File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Aqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression
  • Basic View
  • Metadata View
  • XML View
TitleAqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression
 
AuthorsZhang, JF2 3
He, ML3
Dong, Q3
Xie, WD2
Chen, YC3
Lin, MCM1
Leung, PC3
Zhang, YO2
Kung, HF2 3
 
Keywordsapoptosis
doxorubicin
Fructus Ligustri Lucidi
sensitivity
 
Issue Date2011
 
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201510
 
CitationIntegrative Cancer Therapies, 2011, v. 10 n. 1, p. 85-91 [How to Cite?]
DOI: http://dx.doi.org/10.1177/1534735410373921
 
AbstractChemoresistance has imposed a great challenge for cancer therapy. Fructus Ligustri Lucidi (FLL) is one of the commonest Chinese herbs that has been used for thousand years. This study shows that the aqueous extract of FLL (AFLL) enhanced the sensitivity of DLD-1 colon cancer cells to doxorubicin-induced apoptosis. Furthermore, Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were activated. Therefore, reduction of Tbx3 rescued the dysregulated P14 ARF-P53 signaling, which in turn contributed to the sensitivity of DLD-1 cells to doxorubicin-induced apoptosis. As a conclusion, the findings suggest that FLL has a potential of being an appealing agent for auxiliary chemotherapy in treatment of human colorectal carcinoma. © The Author(s) 2011.
 
ISSN1534-7354
2013 Impact Factor: 2.014
 
DOIhttp://dx.doi.org/10.1177/1534735410373921
 
ISI Accession Number IDWOS:000289157000009
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhang, JF
 
dc.contributor.authorHe, ML
 
dc.contributor.authorDong, Q
 
dc.contributor.authorXie, WD
 
dc.contributor.authorChen, YC
 
dc.contributor.authorLin, MCM
 
dc.contributor.authorLeung, PC
 
dc.contributor.authorZhang, YO
 
dc.contributor.authorKung, HF
 
dc.date.accessioned2010-10-31T10:39:44Z
 
dc.date.available2010-10-31T10:39:44Z
 
dc.date.issued2011
 
dc.description.abstractChemoresistance has imposed a great challenge for cancer therapy. Fructus Ligustri Lucidi (FLL) is one of the commonest Chinese herbs that has been used for thousand years. This study shows that the aqueous extract of FLL (AFLL) enhanced the sensitivity of DLD-1 colon cancer cells to doxorubicin-induced apoptosis. Furthermore, Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were activated. Therefore, reduction of Tbx3 rescued the dysregulated P14 ARF-P53 signaling, which in turn contributed to the sensitivity of DLD-1 cells to doxorubicin-induced apoptosis. As a conclusion, the findings suggest that FLL has a potential of being an appealing agent for auxiliary chemotherapy in treatment of human colorectal carcinoma. © The Author(s) 2011.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationIntegrative Cancer Therapies, 2011, v. 10 n. 1, p. 85-91 [How to Cite?]
DOI: http://dx.doi.org/10.1177/1534735410373921
 
dc.identifier.doihttp://dx.doi.org/10.1177/1534735410373921
 
dc.identifier.epage91
 
dc.identifier.hkuros181309
 
dc.identifier.isiWOS:000289157000009
 
dc.identifier.issn1534-7354
2013 Impact Factor: 2.014
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid20702496
 
dc.identifier.scopuseid_2-s2.0-79953728787
 
dc.identifier.spage85
 
dc.identifier.urihttp://hdl.handle.net/10722/124531
 
dc.identifier.volume10
 
dc.languageeng
 
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201510
 
dc.publisher.placeUnited States
 
dc.relation.ispartofIntegrative Cancer Therapies
 
dc.relation.referencesReferences in Scopus
 
dc.rightsIntegrative Cancer Therapies. Copyright © Sage Publications, Inc..
 
dc.subjectapoptosis
 
dc.subjectdoxorubicin
 
dc.subjectFructus Ligustri Lucidi
 
dc.subjectsensitivity
 
dc.titleAqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Zhang, JF</contributor.author>
<contributor.author>He, ML</contributor.author>
<contributor.author>Dong, Q</contributor.author>
<contributor.author>Xie, WD</contributor.author>
<contributor.author>Chen, YC</contributor.author>
<contributor.author>Lin, MCM</contributor.author>
<contributor.author>Leung, PC</contributor.author>
<contributor.author>Zhang, YO</contributor.author>
<contributor.author>Kung, HF</contributor.author>
<date.accessioned>2010-10-31T10:39:44Z</date.accessioned>
<date.available>2010-10-31T10:39:44Z</date.available>
<date.issued>2011</date.issued>
<identifier.citation>Integrative Cancer Therapies, 2011, v. 10 n. 1, p. 85-91</identifier.citation>
<identifier.issn>1534-7354</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/124531</identifier.uri>
<description.abstract>Chemoresistance has imposed a great challenge for cancer therapy. Fructus Ligustri Lucidi (FLL) is one of the commonest Chinese herbs that has been used for thousand years. This study shows that the aqueous extract of FLL (AFLL) enhanced the sensitivity of DLD-1 colon cancer cells to doxorubicin-induced apoptosis. Furthermore, Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were activated. Therefore, reduction of Tbx3 rescued the dysregulated P14 ARF-P53 signaling, which in turn contributed to the sensitivity of DLD-1 cells to doxorubicin-induced apoptosis. As a conclusion, the findings suggest that FLL has a potential of being an appealing agent for auxiliary chemotherapy in treatment of human colorectal carcinoma. &#169; The Author(s) 2011.</description.abstract>
<language>eng</language>
<publisher>Sage Publications, Inc.. The Journal&apos;s web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201510</publisher>
<relation.ispartof>Integrative Cancer Therapies</relation.ispartof>
<rights>Integrative Cancer Therapies. Copyright &#169; Sage Publications, Inc..</rights>
<subject>apoptosis</subject>
<subject>doxorubicin</subject>
<subject>Fructus Ligustri Lucidi</subject>
<subject>sensitivity</subject>
<title>Aqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=1534-7354&amp;volume=9&amp;issue=4&amp;spage=354&amp;epage=364&amp;date=2010&amp;atitle=Aqueous+Extracts+of+Fructus+Ligustri+Lucidi+Enhance+the+Sensitivity+of+Human+Colorectal+Carcionma+DLD-1+Cells+to+Doxorubicin-Induced+Apoptosis+via+Tbx3+Suppression</identifier.openurl>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1177/1534735410373921</identifier.doi>
<identifier.pmid>20702496</identifier.pmid>
<identifier.scopus>eid_2-s2.0-79953728787</identifier.scopus>
<identifier.hkuros>181309</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-79953728787&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>10</identifier.volume>
<identifier.issue>1</identifier.issue>
<identifier.spage>85</identifier.spage>
<identifier.epage>91</identifier.epage>
<identifier.isi>WOS:000289157000009</identifier.isi>
<publisher.place>United States</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Tsinghua University
  3. Chinese University of Hong Kong