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Article: Organ-specific hemosiderosis and functional correlation in Chinese patients with thalassemia intermedia and hemoglobin H disease

TitleOrgan-specific hemosiderosis and functional correlation in Chinese patients with thalassemia intermedia and hemoglobin H disease
Authors
Issue Date2009
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htm
Citation
Annals Of Hematology, 2009, v. 88 n. 10, p. 947-950 How to Cite?
AbstractWe performed MRI assessment in 37 adult Chinese patients with thalassemia intermedia and hemoglobin H disease. Despite abnormal ferritin and liver T2*, only 5% of patients had cardiac hemosiderosis. The two patients with reduced ejection fraction had normal cardiac T2*. Half of the cases showed pituitary and pancreatic iron loading. Subclinical endocrine abnormalities (HOMA, insulin growth factor) showed correlation with pancreatic, pituitary, and cardiac MRI values. Prospective data with serial functional and imaging monitoring is needed to verify the utility for chelation to improve cardiac and endocrine function in this group of patients. © Springer-Verlag 2009.
Persistent Identifierhttp://hdl.handle.net/10722/124954
ISSN
2015 Impact Factor: 3.022
2015 SCImago Journal Rankings: 1.117
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorLam, WWMen_HK
dc.contributor.authorChu, WWCen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorWong, WKen_HK
dc.contributor.authorLau, Jen_HK
dc.contributor.authorYeung, YMen_HK
dc.contributor.authorLiu, HSYen_HK
dc.contributor.authorLiang, Ren_HK
dc.date.accessioned2010-10-31T11:03:24Z-
dc.date.available2010-10-31T11:03:24Z-
dc.date.issued2009en_HK
dc.identifier.citationAnnals Of Hematology, 2009, v. 88 n. 10, p. 947-950en_HK
dc.identifier.issn0939-5555en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124954-
dc.description.abstractWe performed MRI assessment in 37 adult Chinese patients with thalassemia intermedia and hemoglobin H disease. Despite abnormal ferritin and liver T2*, only 5% of patients had cardiac hemosiderosis. The two patients with reduced ejection fraction had normal cardiac T2*. Half of the cases showed pituitary and pancreatic iron loading. Subclinical endocrine abnormalities (HOMA, insulin growth factor) showed correlation with pancreatic, pituitary, and cardiac MRI values. Prospective data with serial functional and imaging monitoring is needed to verify the utility for chelation to improve cardiac and endocrine function in this group of patients. © Springer-Verlag 2009.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htmen_HK
dc.relation.ispartofAnnals of Hematologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshChilden_HK
dc.subject.meshChinaen_HK
dc.subject.meshEndocrine System - physiopathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHeart - physiologyen_HK
dc.subject.meshHemosiderosis - etiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver - pathologyen_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOrgan Specificityen_HK
dc.subject.meshPancreas - pathologyen_HK
dc.subject.meshPituitary Gland - pathologyen_HK
dc.subject.meshYoung Adulten_HK
dc.subject.meshalpha-Thalassemia - complicationsen_HK
dc.subject.meshbeta-Thalassemia - complicationsen_HK
dc.titleOrgan-specific hemosiderosis and functional correlation in Chinese patients with thalassemia intermedia and hemoglobin H diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0939-5555&volume=88&issue=10&spage=947&epage=950&date=2009&atitle=Organ-specific+hemosiderosis+and+functional+correlation+in+Chinese+patients+with+thalassemia+intermedia+and+hemoglobin+H+diseaseen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00277-009-0701-2en_HK
dc.identifier.pmid19165482-
dc.identifier.scopuseid_2-s2.0-69249157345en_HK
dc.identifier.hkuros180721en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69249157345&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume88en_HK
dc.identifier.issue10en_HK
dc.identifier.spage947en_HK
dc.identifier.epage950en_HK
dc.identifier.isiWOS:000269109900004-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridLam, WWM=13410486800en_HK
dc.identifier.scopusauthoridChu, WWC=26532214400en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridWong, WK=8835876000en_HK
dc.identifier.scopusauthoridLau, J=36903981300en_HK
dc.identifier.scopusauthoridYeung, YM=9941021000en_HK
dc.identifier.scopusauthoridLiu, HSY=26024250200en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.citeulike3940585-

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