Article: Peripheral Doses from Noncoplanar IMRT for Pediatric Radiation Therapy

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TitlePeripheral Doses from Noncoplanar IMRT for Pediatric Radiation Therapy
AuthorsKan, MWK1
Leung, LHT1
Kwong, DLW1
Wong, W1
Lam, N1
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/meddos
CitationMedical Dosimetry, 2010, v. 35 n. 4, p. 255-263 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.meddos.2009.07.003
AbstractThe use of noncoplanar intensity-modulated radiation therapy (IMRT) might result in better sparing of some critical organs because of a higher degree of freedom in beam angle optimization. However, this can lead to a potential increase in peripheral dose compared with coplanar IMRT. The peripheral dose from noncoplanar IMRT has not been previously quantified. This study examines the peripheral dose from noncoplanar IMRT compared with coplanar IMRT for pediatric radiation therapy. Five cases with different pediatric malignancies in head and neck were planned with both coplanar and noncoplanar IMRT techniques. The plans were performed such that the tumor coverage, conformality, and dose uniformity were comparable for both techniques. To measure the peripheral doses of the 2 techniques, thermoluminescent dosimeters (TLD) were placed in 10 different organs of a 5-year-old pediatric anthropomorphic phantom. With the use of noncoplanar beams, the peripheral doses to the spinal cord, bone marrow, lung, and breast were found to be 1.8-2.5 times of those using the coplanar technique. This is mainly because of the additional internal scatter dose from the noncoplanar beams. Although the use of noncoplanar technique can result in better sparing of certain organs such as the optic nerves, lens, or inner ears depending on how the beam angles were optimized on each patient, oncologists should be alert of the possibility of significantly increasing the peripheral doses to certain radiation-sensitive organs such as bone marrow and breast. This might increase the secondary cancer risk to patients at young age. © 2010 American Association of Medical Dosimetrists.
ISSN0958-3947
2011 Impact Factor: 1.0
2011 SCImago Journal Rankings: 0.099
DOIhttp://dx.doi.org/10.1016/j.meddos.2009.07.003
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorKan, MWK
dc.contributor.authorLeung, LHT
dc.contributor.authorKwong, DLW
dc.contributor.authorWong, W
dc.contributor.authorLam, N
dc.date.accessioned2010-10-31T10:44:43Z
dc.date.available2010-10-31T10:44:43Z
dc.date.issued2010
dc.description.abstractThe use of noncoplanar intensity-modulated radiation therapy (IMRT) might result in better sparing of some critical organs because of a higher degree of freedom in beam angle optimization. However, this can lead to a potential increase in peripheral dose compared with coplanar IMRT. The peripheral dose from noncoplanar IMRT has not been previously quantified. This study examines the peripheral dose from noncoplanar IMRT compared with coplanar IMRT for pediatric radiation therapy. Five cases with different pediatric malignancies in head and neck were planned with both coplanar and noncoplanar IMRT techniques. The plans were performed such that the tumor coverage, conformality, and dose uniformity were comparable for both techniques. To measure the peripheral doses of the 2 techniques, thermoluminescent dosimeters (TLD) were placed in 10 different organs of a 5-year-old pediatric anthropomorphic phantom. With the use of noncoplanar beams, the peripheral doses to the spinal cord, bone marrow, lung, and breast were found to be 1.8-2.5 times of those using the coplanar technique. This is mainly because of the additional internal scatter dose from the noncoplanar beams. Although the use of noncoplanar technique can result in better sparing of certain organs such as the optic nerves, lens, or inner ears depending on how the beam angles were optimized on each patient, oncologists should be alert of the possibility of significantly increasing the peripheral doses to certain radiation-sensitive organs such as bone marrow and breast. This might increase the secondary cancer risk to patients at young age. © 2010 American Association of Medical Dosimetrists.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationMedical Dosimetry, 2010, v. 35 n. 4, p. 255-263 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.meddos.2009.07.003
dc.identifier.citeulike5828151
dc.identifier.doihttp://dx.doi.org/10.1016/j.meddos.2009.07.003
dc.identifier.epage263
dc.identifier.hkuros180266
dc.identifier.isiWOS:000284451800003
dc.identifier.issn0958-3947
2011 Impact Factor: 1.0
2011 SCImago Journal Rankings: 0.099
dc.identifier.issue4
dc.identifier.openurl
dc.identifier.pmid19962878
dc.identifier.scopuseid_2-s2.0-78049486766
dc.identifier.spage255
dc.identifier.urihttp://hdl.handle.net/10722/124621
dc.identifier.volume35
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/meddos
dc.publisher.placeUnited States
dc.relation.ispartofMedical Dosimetry
dc.relation.referencesReferences in Scopus
dc.subject.meshBody Burden
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshHead and Neck Neoplasms - radiotherapy
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshMale
dc.subject.meshRadiotherapy, Conformal - methods
dc.subject.meshWhole-Body Counting - methods
dc.titlePeripheral Doses from Noncoplanar IMRT for Pediatric Radiation Therapy
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong