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Article: Current understanding of the role of PPAR γ in gastrointestinal cancers

TitleCurrent understanding of the role of PPAR γ in gastrointestinal cancers
Authors
KeywordsAbdominal pain
Amino terminal sequence
Angiogenesis
Antiinflammatory activity
Antineoplastic activity
Issue Date2009
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/GetJournal.aspx?journal=PPAR
Citation
Ppar Research, 2009 How to Cite?
AbstractNumerous studies have indicated that PPAR plays multiple roles such as in inflammation, cell cycle control, cell proliferation, apoptosis, and carcinogenesis, thus PPAR contributes to the homeostasis. Many in vitro studies have showed that ligand-induced activation of PPAR possess antitumor effect in many cancers including CRC. However, the role of PPAR in gastrointestinal cancers, especially in colorectal cancer, is rather controversial. Nevertheless, some recent studies with the positive results on the possible application of PPAR ligands, such as Bezafibrate or Rosiglitazone in gastrointestinal cancers, have suggested a potential usefulness of PPAR agonists in cancer prevention and therapy. In this review, the authors discuss the recent developments in the role of PPAR in gastrointestinal cancers. Copyright © 2009 Bing Zou et al.
Persistent Identifierhttp://hdl.handle.net/10722/124952
ISSN
2015 Impact Factor: 2.935
2015 SCImago Journal Rankings: 0.946
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong10208191.49710.20600.301.01
Funding Information:

The studies reported in this review article were partially supported by the University of Hong Kong Seed Funding programs (Grant code: 10208191.49710.20600.301.01).

References

 

DC FieldValueLanguage
dc.contributor.authorQiao, Len_HK
dc.contributor.authorZou, Ben_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-10-31T11:03:17Z-
dc.date.available2010-10-31T11:03:17Z-
dc.date.issued2009en_HK
dc.identifier.citationPpar Research, 2009en_HK
dc.identifier.issn1687-4757en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124952-
dc.description.abstractNumerous studies have indicated that PPAR plays multiple roles such as in inflammation, cell cycle control, cell proliferation, apoptosis, and carcinogenesis, thus PPAR contributes to the homeostasis. Many in vitro studies have showed that ligand-induced activation of PPAR possess antitumor effect in many cancers including CRC. However, the role of PPAR in gastrointestinal cancers, especially in colorectal cancer, is rather controversial. Nevertheless, some recent studies with the positive results on the possible application of PPAR ligands, such as Bezafibrate or Rosiglitazone in gastrointestinal cancers, have suggested a potential usefulness of PPAR agonists in cancer prevention and therapy. In this review, the authors discuss the recent developments in the role of PPAR in gastrointestinal cancers. Copyright © 2009 Bing Zou et al.en_HK
dc.languageengen_HK
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/GetJournal.aspx?journal=PPARen_HK
dc.relation.ispartofPPAR Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAbdominal pain-
dc.subjectAmino terminal sequence-
dc.subjectAngiogenesis-
dc.subjectAntiinflammatory activity-
dc.subjectAntineoplastic activity-
dc.titleCurrent understanding of the role of PPAR γ in gastrointestinal cancersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1687-4757&volume=2009&issue=article no. 816957&spage=&epage=&date=2009&atitle=Current+understanding+of+the+role+of+PPARγ+in+gastrointestinal+cancers-
dc.identifier.emailQiao, L: lq8688@hotmail.comen_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityQiao, L=rp00513en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1155/2009/816957en_HK
dc.identifier.pmid19884989-
dc.identifier.pmcidPMC2770108-
dc.identifier.scopuseid_2-s2.0-72449162567en_HK
dc.identifier.hkuros173787en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-72449162567&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2009en_HK
dc.identifier.issuearticle no. 816957-
dc.identifier.isiWOS:000283417100001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridQiao, L=7202151719en_HK
dc.identifier.scopusauthoridZou, B=35228257300en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK

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