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Article: Evaluation of serum clusterin as a surveillance tool for human hepatocellular carcinoma with hepatitis B virus related cirrhosis

TitleEvaluation of serum clusterin as a surveillance tool for human hepatocellular carcinoma with hepatitis B virus related cirrhosis
Authors
Issue Date2010
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 2010, v. 25 n. 6, p. 1123-1128 How to Cite?
Abstract
Background and Aim: Hepatocellular carcinoma (HCC) is a common human cancer worldwide. The levels of serum clusterin in HCC patients and its potential diagnostic significance is not clear. We aimed to evaluate the clinical use of serum clusterin levels as a surveillance tool for HCC with hepatitis B virus (HBV) related cirrhosis. Methods: Twenty-two cases of healthy subjects, 31 cases of HBV carriers, 26 patients with chronic hepatitis B, 29 patients with cirrhosis, and 76 patients with HCC were enrolled in this study. Serum levels of clusterin were measured by a sandwich enzyme-linked immunosorbent assay. Results: The serum clusterin levels in HCC patients were significantly lower than that in healthy, HBV carriers and chronic hepatitis B, but statistically higher than in cirrhosis patients. Receiver operator characteristic (ROC) curve indicated that a serum clusterin value of 50 μg/mL yielded the best sensitivity (91%) and specificity (83%) for differentiating HCC patients with HBV-related cirrhosis from those with HBV-related cirrhosis. The optimal alpha fetoprotein (AFP) cutoff value was 15 ng/mL and was inferior to the clusterin value of 50 μg/mL, the area under the ROC curves being 0.937 versus 0.781, respectively (P < 0.05). Conclusions: Serum clusterin was more sensitive and specific than serum AFP for differentiating HCC patients with HBV-related cirrhosis from those with HBV-related liver cirrhosis, and may be a useful surveillance tool of HCC based on HBV-related cirrhosis. © 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/124521
ISSN
2013 Impact Factor: 3.627
ISI Accession Number ID
Funding AgencyGrant Number
Foundation of Guangzhou Science and Technology Bureau2005Z1-E0131
Major State Basic Research Program of China2006CB910104
863 Project of China2007AA021901
Funding Information:

This study was supported by the Foundation of Guangzhou Science and Technology Bureau (2005Z1-E0131), the Major State Basic Research Program of China (2006CB910104) and the 863 Project of China (2007AA021901)

References

 

Author Affiliations
  1. Guangdong Provincial People's Hospital
  2. Sun Yat-Sen University
DC FieldValueLanguage
dc.contributor.authorWang, Yen_HK
dc.contributor.authorLiu, YHen_HK
dc.contributor.authorMai, SJen_HK
dc.contributor.authorHe, LJen_HK
dc.contributor.authorLiao, YJen_HK
dc.contributor.authorDeng, HXen_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorZeng, YXen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorXie, Den_HK
dc.date.accessioned2010-10-31T10:39:07Z-
dc.date.available2010-10-31T10:39:07Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2010, v. 25 n. 6, p. 1123-1128en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124521-
dc.description.abstractBackground and Aim: Hepatocellular carcinoma (HCC) is a common human cancer worldwide. The levels of serum clusterin in HCC patients and its potential diagnostic significance is not clear. We aimed to evaluate the clinical use of serum clusterin levels as a surveillance tool for HCC with hepatitis B virus (HBV) related cirrhosis. Methods: Twenty-two cases of healthy subjects, 31 cases of HBV carriers, 26 patients with chronic hepatitis B, 29 patients with cirrhosis, and 76 patients with HCC were enrolled in this study. Serum levels of clusterin were measured by a sandwich enzyme-linked immunosorbent assay. Results: The serum clusterin levels in HCC patients were significantly lower than that in healthy, HBV carriers and chronic hepatitis B, but statistically higher than in cirrhosis patients. Receiver operator characteristic (ROC) curve indicated that a serum clusterin value of 50 μg/mL yielded the best sensitivity (91%) and specificity (83%) for differentiating HCC patients with HBV-related cirrhosis from those with HBV-related cirrhosis. The optimal alpha fetoprotein (AFP) cutoff value was 15 ng/mL and was inferior to the clusterin value of 50 μg/mL, the area under the ROC curves being 0.937 versus 0.781, respectively (P < 0.05). Conclusions: Serum clusterin was more sensitive and specific than serum AFP for differentiating HCC patients with HBV-related cirrhosis from those with HBV-related liver cirrhosis, and may be a useful surveillance tool of HCC based on HBV-related cirrhosis. © 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.subject.meshCarcinoma, Hepatocellular - blood - complications - epidemiologyen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshClusterin - blooden_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHepatitis B, Chronic - blood - complications - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Cirrhosis - blood - epidemiology - virologyen_HK
dc.subject.meshLiver Neoplasms - blood - complications - epidemiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshalpha-Fetoproteins - metabolismen_HK
dc.titleEvaluation of serum clusterin as a surveillance tool for human hepatocellular carcinoma with hepatitis B virus related cirrhosisen_HK
dc.typeArticleen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1746.2009.06205.xen_HK
dc.identifier.pmid20594228en_HK
dc.identifier.scopuseid_2-s2.0-77952963730en_HK
dc.identifier.hkuros175309en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952963730&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1123en_HK
dc.identifier.epage1128en_HK
dc.identifier.isiWOS:000278110500019-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridWang, Y=10641308400en_HK
dc.identifier.scopusauthoridLiu, YH=26643415800en_HK
dc.identifier.scopusauthoridMai, SJ=36780688900en_HK
dc.identifier.scopusauthoridHe, LJ=8642044900en_HK
dc.identifier.scopusauthoridLiao, YJ=36114448500en_HK
dc.identifier.scopusauthoridDeng, HX=24079601100en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridZeng, YX=7402981579en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.citeulike7277171-

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