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Article: The role of urotensin II in the metabolic syndrome

TitleThe role of urotensin II in the metabolic syndrome
Authors
KeywordsDiabetes
Hypertension
Inflammation
Metabolic syndrome
Urotensin II
Vasoactive peptide
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides
Citation
Peptides, 2008, v. 29 n. 5, p. 859-867 How to Cite?
Abstract
Urotensin II is a potent vasoconstrictive peptide that mediates both endothelium-independent vasoconstriction and endothelium-dependent vasodilatation. Its plasma level correlates positively with body weight and is raised in diabetes, renal failure, hypertension, and other cardiovascular diseases including congestive heart failure and carotid atherosclerosis. It can inhibit glucose-induced insulin secretion, and genetic variants in urotensin II gene are associated with insulin resistance and type 2 diabetes. Urotensin II also affects lipid metabolism in fish and food intake in mice. Recent studies have also demonstrated a role of urotensin II in inflammation and endothelial dysfunction. These findings suggest a close relationship between urotensin II and at least some components of the metabolic syndrome, including hypertension, insulin resistance, hyperglycemia, and inflammation. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/124955
ISSN
2013 Impact Factor: 2.614
2013 SCImago Journal Rankings: 0.971
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorOng, KLen_HK
dc.contributor.authorWong, LYFen_HK
dc.contributor.authorCheung, BMYen_HK
dc.date.accessioned2010-10-31T11:03:27Z-
dc.date.available2010-10-31T11:03:27Z-
dc.date.issued2008en_HK
dc.identifier.citationPeptides, 2008, v. 29 n. 5, p. 859-867en_HK
dc.identifier.issn0196-9781en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124955-
dc.description.abstractUrotensin II is a potent vasoconstrictive peptide that mediates both endothelium-independent vasoconstriction and endothelium-dependent vasodilatation. Its plasma level correlates positively with body weight and is raised in diabetes, renal failure, hypertension, and other cardiovascular diseases including congestive heart failure and carotid atherosclerosis. It can inhibit glucose-induced insulin secretion, and genetic variants in urotensin II gene are associated with insulin resistance and type 2 diabetes. Urotensin II also affects lipid metabolism in fish and food intake in mice. Recent studies have also demonstrated a role of urotensin II in inflammation and endothelial dysfunction. These findings suggest a close relationship between urotensin II and at least some components of the metabolic syndrome, including hypertension, insulin resistance, hyperglycemia, and inflammation. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptidesen_HK
dc.relation.ispartofPeptidesen_HK
dc.subjectDiabetesen_HK
dc.subjectHypertensionen_HK
dc.subjectInflammationen_HK
dc.subjectMetabolic syndromeen_HK
dc.subjectUrotensin IIen_HK
dc.subjectVasoactive peptideen_HK
dc.subject.meshAnimals-
dc.subject.meshCardiovascular Diseases - metabolism-
dc.subject.meshHumans-
dc.subject.meshMetabolic Syndrome X - metabolism - physiopathology-
dc.subject.meshUrotensins - genetics - metabolism-
dc.titleThe role of urotensin II in the metabolic syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0196-9781&volume=29&issue=5&spage=859&epage=867&date=2008&atitle=The+role+of+urotensin+II+in+the+metabolic+syndrome-
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.peptides.2007.06.003en_HK
dc.identifier.pmid17610998en_HK
dc.identifier.scopuseid_2-s2.0-42149115655en_HK
dc.identifier.hkuros180156en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42149115655&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue5en_HK
dc.identifier.spage859en_HK
dc.identifier.epage867en_HK
dc.identifier.isiWOS:000256007400027-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridWong, LYF=24476809800en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK

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