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Article: Queen Mary Utilization Of Antihypertensive Drugs Study: Use of antihypertensive drug classes in the Hypertension Clinic 1996-2004

TitleQueen Mary Utilization Of Antihypertensive Drugs Study: Use of antihypertensive drug classes in the Hypertension Clinic 1996-2004
Authors
Keywordsβ-blocker
Angiotensin-converting enzyme inhibitor
Calcium channel blocker
Drug utilization
Hypertension
Thiazide diuretic
Issue Date2005
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCP
Citation
British Journal Of Clinical Pharmacology, 2005, v. 60 n. 1, p. 90-97 How to Cite?
Abstract
Background: Utilization of antihypertensive drugs in the hypertension outpatient clinic is surveyed periodically in the Queen Mary Utilization of Antihypertensive Drugs Study (QUADS). Methods: Two hundred and fifty-one patients (123 men, 128 women) were interviewed in April to December 1996, 439 patients (232 men, 207 women) in January to December 99 and 228 patients (109 men, 119 women) in April to May 2004. Their case notes were reviewed. Results: The percentages of patients receiving no drug (lifestyle modification), one, two, three and over three drugs were 7%, 48%, 36%, 7%, 3%, respectively, in 1996; 14%, 34%, 36%, 13% and 1%, respectively, in 1999; and 3%, 30%, 40%, 22% and 6%, respectively, in 2004. The number of drugs correlated with age and overweight. In 1996, 51% patients received calcium channel blockers (CCB); 46% β-blockers (BB); 32% angiotensin-converting enzyme inhibitors (ACEI); 15% thiazide diuretics; 5% α-blockers; and 0% angiotensin receptor blockers (ARB). In 1999, the respective figures were 52% CCB, 49% BB, 24% ACEI, 22% thiazide diuretics, 4% α-blockers and 2% ARB. In 2004, the respective figures were 65% CCB, 64% BB, 33% ACEI, 24% thiazide diuretics, 4% α-blockers and 7% ARB. Fewer patients on BBs reported side-effects. Only 11% were on α statin and 9% on aspirin. Blood pressure on treatment was 147 ± 21/84 ± 11 mmHg in 1999 and 144 ± 21/82 ± 11 mmHg in 2004. Conclusions: Increasingly, multiple drugs were used for blood pressure control. Blood pressure control needs improvement, especially in diabetics. CCBs and BBs were consistently popular. Thiazide diuretics, ARBs, statins and aspirin were underused, despite favourable clinical trial evidence. © 2005 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/124965
ISSN
2013 Impact Factor: 3.688
PubMed Central ID
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. University of Sunderland
DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorWong, YLen_HK
dc.contributor.authorLau, CPen_HK
dc.date.accessioned2010-10-31T11:04:00Z-
dc.date.available2010-10-31T11:04:00Z-
dc.date.issued2005en_HK
dc.identifier.citationBritish Journal Of Clinical Pharmacology, 2005, v. 60 n. 1, p. 90-97en_HK
dc.identifier.issn0306-5251en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124965-
dc.description.abstractBackground: Utilization of antihypertensive drugs in the hypertension outpatient clinic is surveyed periodically in the Queen Mary Utilization of Antihypertensive Drugs Study (QUADS). Methods: Two hundred and fifty-one patients (123 men, 128 women) were interviewed in April to December 1996, 439 patients (232 men, 207 women) in January to December 99 and 228 patients (109 men, 119 women) in April to May 2004. Their case notes were reviewed. Results: The percentages of patients receiving no drug (lifestyle modification), one, two, three and over three drugs were 7%, 48%, 36%, 7%, 3%, respectively, in 1996; 14%, 34%, 36%, 13% and 1%, respectively, in 1999; and 3%, 30%, 40%, 22% and 6%, respectively, in 2004. The number of drugs correlated with age and overweight. In 1996, 51% patients received calcium channel blockers (CCB); 46% β-blockers (BB); 32% angiotensin-converting enzyme inhibitors (ACEI); 15% thiazide diuretics; 5% α-blockers; and 0% angiotensin receptor blockers (ARB). In 1999, the respective figures were 52% CCB, 49% BB, 24% ACEI, 22% thiazide diuretics, 4% α-blockers and 2% ARB. In 2004, the respective figures were 65% CCB, 64% BB, 33% ACEI, 24% thiazide diuretics, 4% α-blockers and 7% ARB. Fewer patients on BBs reported side-effects. Only 11% were on α statin and 9% on aspirin. Blood pressure on treatment was 147 ± 21/84 ± 11 mmHg in 1999 and 144 ± 21/82 ± 11 mmHg in 2004. Conclusions: Increasingly, multiple drugs were used for blood pressure control. Blood pressure control needs improvement, especially in diabetics. CCBs and BBs were consistently popular. Thiazide diuretics, ARBs, statins and aspirin were underused, despite favourable clinical trial evidence. © 2005 Blackwell Publishing Ltd.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCPen_HK
dc.relation.ispartofBritish Journal of Clinical Pharmacologyen_HK
dc.subjectβ-blockeren_HK
dc.subjectAngiotensin-converting enzyme inhibitoren_HK
dc.subjectCalcium channel blockeren_HK
dc.subjectDrug utilizationen_HK
dc.subjectHypertensionen_HK
dc.subjectThiazide diureticen_HK
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntihypertensive Agents - adverse effects - therapeutic use-
dc.subject.meshDrug Utilization Review-
dc.subject.meshHypertension - drug therapy-
dc.titleQueen Mary Utilization Of Antihypertensive Drugs Study: Use of antihypertensive drug classes in the Hypertension Clinic 1996-2004en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0306-5251&volume=60&issue=1&spage=90&epage=97&date=2005&atitle=Queen+Mary+utilisation+of+antihypertensive+drugs+study:+use+of+antihypertensive+drug+classes+in+the+hypertension+clinic+1996-2004-
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1365-2125.2005.02388.xen_HK
dc.identifier.pmid15963099en_HK
dc.identifier.pmcidPMC1884897-
dc.identifier.scopuseid_2-s2.0-21744449230en_HK
dc.identifier.hkuros180186en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21744449230&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume60en_HK
dc.identifier.issue1en_HK
dc.identifier.spage90en_HK
dc.identifier.epage97en_HK
dc.identifier.isiWOS:000229912600013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridWong, YL=7403040297en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.citeulike232200-

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