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Article: Peripheral Doses from Noncoplanar IMRT for Pediatric Radiation Therapy
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TitlePeripheral Doses from Noncoplanar IMRT for Pediatric Radiation Therapy
 
AuthorsKan, MWK1
Leung, LHT1
Kwong, DLW1
Wong, W1
Lam, N1
 
Issue Date2010
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/meddos
 
CitationMedical Dosimetry, 2010, v. 35 n. 4, p. 255-263 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.meddos.2009.07.003
 
AbstractThe use of noncoplanar intensity-modulated radiation therapy (IMRT) might result in better sparing of some critical organs because of a higher degree of freedom in beam angle optimization. However, this can lead to a potential increase in peripheral dose compared with coplanar IMRT. The peripheral dose from noncoplanar IMRT has not been previously quantified. This study examines the peripheral dose from noncoplanar IMRT compared with coplanar IMRT for pediatric radiation therapy. Five cases with different pediatric malignancies in head and neck were planned with both coplanar and noncoplanar IMRT techniques. The plans were performed such that the tumor coverage, conformality, and dose uniformity were comparable for both techniques. To measure the peripheral doses of the 2 techniques, thermoluminescent dosimeters (TLD) were placed in 10 different organs of a 5-year-old pediatric anthropomorphic phantom. With the use of noncoplanar beams, the peripheral doses to the spinal cord, bone marrow, lung, and breast were found to be 1.8-2.5 times of those using the coplanar technique. This is mainly because of the additional internal scatter dose from the noncoplanar beams. Although the use of noncoplanar technique can result in better sparing of certain organs such as the optic nerves, lens, or inner ears depending on how the beam angles were optimized on each patient, oncologists should be alert of the possibility of significantly increasing the peripheral doses to certain radiation-sensitive organs such as bone marrow and breast. This might increase the secondary cancer risk to patients at young age. © 2010 American Association of Medical Dosimetrists.
 
ISSN0958-3947
2012 Impact Factor: 1.009
2012 SCImago Journal Rankings: 0.499
 
DOIhttp://dx.doi.org/10.1016/j.meddos.2009.07.003
 
ISI Accession Number IDWOS:000284451800003
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorKan, MWK
 
dc.contributor.authorLeung, LHT
 
dc.contributor.authorKwong, DLW
 
dc.contributor.authorWong, W
 
dc.contributor.authorLam, N
 
dc.date.accessioned2010-10-31T10:44:43Z
 
dc.date.available2010-10-31T10:44:43Z
 
dc.date.issued2010
 
dc.description.abstractThe use of noncoplanar intensity-modulated radiation therapy (IMRT) might result in better sparing of some critical organs because of a higher degree of freedom in beam angle optimization. However, this can lead to a potential increase in peripheral dose compared with coplanar IMRT. The peripheral dose from noncoplanar IMRT has not been previously quantified. This study examines the peripheral dose from noncoplanar IMRT compared with coplanar IMRT for pediatric radiation therapy. Five cases with different pediatric malignancies in head and neck were planned with both coplanar and noncoplanar IMRT techniques. The plans were performed such that the tumor coverage, conformality, and dose uniformity were comparable for both techniques. To measure the peripheral doses of the 2 techniques, thermoluminescent dosimeters (TLD) were placed in 10 different organs of a 5-year-old pediatric anthropomorphic phantom. With the use of noncoplanar beams, the peripheral doses to the spinal cord, bone marrow, lung, and breast were found to be 1.8-2.5 times of those using the coplanar technique. This is mainly because of the additional internal scatter dose from the noncoplanar beams. Although the use of noncoplanar technique can result in better sparing of certain organs such as the optic nerves, lens, or inner ears depending on how the beam angles were optimized on each patient, oncologists should be alert of the possibility of significantly increasing the peripheral doses to certain radiation-sensitive organs such as bone marrow and breast. This might increase the secondary cancer risk to patients at young age. © 2010 American Association of Medical Dosimetrists.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationMedical Dosimetry, 2010, v. 35 n. 4, p. 255-263 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.meddos.2009.07.003
 
dc.identifier.citeulike5828151
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.meddos.2009.07.003
 
dc.identifier.epage263
 
dc.identifier.hkuros180266
 
dc.identifier.isiWOS:000284451800003
 
dc.identifier.issn0958-3947
2012 Impact Factor: 1.009
2012 SCImago Journal Rankings: 0.499
 
dc.identifier.issue4
 
dc.identifier.openurl
 
dc.identifier.pmid19962878
 
dc.identifier.scopuseid_2-s2.0-78049486766
 
dc.identifier.spage255
 
dc.identifier.urihttp://hdl.handle.net/10722/124621
 
dc.identifier.volume35
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/meddos
 
dc.publisher.placeUnited States
 
dc.relation.ispartofMedical Dosimetry
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshBody Burden
 
dc.subject.meshChild
 
dc.subject.meshChild, Preschool
 
dc.subject.meshFemale
 
dc.subject.meshHead and Neck Neoplasms - radiotherapy
 
dc.subject.meshHumans
 
dc.subject.meshInfant
 
dc.subject.meshMale
 
dc.subject.meshRadiotherapy, Conformal - methods
 
dc.subject.meshWhole-Body Counting - methods
 
dc.titlePeripheral Doses from Noncoplanar IMRT for Pediatric Radiation Therapy
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong