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Article: Aqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression

TitleAqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression
Authors
Keywordsapoptosis
doxorubicin
Fructus Ligustri Lucidi
sensitivity
Issue Date2011
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201510
Citation
Integrative Cancer Therapies, 2011, v. 10 n. 1, p. 85-91 How to Cite?
Abstract
Chemoresistance has imposed a great challenge for cancer therapy. Fructus Ligustri Lucidi (FLL) is one of the commonest Chinese herbs that has been used for thousand years. This study shows that the aqueous extract of FLL (AFLL) enhanced the sensitivity of DLD-1 colon cancer cells to doxorubicin-induced apoptosis. Furthermore, Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were activated. Therefore, reduction of Tbx3 rescued the dysregulated P14 ARF-P53 signaling, which in turn contributed to the sensitivity of DLD-1 cells to doxorubicin-induced apoptosis. As a conclusion, the findings suggest that FLL has a potential of being an appealing agent for auxiliary chemotherapy in treatment of human colorectal carcinoma. © The Author(s) 2011.
Persistent Identifierhttp://hdl.handle.net/10722/124531
ISSN
2013 Impact Factor: 2.014
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, JFen_HK
dc.contributor.authorHe, MLen_HK
dc.contributor.authorDong, Qen_HK
dc.contributor.authorXie, WDen_HK
dc.contributor.authorChen, YCen_HK
dc.contributor.authorLin, MCMen_HK
dc.contributor.authorLeung, PCen_HK
dc.contributor.authorZhang, YOen_HK
dc.contributor.authorKung, HFen_HK
dc.date.accessioned2010-10-31T10:39:44Z-
dc.date.available2010-10-31T10:39:44Z-
dc.date.issued2011en_HK
dc.identifier.citationIntegrative Cancer Therapies, 2011, v. 10 n. 1, p. 85-91en_HK
dc.identifier.issn1534-7354en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124531-
dc.description.abstractChemoresistance has imposed a great challenge for cancer therapy. Fructus Ligustri Lucidi (FLL) is one of the commonest Chinese herbs that has been used for thousand years. This study shows that the aqueous extract of FLL (AFLL) enhanced the sensitivity of DLD-1 colon cancer cells to doxorubicin-induced apoptosis. Furthermore, Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were activated. Therefore, reduction of Tbx3 rescued the dysregulated P14 ARF-P53 signaling, which in turn contributed to the sensitivity of DLD-1 cells to doxorubicin-induced apoptosis. As a conclusion, the findings suggest that FLL has a potential of being an appealing agent for auxiliary chemotherapy in treatment of human colorectal carcinoma. © The Author(s) 2011.en_HK
dc.languageengen_HK
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201510en_HK
dc.relation.ispartofIntegrative Cancer Therapiesen_HK
dc.rightsIntegrative Cancer Therapies. Copyright © Sage Publications, Inc..-
dc.subjectapoptosisen_HK
dc.subjectdoxorubicinen_HK
dc.subjectFructus Ligustri Lucidien_HK
dc.subjectsensitivityen_HK
dc.titleAqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppressionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1534-7354&volume=9&issue=4&spage=354&epage=364&date=2010&atitle=Aqueous+Extracts+of+Fructus+Ligustri+Lucidi+Enhance+the+Sensitivity+of+Human+Colorectal+Carcionma+DLD-1+Cells+to+Doxorubicin-Induced+Apoptosis+via+Tbx3+Suppressionen_HK
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/1534735410373921en_HK
dc.identifier.pmid20702496en_HK
dc.identifier.scopuseid_2-s2.0-79953728787en_HK
dc.identifier.hkuros181309en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79953728787&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue1en_HK
dc.identifier.spage85en_HK
dc.identifier.epage91en_HK
dc.identifier.isiWOS:000289157000009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, JF=13007942600en_HK
dc.identifier.scopusauthoridHe, ML=35080389700en_HK
dc.identifier.scopusauthoridDong, Q=37033806100en_HK
dc.identifier.scopusauthoridXie, WD=35081557300en_HK
dc.identifier.scopusauthoridChen, YC=7601431852en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK
dc.identifier.scopusauthoridLeung, PC=7401747829en_HK
dc.identifier.scopusauthoridZhang, YO=47861579300en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK

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