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Article: Photodynamic therapy-mediated modulation of inflammatory cytokine production by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

TitlePhotodynamic therapy-mediated modulation of inflammatory cytokine production by Epstein-Barr virus-infected nasopharyngeal carcinoma cells
Authors
Keywordscytokines
Epstein-Barr virus
nasopharyngeal carcinoma
Photodynamic therapy
Issue Date2010
PublisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
Citation
Cellular And Molecular Immunology, 2010, v. 7 n. 4, p. 323-326 How to Cite?
AbstractNasopharyngeal carcinoma (NPC) is a malignant disease associated with Epstein-Barr virus (EBV) infection. This study aims to examine the effects of EBV infection on the production of proinflammatory cytokines in NPC cells after the Zn-BC-AM photodynamic therapy (PDT) treatment. Cells were treated with the photosensitiser Zn-BC-AM for 24 h before light irradiation. Quantitative ELISA was used to evaluate the production of cytokines. Under the same experimental condition, HK-1-EBV cells produced a higher basal level of IL-1α (1561 pg/ml), IL-1Β (16.6 pg/ml) and IL-8 (422.9 pg/ml) than the HK-1 cells. At the light dose of 0.25-0.5 J/cm 2, Zn-BC-AM PDT-treated HK-1-EBV cells were found to produce a higher level of IL-1α and IL-1Β than the HK-1 cells. The production of IL-1Β appeared to be mediated via the IL-1Β-converting enzyme (ICE)-independent pathway. In contrast, the production of angiogenic IL-8 was downregulated in both HK-1 and HK-1-EBV cells after Zn-BC-AM PDT. Our results suggest that Zn-BC-AM PDT might indirectly reduce tumour growth through the modulation of cytokine production. © 2010 CSI and USTC. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/124616
ISSN
2015 Impact Factor: 5.193
2015 SCImago Journal Rankings: 1.898
ISI Accession Number ID
Funding AgencyGrant Number
Research Grant Council of Hong KongHKBU2052/02M
HKBU2458/06M
Funding Information:

This work was partly supported by the Research Grant Council of Hong Kong (HKBU2052/02M and HKBU2458/06M).

References

 

DC FieldValueLanguage
dc.contributor.authorKoon, HKen_HK
dc.contributor.authorLo, KWen_HK
dc.contributor.authorLeung, KNen_HK
dc.contributor.authorLung, MLen_HK
dc.contributor.authorChang, CCKen_HK
dc.contributor.authorWong, RNSen_HK
dc.contributor.authorLeung, WNen_HK
dc.contributor.authorMak, NKen_HK
dc.date.accessioned2010-10-31T10:44:26Z-
dc.date.available2010-10-31T10:44:26Z-
dc.date.issued2010en_HK
dc.identifier.citationCellular And Molecular Immunology, 2010, v. 7 n. 4, p. 323-326en_HK
dc.identifier.issn1672-7681en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124616-
dc.description.abstractNasopharyngeal carcinoma (NPC) is a malignant disease associated with Epstein-Barr virus (EBV) infection. This study aims to examine the effects of EBV infection on the production of proinflammatory cytokines in NPC cells after the Zn-BC-AM photodynamic therapy (PDT) treatment. Cells were treated with the photosensitiser Zn-BC-AM for 24 h before light irradiation. Quantitative ELISA was used to evaluate the production of cytokines. Under the same experimental condition, HK-1-EBV cells produced a higher basal level of IL-1α (1561 pg/ml), IL-1Β (16.6 pg/ml) and IL-8 (422.9 pg/ml) than the HK-1 cells. At the light dose of 0.25-0.5 J/cm 2, Zn-BC-AM PDT-treated HK-1-EBV cells were found to produce a higher level of IL-1α and IL-1Β than the HK-1 cells. The production of IL-1Β appeared to be mediated via the IL-1Β-converting enzyme (ICE)-independent pathway. In contrast, the production of angiogenic IL-8 was downregulated in both HK-1 and HK-1-EBV cells after Zn-BC-AM PDT. Our results suggest that Zn-BC-AM PDT might indirectly reduce tumour growth through the modulation of cytokine production. © 2010 CSI and USTC. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.htmlen_HK
dc.relation.ispartofCellular and Molecular Immunologyen_HK
dc.subjectcytokinesen_HK
dc.subjectEpstein-Barr virusen_HK
dc.subjectnasopharyngeal carcinomaen_HK
dc.subjectPhotodynamic therapyen_HK
dc.titlePhotodynamic therapy-mediated modulation of inflammatory cytokine production by Epstein-Barr virus-infected nasopharyngeal carcinoma cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailLung, ML:mlilung@hku.hken_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/cmi.2010.4en_HK
dc.identifier.pmid20228836-
dc.identifier.scopuseid_2-s2.0-77957266945en_HK
dc.identifier.hkuros174226en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957266945&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue4en_HK
dc.identifier.spage323en_HK
dc.identifier.epage326en_HK
dc.identifier.isiWOS:000279487500012-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridKoon, HK=12766487800en_HK
dc.identifier.scopusauthoridLo, KW=34872774800en_HK
dc.identifier.scopusauthoridLeung, KN=7401860476en_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK
dc.identifier.scopusauthoridChang, CCK=38961018200en_HK
dc.identifier.scopusauthoridWong, RNS=35270797800en_HK
dc.identifier.scopusauthoridLeung, WN=7201504470en_HK
dc.identifier.scopusauthoridMak, NK=37034545600en_HK

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