Article: Queen Mary Utilization Of Antihypertensive Drugs Study: Use of antihypertensive drug classes in the Hypertension Clinic 1996-2004

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TitleQueen Mary Utilization Of Antihypertensive Drugs Study: Use of antihypertensive drug classes in the Hypertension Clinic 1996-2004
AuthorsCheung, BMY1
Wong, YL1 2
Lau, CP1
Keywordsβ-blocker
Angiotensin-converting enzyme inhibitor
Calcium channel blocker
Drug utilization
Hypertension
Thiazide diuretic
Issue Date2005
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCP
CitationBritish Journal Of Clinical Pharmacology, 2005, v. 60 n. 1, p. 90-97 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2125.2005.02388.x
AbstractBackground: Utilization of antihypertensive drugs in the hypertension outpatient clinic is surveyed periodically in the Queen Mary Utilization of Antihypertensive Drugs Study (QUADS). Methods: Two hundred and fifty-one patients (123 men, 128 women) were interviewed in April to December 1996, 439 patients (232 men, 207 women) in January to December 99 and 228 patients (109 men, 119 women) in April to May 2004. Their case notes were reviewed. Results: The percentages of patients receiving no drug (lifestyle modification), one, two, three and over three drugs were 7%, 48%, 36%, 7%, 3%, respectively, in 1996; 14%, 34%, 36%, 13% and 1%, respectively, in 1999; and 3%, 30%, 40%, 22% and 6%, respectively, in 2004. The number of drugs correlated with age and overweight. In 1996, 51% patients received calcium channel blockers (CCB); 46% β-blockers (BB); 32% angiotensin-converting enzyme inhibitors (ACEI); 15% thiazide diuretics; 5% α-blockers; and 0% angiotensin receptor blockers (ARB). In 1999, the respective figures were 52% CCB, 49% BB, 24% ACEI, 22% thiazide diuretics, 4% α-blockers and 2% ARB. In 2004, the respective figures were 65% CCB, 64% BB, 33% ACEI, 24% thiazide diuretics, 4% α-blockers and 7% ARB. Fewer patients on BBs reported side-effects. Only 11% were on α statin and 9% on aspirin. Blood pressure on treatment was 147 ± 21/84 ± 11 mmHg in 1999 and 144 ± 21/82 ± 11 mmHg in 2004. Conclusions: Increasingly, multiple drugs were used for blood pressure control. Blood pressure control needs improvement, especially in diabetics. CCBs and BBs were consistently popular. Thiazide diuretics, ARBs, statins and aspirin were underused, despite favourable clinical trial evidence. © 2005 Blackwell Publishing Ltd.
ISSN0306-5251
2011 Impact Factor: 2.958
2011 SCImago Journal Rankings: 0.231
DOIhttp://dx.doi.org/10.1111/j.1365-2125.2005.02388.x
PubMed Central IDPMC1884897
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCheung, BMY
dc.contributor.authorWong, YL
dc.contributor.authorLau, CP
dc.date.accessioned2010-10-31T11:04:00Z
dc.date.available2010-10-31T11:04:00Z
dc.date.issued2005
dc.description.abstractBackground: Utilization of antihypertensive drugs in the hypertension outpatient clinic is surveyed periodically in the Queen Mary Utilization of Antihypertensive Drugs Study (QUADS). Methods: Two hundred and fifty-one patients (123 men, 128 women) were interviewed in April to December 1996, 439 patients (232 men, 207 women) in January to December 99 and 228 patients (109 men, 119 women) in April to May 2004. Their case notes were reviewed. Results: The percentages of patients receiving no drug (lifestyle modification), one, two, three and over three drugs were 7%, 48%, 36%, 7%, 3%, respectively, in 1996; 14%, 34%, 36%, 13% and 1%, respectively, in 1999; and 3%, 30%, 40%, 22% and 6%, respectively, in 2004. The number of drugs correlated with age and overweight. In 1996, 51% patients received calcium channel blockers (CCB); 46% β-blockers (BB); 32% angiotensin-converting enzyme inhibitors (ACEI); 15% thiazide diuretics; 5% α-blockers; and 0% angiotensin receptor blockers (ARB). In 1999, the respective figures were 52% CCB, 49% BB, 24% ACEI, 22% thiazide diuretics, 4% α-blockers and 2% ARB. In 2004, the respective figures were 65% CCB, 64% BB, 33% ACEI, 24% thiazide diuretics, 4% α-blockers and 7% ARB. Fewer patients on BBs reported side-effects. Only 11% were on α statin and 9% on aspirin. Blood pressure on treatment was 147 ± 21/84 ± 11 mmHg in 1999 and 144 ± 21/82 ± 11 mmHg in 2004. Conclusions: Increasingly, multiple drugs were used for blood pressure control. Blood pressure control needs improvement, especially in diabetics. CCBs and BBs were consistently popular. Thiazide diuretics, ARBs, statins and aspirin were underused, despite favourable clinical trial evidence. © 2005 Blackwell Publishing Ltd.
dc.description.naturelink_to_OA_fulltext
dc.identifier.citationBritish Journal Of Clinical Pharmacology, 2005, v. 60 n. 1, p. 90-97 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2125.2005.02388.x
dc.identifier.citeulike232200
dc.identifier.doihttp://dx.doi.org/10.1111/j.1365-2125.2005.02388.x
dc.identifier.epage97
dc.identifier.hkuros180186
dc.identifier.isiWOS:000229912600013
dc.identifier.issn0306-5251
2011 Impact Factor: 2.958
2011 SCImago Journal Rankings: 0.231
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmcidPMC1884897
dc.identifier.pmid15963099
dc.identifier.scopuseid_2-s2.0-21744449230
dc.identifier.spage90
dc.identifier.urihttp://hdl.handle.net/10722/124965
dc.identifier.volume60
dc.languageeng
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCP
dc.publisher.placeUnited Kingdom
dc.relation.ispartofBritish Journal of Clinical Pharmacology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntihypertensive Agents - adverse effects - therapeutic use
dc.subject.meshDrug Utilization Review
dc.subject.meshHypertension - drug therapy
dc.subjectβ-blocker
dc.subjectAngiotensin-converting enzyme inhibitor
dc.subjectCalcium channel blocker
dc.subjectDrug utilization
dc.subjectHypertension
dc.subjectThiazide diuretic
dc.titleQueen Mary Utilization Of Antihypertensive Drugs Study: Use of antihypertensive drug classes in the Hypertension Clinic 1996-2004
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. University of Sunderland