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Article: Lack of association between the GRP78 polymorphisms in the promoter and 3' UTR and susceptibility to chronic HBV infection in a Chinese Han population

TitleLack of association between the GRP78 polymorphisms in the promoter and 3' UTR and susceptibility to chronic HBV infection in a Chinese Han population
Authors
Issue Date2010
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcmedgenet/
Citation
Bmc Medical Genetics, 2010, v. 11 n. 1, article no. 83 How to Cite?
AbstractBackground: Hepatitis B virus (HBV) infection causes large amount of unfolding or false-folding protein accumulation in the endoplasmic reticulum (ER), which in turn induces the expression of glucose-regulated protein 78 (GRP78). The aim in the present study was to analyse the potential association between GRP78 single-nucleotide polymorphisms (SNPs) and the risk of HBV infection.Methods: The associations between seven common GRP78 polymorphisms in the promoter (rs391957, rs17840762, rs17840761, rs11355458) and in the 3' untranslated region (UTR) (rs16927997, rs1140763, rs12009) and possible risk of chronic HBV infection were assessed in a case-control study. 496 cases and 539 individually matched healthy controls were genotyped.Results: Overall, no associations were observed in genotypic analyses. In addition, haplotypes and diplotypes combining those SNPs in the promoter or in the 3' UTR in high linkage disequilibrium (LD) were also not associated with HBV risk.Conclusion: These observations do not support a role for GRP78 polymorphisms in HBV infection in a predominantly Chinese Han population. © 2010 Zhu et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/124533
ISSN
2015 Impact Factor: 2.094
2015 SCImago Journal Rankings: 1.062
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Guangzhou Medical College
Funding Information:

We are grateful to all the patients and the physicians who were involved in sample collection for the study. This work was supported by direct grant from Guangzhou Medical College.

References

 

DC FieldValueLanguage
dc.contributor.authorZhu, Xen_HK
dc.contributor.authorLi, DPen_HK
dc.contributor.authorFan, WGen_HK
dc.contributor.authorLin, MCMen_HK
dc.contributor.authorWang, JLen_HK
dc.contributor.authorLin, SQen_HK
dc.contributor.authorHuang, JQen_HK
dc.contributor.authorKung, HFen_HK
dc.date.accessioned2010-10-31T10:39:51Z-
dc.date.available2010-10-31T10:39:51Z-
dc.date.issued2010en_HK
dc.identifier.citationBmc Medical Genetics, 2010, v. 11 n. 1, article no. 83en_HK
dc.identifier.issn1471-2350en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124533-
dc.description.abstractBackground: Hepatitis B virus (HBV) infection causes large amount of unfolding or false-folding protein accumulation in the endoplasmic reticulum (ER), which in turn induces the expression of glucose-regulated protein 78 (GRP78). The aim in the present study was to analyse the potential association between GRP78 single-nucleotide polymorphisms (SNPs) and the risk of HBV infection.Methods: The associations between seven common GRP78 polymorphisms in the promoter (rs391957, rs17840762, rs17840761, rs11355458) and in the 3' untranslated region (UTR) (rs16927997, rs1140763, rs12009) and possible risk of chronic HBV infection were assessed in a case-control study. 496 cases and 539 individually matched healthy controls were genotyped.Results: Overall, no associations were observed in genotypic analyses. In addition, haplotypes and diplotypes combining those SNPs in the promoter or in the 3' UTR in high linkage disequilibrium (LD) were also not associated with HBV risk.Conclusion: These observations do not support a role for GRP78 polymorphisms in HBV infection in a predominantly Chinese Han population. © 2010 Zhu et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcmedgenet/en_HK
dc.relation.ispartofBMC Medical Geneticsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsB M C Medical Genetics. Copyright © BioMed Central Ltd.-
dc.subject.mesh3' Untranslated Regions-
dc.subject.meshAsian Continental Ancestry Group - genetics-
dc.subject.meshHepatitis B - genetics-
dc.subject.meshHepatitis B, Chronic - genetics-
dc.subject.meshPolymorphism, Genetic-
dc.titleLack of association between the GRP78 polymorphisms in the promoter and 3' UTR and susceptibility to chronic HBV infection in a Chinese Han populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1471-2350&volume=11 article no. 83&spage=&epage=&date=2010&atitle=Lack+of+association+between+the+GRP78+polymorphisms+in+the+promoter+and+3%27+UTR+and+susceptibility+to+chronic+HBV+infection+in+a+Chinese+Han+population-
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1471-2350-11-83en_HK
dc.identifier.pmid20525207-
dc.identifier.pmcidPMC2901214-
dc.identifier.scopuseid_2-s2.0-77952798898en_HK
dc.identifier.hkuros181310en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952798898&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue1, article no. 83en_HK
dc.identifier.isiWOS:000279920400001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZhu, X=23491117800en_HK
dc.identifier.scopusauthoridLi, DP=24463373900en_HK
dc.identifier.scopusauthoridFan, WG=24070406000en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK
dc.identifier.scopusauthoridWang, JL=36172185600en_HK
dc.identifier.scopusauthoridLin, SQ=35792140300en_HK
dc.identifier.scopusauthoridHuang, JQ=36171590100en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK

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