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- Publisher Website: 10.1016/j.peptides.2007.06.003
- Scopus: eid_2-s2.0-42149115655
- PMID: 17610998
- WOS: WOS:000256007400027
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Article: The role of urotensin II in the metabolic syndrome
Title | The role of urotensin II in the metabolic syndrome |
---|---|
Authors | |
Keywords | Diabetes Hypertension Inflammation Metabolic syndrome Urotensin II Vasoactive peptide |
Issue Date | 2008 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides |
Citation | Peptides, 2008, v. 29 n. 5, p. 859-867 How to Cite? |
Abstract | Urotensin II is a potent vasoconstrictive peptide that mediates both endothelium-independent vasoconstriction and endothelium-dependent vasodilatation. Its plasma level correlates positively with body weight and is raised in diabetes, renal failure, hypertension, and other cardiovascular diseases including congestive heart failure and carotid atherosclerosis. It can inhibit glucose-induced insulin secretion, and genetic variants in urotensin II gene are associated with insulin resistance and type 2 diabetes. Urotensin II also affects lipid metabolism in fish and food intake in mice. Recent studies have also demonstrated a role of urotensin II in inflammation and endothelial dysfunction. These findings suggest a close relationship between urotensin II and at least some components of the metabolic syndrome, including hypertension, insulin resistance, hyperglycemia, and inflammation. © 2007 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/124955 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.826 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ong, KL | en_HK |
dc.contributor.author | Wong, LYF | en_HK |
dc.contributor.author | Cheung, BMY | en_HK |
dc.date.accessioned | 2010-10-31T11:03:27Z | - |
dc.date.available | 2010-10-31T11:03:27Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | Peptides, 2008, v. 29 n. 5, p. 859-867 | en_HK |
dc.identifier.issn | 0196-9781 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/124955 | - |
dc.description.abstract | Urotensin II is a potent vasoconstrictive peptide that mediates both endothelium-independent vasoconstriction and endothelium-dependent vasodilatation. Its plasma level correlates positively with body weight and is raised in diabetes, renal failure, hypertension, and other cardiovascular diseases including congestive heart failure and carotid atherosclerosis. It can inhibit glucose-induced insulin secretion, and genetic variants in urotensin II gene are associated with insulin resistance and type 2 diabetes. Urotensin II also affects lipid metabolism in fish and food intake in mice. Recent studies have also demonstrated a role of urotensin II in inflammation and endothelial dysfunction. These findings suggest a close relationship between urotensin II and at least some components of the metabolic syndrome, including hypertension, insulin resistance, hyperglycemia, and inflammation. © 2007 Elsevier Inc. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides | en_HK |
dc.relation.ispartof | Peptides | en_HK |
dc.subject | Diabetes | en_HK |
dc.subject | Hypertension | en_HK |
dc.subject | Inflammation | en_HK |
dc.subject | Metabolic syndrome | en_HK |
dc.subject | Urotensin II | en_HK |
dc.subject | Vasoactive peptide | en_HK |
dc.subject.mesh | Animals | - |
dc.subject.mesh | Cardiovascular Diseases - metabolism | - |
dc.subject.mesh | Humans | - |
dc.subject.mesh | Metabolic Syndrome X - metabolism - physiopathology | - |
dc.subject.mesh | Urotensins - genetics - metabolism | - |
dc.title | The role of urotensin II in the metabolic syndrome | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0196-9781&volume=29&issue=5&spage=859&epage=867&date=2008&atitle=The+role+of+urotensin+II+in+the+metabolic+syndrome | - |
dc.identifier.email | Cheung, BMY:mycheung@hku.hk | en_HK |
dc.identifier.authority | Cheung, BMY=rp01321 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.peptides.2007.06.003 | en_HK |
dc.identifier.pmid | 17610998 | - |
dc.identifier.scopus | eid_2-s2.0-42149115655 | en_HK |
dc.identifier.hkuros | 180156 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-42149115655&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 29 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 859 | en_HK |
dc.identifier.epage | 867 | en_HK |
dc.identifier.isi | WOS:000256007400027 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Ong, KL=8340854000 | en_HK |
dc.identifier.scopusauthorid | Wong, LYF=24476809800 | en_HK |
dc.identifier.scopusauthorid | Cheung, BMY=7103294806 | en_HK |
dc.identifier.issnl | 0196-9781 | - |