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Article: Are MADIT II criteria for implantable cardioverter defibrillator implantation appropriate for chinese patients?

TitleAre MADIT II criteria for implantable cardioverter defibrillator implantation appropriate for chinese patients?
Authors
KeywordsHeart failure
Implantable cardioverter-defibrillator
MADIT-II trial
Myocardial infarction
Sudden cardiac death
Issue Date2010
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873
Citation
Journal Of Cardiovascular Electrophysiology, 2010, v. 21 n. 3, p. 231-235 How to Cite?
AbstractMADIT II Criteria for Implantable Cardioverter. Background: MADIT-II demonstrated that prophylactic implantation of an implantable cardioverter-defibrillator (ICD) device prevents sudden cardiac death (SCD) in patients with myocardial infarction (MI) and impaired left ventricular ejection fraction (LVEF). It remains unclear whether the MADIT-II criteria for ICD implantation are appropriate for Chinese patients. Methods and Results: We compared the clinical characteristics and outcome for a cohort of consecutive Chinese patients who satisfied MADIT-II criteria for ICD implantation with the original published MADIT-II population. Seventy consecutive patients who satisfied MADIT-II criteria but did not undergo ICD implantation (age: 67 years, male: 77%) were studied. Their baseline demographics were comparable with the original MADIT-II cohort with the exception of a higher incidence of diabetes mellitus. After follow-up of 35 months, most deaths (78%) were due to cardiac causes (72% due to SCD). The 2-year SCD rate (10.0%) was comparable with that of the MADIT-II conventional group (12.1%), but higher than the MADIT-II defibrillator group (4.9%). Similarly, the 2-year non-SCD rate was 3.0%, also comparable with the MADIT-II conventional group (4.6%), but lower than the MADIT-II defibrillator group (7.0%). Cox regression analysis revealed that advance NYHA function class (Hazard Ratio [HR]: 3.5, 95% Confidence Interval [CI]: 1.48-8.24, P = 0.004) and the lack of statin therapy (HR: 3.7, 95%CI: 1.35-10.17, P = 0.011) were independent predictors for mortality in the MADIT-II eligible patients. Conclusion: Chinese patients who satisfy MADIT-II criteria for ICD implantation are at similar risk of SCD and non-SCD as the original MADIT-II subjects. Implantation of an ICD in Chinese patients is appropriate. © 2009 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/124907
ISSN
2015 Impact Factor: 3.097
2015 SCImago Journal Rankings: 1.863
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorPong, Ven_HK
dc.contributor.authorHo, HHen_HK
dc.contributor.authorLiu, Sen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorLi, SWen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-10-31T11:00:50Z-
dc.date.available2010-10-31T11:00:50Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Cardiovascular Electrophysiology, 2010, v. 21 n. 3, p. 231-235en_HK
dc.identifier.issn1045-3873en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124907-
dc.description.abstractMADIT II Criteria for Implantable Cardioverter. Background: MADIT-II demonstrated that prophylactic implantation of an implantable cardioverter-defibrillator (ICD) device prevents sudden cardiac death (SCD) in patients with myocardial infarction (MI) and impaired left ventricular ejection fraction (LVEF). It remains unclear whether the MADIT-II criteria for ICD implantation are appropriate for Chinese patients. Methods and Results: We compared the clinical characteristics and outcome for a cohort of consecutive Chinese patients who satisfied MADIT-II criteria for ICD implantation with the original published MADIT-II population. Seventy consecutive patients who satisfied MADIT-II criteria but did not undergo ICD implantation (age: 67 years, male: 77%) were studied. Their baseline demographics were comparable with the original MADIT-II cohort with the exception of a higher incidence of diabetes mellitus. After follow-up of 35 months, most deaths (78%) were due to cardiac causes (72% due to SCD). The 2-year SCD rate (10.0%) was comparable with that of the MADIT-II conventional group (12.1%), but higher than the MADIT-II defibrillator group (4.9%). Similarly, the 2-year non-SCD rate was 3.0%, also comparable with the MADIT-II conventional group (4.6%), but lower than the MADIT-II defibrillator group (7.0%). Cox regression analysis revealed that advance NYHA function class (Hazard Ratio [HR]: 3.5, 95% Confidence Interval [CI]: 1.48-8.24, P = 0.004) and the lack of statin therapy (HR: 3.7, 95%CI: 1.35-10.17, P = 0.011) were independent predictors for mortality in the MADIT-II eligible patients. Conclusion: Chinese patients who satisfy MADIT-II criteria for ICD implantation are at similar risk of SCD and non-SCD as the original MADIT-II subjects. Implantation of an ICD in Chinese patients is appropriate. © 2009 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873en_HK
dc.relation.ispartofJournal of Cardiovascular Electrophysiologyen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectHeart failureen_HK
dc.subjectImplantable cardioverter-defibrillatoren_HK
dc.subjectMADIT-II trialen_HK
dc.subjectMyocardial infarctionen_HK
dc.subjectSudden cardiac deathen_HK
dc.subject.meshAged-
dc.subject.meshChina - epidemiology-
dc.subject.meshDefibrillators, Implantable - statistics and numerical data-
dc.subject.meshMyocardial Infarction - mortality - prevention and control-
dc.subject.meshVentricular Dysfunction, Left - mortality - prevention and control-
dc.titleAre MADIT II criteria for implantable cardioverter defibrillator implantation appropriate for chinese patients?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1045-3873&volume=21&issue=3&spage=231&epage=235&date=2010&atitle=Are+MADIT+II+criteria+for+implantable+cardioverter+defibrillator+implantation+appropriate+for+Chinese+patients?-
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailLiu, S:shasha.vivi@gmail.comen_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityLiu, S=rp01628en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1540-8167.2009.01609.xen_HK
dc.identifier.pmid19804551-
dc.identifier.scopuseid_2-s2.0-77649172204en_HK
dc.identifier.hkuros161391-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77649172204&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue3en_HK
dc.identifier.spage231en_HK
dc.identifier.epage235en_HK
dc.identifier.isiWOS:000274812700003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridPong, V=26025247300en_HK
dc.identifier.scopusauthoridHo, HH=7401465369en_HK
dc.identifier.scopusauthoridLiu, S=16424616100en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridLi, SW=13807028100en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.citeulike6807153-

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