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Article: Human embryonic stem cell-derived cardiomyocytes: Therapeutic potentials and limitations

TitleHuman embryonic stem cell-derived cardiomyocytes: Therapeutic potentials and limitations
Authors
KeywordsCardiomyocytes
Differentiation
Embryonic stem cells
Human
Pacemaker
Issue Date2006
PublisherNova Science Publishers, Inc. The Journal's web site is located at https://www.novapublishers.com/catalog/product_info.php?cPath=125&products_id=3730
Citation
Journal Of Stem Cells, 2006, v. 1 n. 2, p. 109-124 How to Cite?
AbstractEmbryonic stem cell (ESC) lines, derived from the inner cell mass (ICM) of blastocyst-stage embryos, are pluripotent and have a virtually unlimited capacity for self-renewal and differentiation into derivatives of all three germ layers. Human ESCs (hESCs), in particular, are the subject of intensive investigation for potential applications in developmental biology and medicine. A promising aspect of hESCs is their ability to differentiate into cardiomyocytes (CMs), which generally lack the capacity to regenerate, and therefore their potential for cell-replacement heart therapies. Molecular, cellular and physiological analyses demonstrate that hESC-derived CMs are functionally viable and that they exhibit characteristics typical of heart cells in the early stages of cardiac development. This article reviews the current state of hESC-CM research, their therapeutic potentials and limitations. © 2006 Nova Science Publishers, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/124946
ISSN
2015 SCImago Journal Rankings: 0.410
References

 

DC FieldValueLanguage
dc.contributor.authorLi, RAen_HK
dc.contributor.authorMoore, JCen_HK
dc.contributor.authorTarasova, YSen_HK
dc.contributor.authorBoheler, KRen_HK
dc.date.accessioned2010-10-31T11:02:58Z-
dc.date.available2010-10-31T11:02:58Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Stem Cells, 2006, v. 1 n. 2, p. 109-124en_HK
dc.identifier.issn1556-8539en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124946-
dc.description.abstractEmbryonic stem cell (ESC) lines, derived from the inner cell mass (ICM) of blastocyst-stage embryos, are pluripotent and have a virtually unlimited capacity for self-renewal and differentiation into derivatives of all three germ layers. Human ESCs (hESCs), in particular, are the subject of intensive investigation for potential applications in developmental biology and medicine. A promising aspect of hESCs is their ability to differentiate into cardiomyocytes (CMs), which generally lack the capacity to regenerate, and therefore their potential for cell-replacement heart therapies. Molecular, cellular and physiological analyses demonstrate that hESC-derived CMs are functionally viable and that they exhibit characteristics typical of heart cells in the early stages of cardiac development. This article reviews the current state of hESC-CM research, their therapeutic potentials and limitations. © 2006 Nova Science Publishers, Inc.en_HK
dc.languageengen_HK
dc.publisherNova Science Publishers, Inc. The Journal's web site is located at https://www.novapublishers.com/catalog/product_info.php?cPath=125&products_id=3730en_HK
dc.relation.ispartofJournal of Stem Cellsen_HK
dc.subjectCardiomyocytesen_HK
dc.subjectDifferentiationen_HK
dc.subjectEmbryonic stem cellsen_HK
dc.subjectHumanen_HK
dc.subjectPacemakeren_HK
dc.titleHuman embryonic stem cell-derived cardiomyocytes: Therapeutic potentials and limitationsen_HK
dc.typeArticleen_HK
dc.identifier.emailLi, RA:ronaldli@hkucc.hku.hken_HK
dc.identifier.authorityLi, RA=rp01352en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-34247098043en_HK
dc.identifier.hkuros183057en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247098043&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1en_HK
dc.identifier.issue2en_HK
dc.identifier.spage109en_HK
dc.identifier.epage124en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, RA=7404724466en_HK
dc.identifier.scopusauthoridMoore, JC=35185459800en_HK
dc.identifier.scopusauthoridTarasova, YS=8730977100en_HK
dc.identifier.scopusauthoridBoheler, KR=7005975654en_HK

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