File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Common misdiagnoses in lymphomas and avoidance strategies

TitleCommon misdiagnoses in lymphomas and avoidance strategies
Authors
Issue Date2010
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/j.lancetoncol
Citation
The Lancet Oncology, 2010, v. 11 n. 6, p. 579-588 How to Cite?
AbstractLymphoma diagnosis integrates clinical, morphological, immunophenotypical, and molecular genetic features, as shown in WHO classifications of lymphoid malignancies. Diagnosis of lymphoma is challenging. Reactive lesions such as Kikuchi lymphadenitis, infectious mononucleosis, autoimmune lymphoproliferative syndrome, and immunoglobulin G4-related sclerosing disease can be misdiagnosed as lymphomas. Anaplastic large-cell lymphoma variants that are positive for anaplastic lymphoma kinase, classical Hodgkin's lymphoma variants, and infarcted lymphomas might be misdiagnosed as reactive disorders. Difficulties with classification of lymphomas are also encountered, such as the distinction of classical Hodgkin's lymphoma from anaplastic large-cell lymphoma that is negative for anaplastic lymphoma kinase. Interpretation of immunophenotyping results is complicated in some cases by aberrant or cross-lineage expression of lymphoid antigens on lymphomas, and the occasional lymphoid antigen expression on non-lymphoid malignancies. Molecular analysis can help to define clonality and lineage, but can be affected by the sensitivity and specificity of tests and cross-lineage gene rearrangement and pseudoclonality. To resolve these issues, a close collaboration between the clinician, histopathologist, and molecular biologist is needed. The aim of this review is to provide pathologists and clinicians with a concise account of these pitfalls and avoidance strategies. © 2010 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/124949
ISSN
2015 Impact Factor: 26.509
2015 SCImago Journal Rankings: 13.940
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, JKCen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-10-31T11:03:08Z-
dc.date.available2010-10-31T11:03:08Z-
dc.date.issued2010en_HK
dc.identifier.citationThe Lancet Oncology, 2010, v. 11 n. 6, p. 579-588en_HK
dc.identifier.issn1470-2045en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124949-
dc.description.abstractLymphoma diagnosis integrates clinical, morphological, immunophenotypical, and molecular genetic features, as shown in WHO classifications of lymphoid malignancies. Diagnosis of lymphoma is challenging. Reactive lesions such as Kikuchi lymphadenitis, infectious mononucleosis, autoimmune lymphoproliferative syndrome, and immunoglobulin G4-related sclerosing disease can be misdiagnosed as lymphomas. Anaplastic large-cell lymphoma variants that are positive for anaplastic lymphoma kinase, classical Hodgkin's lymphoma variants, and infarcted lymphomas might be misdiagnosed as reactive disorders. Difficulties with classification of lymphomas are also encountered, such as the distinction of classical Hodgkin's lymphoma from anaplastic large-cell lymphoma that is negative for anaplastic lymphoma kinase. Interpretation of immunophenotyping results is complicated in some cases by aberrant or cross-lineage expression of lymphoid antigens on lymphomas, and the occasional lymphoid antigen expression on non-lymphoid malignancies. Molecular analysis can help to define clonality and lineage, but can be affected by the sensitivity and specificity of tests and cross-lineage gene rearrangement and pseudoclonality. To resolve these issues, a close collaboration between the clinician, histopathologist, and molecular biologist is needed. The aim of this review is to provide pathologists and clinicians with a concise account of these pitfalls and avoidance strategies. © 2010 Elsevier Ltd.en_HK
dc.languageengen_HK
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/j.lancetoncolen_HK
dc.relation.ispartofThe Lancet Oncologyen_HK
dc.subject.meshAntigens, CD20 - analysisen_HK
dc.subject.meshAntigens, CD3 - analysisen_HK
dc.subject.meshDiagnostic Errorsen_HK
dc.subject.meshFalse Negative Reactionsen_HK
dc.subject.meshGene Rearrangementen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunophenotypingen_HK
dc.subject.meshLymphoma - classification - diagnosis - genetics - pathologyen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.titleCommon misdiagnoses in lymphomas and avoidance strategiesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1470-2045&volume=11&issue=6&spage=579&epage=588&date=2010&atitle=Common+misdiagnoses+in+lymphomas+and+avoidance+strategiesen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1470-2045(09)70351-1en_HK
dc.identifier.pmid20227918-
dc.identifier.scopuseid_2-s2.0-77953538242en_HK
dc.identifier.hkuros180763en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953538242&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue6en_HK
dc.identifier.spage579en_HK
dc.identifier.epage588en_HK
dc.identifier.isiWOS:000279019500030-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, JKC=7403287069en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.citeulike6868369-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats