.naturepostprint
 
dc.identifier.citationInternational Journal Of Tuberculosis And Lung Disease, 2010, v. 14 n. 9, p. 1193-1200 [How to Cite?]
 
dc.identifier.epage1200
 
dc.identifier.hkuros171596
 
dc.identifier.isiWOS:000281275900021
 
dc.identifier.issn1027-3719
2013 Impact Factor: 2.756
2013 SCImago Journal Rankings: 1.527
 
dc.identifier.issue9
 
dc.identifier.openurl
 
dc.identifier.pmid20819268
 
dc.identifier.scopuseid_2-s2.0-77956594638
 
dc.identifier.spage1193
 
dc.identifier.urihttp://hdl.handle.net/10722/124970
 
dc.identifier.volume14
 
dc.languageeng
 
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
 
dc.publisher.placeFrance
 
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Disease
 
dc.relation.referencesReferences in Scopus
 
dc.rightsInternational Journal Of Tuberculosis And Lung Disease. Copyright © International Union against Tuberculosis and Lung Disease.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAdiponectin - blood
 
dc.subject.meshBiological Markers - blood
 
dc.subject.meshC-Reactive Protein - metabolism
 
dc.subject.meshPulmonary Disease, Chronic Obstructive - blood - physiopathology
 
dc.subject.meshSmoking - blood
 
dc.subjectAdiponectin
 
dc.subjectC-reactive protein
 
dc.subjectChronic obstructive pulmonary disease
 
dc.subjectInterleukin-6
 
dc.subjectInterleukin-8
 
dc.subjectLung function
 
dc.titleElevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease
 
dc.typeArticle
 
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<contributor.author>Yeung, SC</contributor.author>
<contributor.author>Yao, TJ</contributor.author>
<contributor.author>Ip, MSM</contributor.author>
<contributor.author>Cheung, AHK</contributor.author>
<contributor.author>ChanYeung, MMW</contributor.author>
<contributor.author>Mak, JCW</contributor.author>
<contributor.author>Lam, WK</contributor.author>
<contributor.author>Yew, WW</contributor.author>
<contributor.author>Wong, PC</contributor.author>
<contributor.author>Chau, CH</contributor.author>
<contributor.author>Liu, R</contributor.author>
<contributor.author>Lam, CW</contributor.author>
<contributor.author>So, L</contributor.author>
<contributor.author>Yee, W</contributor.author>
<contributor.author>Chan, KK</contributor.author>
<contributor.author>Chan, KS</contributor.author>
<contributor.author>Chan, JWM</contributor.author>
<contributor.author>Chu, CM</contributor.author>
<contributor.author>Ho, ASS</contributor.author>
<contributor.author>Sit, KM</contributor.author>
<contributor.author>Choo, K</contributor.author>
<contributor.author>Lam, WK</contributor.author>
<contributor.author>Ko, FWS</contributor.author>
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<description.abstract>BACKGROUND: Adiponectin is an anti-inflammatory adipokine that may play a role in chronic obstructive pulmonary disease (COPD) pathogenesis. OBJECTIVE: To investigate the relationship between adiponectin, interleukin (IL) 6, IL-8 and C-reactive protein (CRP) and COPD by evaluating these biomarkers in ever-smokers with or without the disease. METHOD: Plasma levels of adiponectin, IL-6, IL-8 and CRP were measured using commercially available kits in COPD patients (n = 71), healthy ever-smokers (n = 62) and non-smokers (n = 51). RESULTS: There were significant increases in plasma adiponectin, IL-6 and CRP in COPD patients (median [IQR] 4.39 &#956;g/ml [2.68-6.98], 4.19 pg/ml [&lt;2.40-6.40], 8.75 mg/l [4.26-40.63], respectively) compared to healthy ever-smokers (1.90 &#956;g/ml [0.86-2.86], &lt;2.40 pg/ml [&lt;2.40-2.77], 3.71 mg/l [1.97-10.37 mg/l], respectively, P &lt; 0.001) and non-smokers (1.76 &#956;g/ml [1.34-2.52], &lt;2.40 pg/ml [&lt;2.40-2.78], 3.12 mg/l [2.11-5.71], respectively, P &lt; 0.001). COPD patients had lower plasma IL-8 levels than healthy ever-smokers. Among ever-smokers with or without COPD, plasma adiponectin, IL-6 and CRP levels were inversely correlated with forced expiratory volume in 1 second (% predicted) after adjustment for age, body mass index, smoking status and pack-years. CONCLUSION: Our findings suggest that in COPD patients, adiponectin might be associated with COPD pathogenesis. &#169; 2010 The Union.</description.abstract>
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<subject>Adiponectin</subject>
<subject>C-reactive protein</subject>
<subject>Chronic obstructive pulmonary disease</subject>
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Author Affiliations
  1. Kwong Wah Hospital
  2. The University of Hong Kong Li Ka Shing Faculty of Medicine
  3. The University of Hong Kong
  4. Princess Margaret Hospital Hong Kong
  5. Tuen Mun Hospital
  6. Queen Elizabeth Hospital Hong Kong
  7. Prince of Wales Hospital Hong Kong
  8. Pamela Youde Nethersole Eastern Hospital
  9. United Christian Hospital Hong Kong
  10. North District Hospital Hong Kong
  11. Queen Mary Hospital Hong Kong
  12. Haven of Hope Hospital
  13. Grantham Hospital Hong Kong
  14. Alice Ho Miu Ling Nethersole Hospital
  15. Caritas Medical Centre Hong Kong
  16. Ruttonjie Hospital