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Article: Impact of JAK2V617F mutation on thrombosis and myeloid transformation in essential thrombocythemia: A multivariate analysis by Cox regression in 141 patients

TitleImpact of JAK2V617F mutation on thrombosis and myeloid transformation in essential thrombocythemia: A multivariate analysis by Cox regression in 141 patients
Authors
Keywordsessential thrombocythemia
JAK2
myeloid
thrombosis
transformation
Issue Date2010
PublisherManey Publishing. The Journal's web site is located at http://maney.co.uk/index.php/journals/hem/
Citation
Hematology, 2010, v. 15 n. 4, p. 187-192 How to Cite?
Abstract
Objective: To perform a multivariate analysis by Cox proportional hazard model of the impact of JAK2 V617F mutation on thrombosis and myeloid transformations in patients with essential thrombocythemia (ET). Patients and methods: The clinicopathologic features and outcome of a cohort of Chinese ET patients were retrospectively reviewed. JAK2 V617F mutation was detected by allele-specific polymerase chain reaction. Potential risk factors including JAK2 V617F that might impact on thrombosis and outcome were studied by multivariate analysis with Cox proportional hazard model. Results: Of 141 patients studied, JAK2 V617F was found in 80 cases (57%). JAK2 V617F was positively correlated with hemoglobin and leukocyte count at diagnosis. Univariate analysis showed significant thrombotic risks to be JAK2 V617F (P=0.006), hemoglobin >13 g/dl (P=0.015), and age >55 years (P=0.011). However, in multivariate analysis, only age and hemoglobin were independent risk factors. JAK2 V617F was unrelated to survival or leukemic/myelofibrotic transformation. Conclusion: In Chinese patients with ET, JAK2 V617F was positively associated with age, hemoglobin, and leukocyte count, but was not an independent risk for thrombosis. © 2010 W. S. Maney & Son Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/124931
ISSN
2013 Impact Factor: 1.189
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChim, CSen_HK
dc.contributor.authorSim, JPen_HK
dc.contributor.authorChan, CCen_HK
dc.contributor.authorKho, BCen_HK
dc.contributor.authorChan, JCen_HK
dc.contributor.authorWong, LGen_HK
dc.contributor.authorLaw, Men_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-10-31T11:02:09Z-
dc.date.available2010-10-31T11:02:09Z-
dc.date.issued2010en_HK
dc.identifier.citationHematology, 2010, v. 15 n. 4, p. 187-192en_HK
dc.identifier.issn1024-5332en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124931-
dc.description.abstractObjective: To perform a multivariate analysis by Cox proportional hazard model of the impact of JAK2 V617F mutation on thrombosis and myeloid transformations in patients with essential thrombocythemia (ET). Patients and methods: The clinicopathologic features and outcome of a cohort of Chinese ET patients were retrospectively reviewed. JAK2 V617F mutation was detected by allele-specific polymerase chain reaction. Potential risk factors including JAK2 V617F that might impact on thrombosis and outcome were studied by multivariate analysis with Cox proportional hazard model. Results: Of 141 patients studied, JAK2 V617F was found in 80 cases (57%). JAK2 V617F was positively correlated with hemoglobin and leukocyte count at diagnosis. Univariate analysis showed significant thrombotic risks to be JAK2 V617F (P=0.006), hemoglobin >13 g/dl (P=0.015), and age >55 years (P=0.011). However, in multivariate analysis, only age and hemoglobin were independent risk factors. JAK2 V617F was unrelated to survival or leukemic/myelofibrotic transformation. Conclusion: In Chinese patients with ET, JAK2 V617F was positively associated with age, hemoglobin, and leukocyte count, but was not an independent risk for thrombosis. © 2010 W. S. Maney & Son Ltd.en_HK
dc.languageengen_HK
dc.publisherManey Publishing. The Journal's web site is located at http://maney.co.uk/index.php/journals/hem/en_HK
dc.relation.ispartofHematologyen_HK
dc.rightsHematology. Copyright © Maney Publishing.-
dc.subjectessential thrombocythemiaen_HK
dc.subjectJAK2en_HK
dc.subjectmyeloiden_HK
dc.subjectthrombosisen_HK
dc.subjecttransformationen_HK
dc.subject.meshJanus Kinase 2 - genetics-
dc.subject.meshLeukemia, Myeloid - etiology - genetics-
dc.subject.meshPoint Mutation-
dc.subject.meshThrombocythemia, Essential - complications - genetics - mortality - physiopathology-
dc.subject.meshThrombosis - etiology - genetics-
dc.titleImpact of JAK2V617F mutation on thrombosis and myeloid transformation in essential thrombocythemia: A multivariate analysis by Cox regression in 141 patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-5332&volume=15&issue=4&spage=187&epage=92&date=2010&atitle=Impact+of+JAK2V617F+mutation+on+thrombosis+and+myeloid+transformation+in+essential+thrombocythemia:+a+multivariate+analysis+by+Cox+regression+in+141+patients-
dc.identifier.emailChim, CS:jcschim@hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityChim, CS=rp00408en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1179/102453309X12583347113933en_HK
dc.identifier.pmid20670476en_HK
dc.identifier.scopuseid_2-s2.0-77955178851en_HK
dc.identifier.hkuros172846en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955178851&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue4en_HK
dc.identifier.spage187en_HK
dc.identifier.epage192en_HK
dc.identifier.isiWOS:000280648600001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChim, CS=7004597253en_HK
dc.identifier.scopusauthoridSim, JP=8501560000en_HK
dc.identifier.scopusauthoridChan, CC=7404814272en_HK
dc.identifier.scopusauthoridKho, BC=54880874500en_HK
dc.identifier.scopusauthoridChan, JC=9940606800en_HK
dc.identifier.scopusauthoridWong, LG=35793809000en_HK
dc.identifier.scopusauthoridLaw, M=9941188500en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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