Article: The role of urotensin II in the metabolic syndrome

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TitleThe role of urotensin II in the metabolic syndrome
AuthorsOng, KL1
Wong, LYF1
Cheung, BMY1
KeywordsDiabetes
Hypertension
Inflammation
Metabolic syndrome
Urotensin II
Vasoactive peptide
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides
CitationPeptides, 2008, v. 29 n. 5, p. 859-867 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.peptides.2007.06.003
AbstractUrotensin II is a potent vasoconstrictive peptide that mediates both endothelium-independent vasoconstriction and endothelium-dependent vasodilatation. Its plasma level correlates positively with body weight and is raised in diabetes, renal failure, hypertension, and other cardiovascular diseases including congestive heart failure and carotid atherosclerosis. It can inhibit glucose-induced insulin secretion, and genetic variants in urotensin II gene are associated with insulin resistance and type 2 diabetes. Urotensin II also affects lipid metabolism in fish and food intake in mice. Recent studies have also demonstrated a role of urotensin II in inflammation and endothelial dysfunction. These findings suggest a close relationship between urotensin II and at least some components of the metabolic syndrome, including hypertension, insulin resistance, hyperglycemia, and inflammation. © 2007 Elsevier Inc. All rights reserved.
ISSN0196-9781
2011 Impact Factor: 2.434
2011 SCImago Journal Rankings: 0.180
DOIhttp://dx.doi.org/10.1016/j.peptides.2007.06.003
ISI Accession Number IDWOS:000256007400027
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorOng, KL
dc.contributor.authorWong, LYF
dc.contributor.authorCheung, BMY
dc.date.accessioned2010-10-31T11:03:27Z
dc.date.available2010-10-31T11:03:27Z
dc.date.issued2008
dc.description.abstractUrotensin II is a potent vasoconstrictive peptide that mediates both endothelium-independent vasoconstriction and endothelium-dependent vasodilatation. Its plasma level correlates positively with body weight and is raised in diabetes, renal failure, hypertension, and other cardiovascular diseases including congestive heart failure and carotid atherosclerosis. It can inhibit glucose-induced insulin secretion, and genetic variants in urotensin II gene are associated with insulin resistance and type 2 diabetes. Urotensin II also affects lipid metabolism in fish and food intake in mice. Recent studies have also demonstrated a role of urotensin II in inflammation and endothelial dysfunction. These findings suggest a close relationship between urotensin II and at least some components of the metabolic syndrome, including hypertension, insulin resistance, hyperglycemia, and inflammation. © 2007 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationPeptides, 2008, v. 29 n. 5, p. 859-867 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.peptides.2007.06.003
dc.identifier.doihttp://dx.doi.org/10.1016/j.peptides.2007.06.003
dc.identifier.epage867
dc.identifier.hkuros180156
dc.identifier.isiWOS:000256007400027
dc.identifier.issn0196-9781
2011 Impact Factor: 2.434
2011 SCImago Journal Rankings: 0.180
dc.identifier.issue5
dc.identifier.openurl
dc.identifier.pmid17610998
dc.identifier.scopuseid_2-s2.0-42149115655
dc.identifier.spage859
dc.identifier.urihttp://hdl.handle.net/10722/124955
dc.identifier.volume29
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides
dc.publisher.placeUnited States
dc.relation.ispartofPeptides
dc.relation.referencesReferences in Scopus
dc.subject.meshAnimals
dc.subject.meshCardiovascular Diseases - metabolism
dc.subject.meshHumans
dc.subject.meshMetabolic Syndrome X - metabolism - physiopathology
dc.subject.meshUrotensins - genetics - metabolism
dc.subjectDiabetes
dc.subjectHypertension
dc.subjectInflammation
dc.subjectMetabolic syndrome
dc.subjectUrotensin II
dc.subjectVasoactive peptide
dc.titleThe role of urotensin II in the metabolic syndrome
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong