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Article: Impact of JAK2V617F mutation on thrombosis and myeloid transformation in essential thrombocythemia: A multivariate analysis by Cox regression in 141 patients

TitleImpact of JAK2V617F mutation on thrombosis and myeloid transformation in essential thrombocythemia: A multivariate analysis by Cox regression in 141 patients
Authors
Keywordsessential thrombocythemia
JAK2
myeloid
thrombosis
transformation
Issue Date2010
PublisherManey Publishing. The Journal's web site is located at http://maney.co.uk/index.php/journals/hem/
Citation
Hematology, 2010, v. 15 n. 4, p. 187-192 How to Cite?
Abstract
Objective: To perform a multivariate analysis by Cox proportional hazard model of the impact of JAK2 V617F mutation on thrombosis and myeloid transformations in patients with essential thrombocythemia (ET). Patients and methods: The clinicopathologic features and outcome of a cohort of Chinese ET patients were retrospectively reviewed. JAK2 V617F mutation was detected by allele-specific polymerase chain reaction. Potential risk factors including JAK2 V617F that might impact on thrombosis and outcome were studied by multivariate analysis with Cox proportional hazard model. Results: Of 141 patients studied, JAK2 V617F was found in 80 cases (57%). JAK2 V617F was positively correlated with hemoglobin and leukocyte count at diagnosis. Univariate analysis showed significant thrombotic risks to be JAK2 V617F (P=0.006), hemoglobin >13 g/dl (P=0.015), and age >55 years (P=0.011). However, in multivariate analysis, only age and hemoglobin were independent risk factors. JAK2 V617F was unrelated to survival or leukemic/myelofibrotic transformation. Conclusion: In Chinese patients with ET, JAK2 V617F was positively associated with age, hemoglobin, and leukocyte count, but was not an independent risk for thrombosis. © 2010 W. S. Maney & Son Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/124931
ISSN
2013 Impact Factor: 1.189
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Princess Margaret Hospital Hong Kong
  3. Tuen Mun Hospital
  4. Queen Elizabeth Hospital Hong Kong
  5. Pamela Youde Nethersole Eastern Hospital
DC FieldValueLanguage
dc.contributor.authorChim, CSen_HK
dc.contributor.authorSim, JPen_HK
dc.contributor.authorChan, CCen_HK
dc.contributor.authorKho, BCen_HK
dc.contributor.authorChan, JCen_HK
dc.contributor.authorWong, LGen_HK
dc.contributor.authorLaw, Men_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-10-31T11:02:09Z-
dc.date.available2010-10-31T11:02:09Z-
dc.date.issued2010en_HK
dc.identifier.citationHematology, 2010, v. 15 n. 4, p. 187-192en_HK
dc.identifier.issn1024-5332en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124931-
dc.description.abstractObjective: To perform a multivariate analysis by Cox proportional hazard model of the impact of JAK2 V617F mutation on thrombosis and myeloid transformations in patients with essential thrombocythemia (ET). Patients and methods: The clinicopathologic features and outcome of a cohort of Chinese ET patients were retrospectively reviewed. JAK2 V617F mutation was detected by allele-specific polymerase chain reaction. Potential risk factors including JAK2 V617F that might impact on thrombosis and outcome were studied by multivariate analysis with Cox proportional hazard model. Results: Of 141 patients studied, JAK2 V617F was found in 80 cases (57%). JAK2 V617F was positively correlated with hemoglobin and leukocyte count at diagnosis. Univariate analysis showed significant thrombotic risks to be JAK2 V617F (P=0.006), hemoglobin >13 g/dl (P=0.015), and age >55 years (P=0.011). However, in multivariate analysis, only age and hemoglobin were independent risk factors. JAK2 V617F was unrelated to survival or leukemic/myelofibrotic transformation. Conclusion: In Chinese patients with ET, JAK2 V617F was positively associated with age, hemoglobin, and leukocyte count, but was not an independent risk for thrombosis. © 2010 W. S. Maney & Son Ltd.en_HK
dc.languageengen_HK
dc.publisherManey Publishing. The Journal's web site is located at http://maney.co.uk/index.php/journals/hem/en_HK
dc.relation.ispartofHematologyen_HK
dc.rightsHematology. Copyright © Maney Publishing.-
dc.subjectessential thrombocythemiaen_HK
dc.subjectJAK2en_HK
dc.subjectmyeloiden_HK
dc.subjectthrombosisen_HK
dc.subjecttransformationen_HK
dc.subject.meshJanus Kinase 2 - genetics-
dc.subject.meshLeukemia, Myeloid - etiology - genetics-
dc.subject.meshPoint Mutation-
dc.subject.meshThrombocythemia, Essential - complications - genetics - mortality - physiopathology-
dc.subject.meshThrombosis - etiology - genetics-
dc.titleImpact of JAK2V617F mutation on thrombosis and myeloid transformation in essential thrombocythemia: A multivariate analysis by Cox regression in 141 patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-5332&volume=15&issue=4&spage=187&epage=92&date=2010&atitle=Impact+of+JAK2V617F+mutation+on+thrombosis+and+myeloid+transformation+in+essential+thrombocythemia:+a+multivariate+analysis+by+Cox+regression+in+141+patients-
dc.identifier.emailChim, CS:jcschim@hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityChim, CS=rp00408en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1179/102453309X12583347113933en_HK
dc.identifier.pmid20670476en_HK
dc.identifier.scopuseid_2-s2.0-77955178851en_HK
dc.identifier.hkuros172846en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955178851&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue4en_HK
dc.identifier.spage187en_HK
dc.identifier.epage192en_HK
dc.identifier.isiWOS:000280648600001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChim, CS=7004597253en_HK
dc.identifier.scopusauthoridSim, JP=8501560000en_HK
dc.identifier.scopusauthoridChan, CC=7404814272en_HK
dc.identifier.scopusauthoridKho, BC=54880874500en_HK
dc.identifier.scopusauthoridChan, JC=9940606800en_HK
dc.identifier.scopusauthoridWong, LG=35793809000en_HK
dc.identifier.scopusauthoridLaw, M=9941188500en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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