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Article: The burden and measurement of cardiovascular disease in SSc

TitleThe burden and measurement of cardiovascular disease in SSc
Authors
Issue Date2010
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nrrheum/index.html
Citation
Nature Reviews Rheumatology, 2010, v. 6 n. 7, p. 430-434 How to Cite?
AbstractThe prognosis for patients with systemic sclerosis (SSc) has improved in the past three decades, with fewer patients succumbing to renal-crisis-related death. While pulmonary fibrosis and hypertension are currently the most frequent causes of death, there is evidence that cardiovascular disease will have an important role in the long-term prognosis of SSc in the future. Ischemia-reperfusion injury and endothelial dysfunction are cardinal features of SSc, and may predispose a patient to microvascular disease and atherosclerosis. In order to alleviate the cardiovascular burden in patients with SSc, it is important to detect endothelial dysfunction, microvascular flow disturbance and atherosclerosis. Noninvasive techniques that evaluate flow-mediated dilatation and arterial pulse waves (endothelial function measurements), microvascular blood flow (measurement of the microcirculation), carotid intima-media thickness and left ventricular hypertrophy (detection of atherosclerosis) are recommended. In addition, these measurements will facilitate trials of therapeutic strategies that, in addition to controlling conventional risk factors, prevent and treat cardiovascular disease in patients with SSc. © 2010 Macmillan Publishers Limited. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/124904
ISSN
2015 Impact Factor: 10.531
2015 SCImago Journal Rankings: 2.728
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMok, MYen_HK
dc.contributor.authorLau, CSen_HK
dc.date.accessioned2010-10-31T11:00:40Z-
dc.date.available2010-10-31T11:00:40Z-
dc.date.issued2010en_HK
dc.identifier.citationNature Reviews Rheumatology, 2010, v. 6 n. 7, p. 430-434en_HK
dc.identifier.issn1759-4790en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124904-
dc.description.abstractThe prognosis for patients with systemic sclerosis (SSc) has improved in the past three decades, with fewer patients succumbing to renal-crisis-related death. While pulmonary fibrosis and hypertension are currently the most frequent causes of death, there is evidence that cardiovascular disease will have an important role in the long-term prognosis of SSc in the future. Ischemia-reperfusion injury and endothelial dysfunction are cardinal features of SSc, and may predispose a patient to microvascular disease and atherosclerosis. In order to alleviate the cardiovascular burden in patients with SSc, it is important to detect endothelial dysfunction, microvascular flow disturbance and atherosclerosis. Noninvasive techniques that evaluate flow-mediated dilatation and arterial pulse waves (endothelial function measurements), microvascular blood flow (measurement of the microcirculation), carotid intima-media thickness and left ventricular hypertrophy (detection of atherosclerosis) are recommended. In addition, these measurements will facilitate trials of therapeutic strategies that, in addition to controlling conventional risk factors, prevent and treat cardiovascular disease in patients with SSc. © 2010 Macmillan Publishers Limited. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nrrheum/index.htmlen_HK
dc.relation.ispartofNature Reviews Rheumatologyen_HK
dc.subject.meshCardiovascular Diseases - diagnosis - etiology-
dc.subject.meshHumans-
dc.subject.meshScleroderma, Systemic - complications - mortality-
dc.titleThe burden and measurement of cardiovascular disease in SScen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1759-4790&volume=6&issue=7&spage=430&epage=434&date=2010&atitle=The+burden+and+measurement+of+cardiovascular+disease+in+systemic+sclerosis-
dc.identifier.emailMok, MY:temy@hkucc.hku.hken_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nrrheum.2010.65en_HK
dc.identifier.pmid20517296-
dc.identifier.scopuseid_2-s2.0-77954314301en_HK
dc.identifier.hkuros174740en_HK
dc.identifier.hkuros195426-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954314301&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue7en_HK
dc.identifier.spage430en_HK
dc.identifier.epage434en_HK
dc.identifier.isiWOS:000279428500009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK

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