Article: Evaluation of serum clusterin as a surveillance tool for human hepatocellular carcinoma with hepatitis B virus related cirrhosis

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TitleEvaluation of serum clusterin as a surveillance tool for human hepatocellular carcinoma with hepatitis B virus related cirrhosis
AuthorsWang, Y2
Liu, YH1
Mai, SJ2
He, LJ2
Liao, YJ2
Deng, HX2
Guan, XY2
Zeng, YX2
Kung, HF2
Xie, D2
Issue Date2010
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
CitationJournal Of Gastroenterology And Hepatology, 2010, v. 25 n. 6, p. 1123-1128 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1440-1746.2009.06205.x
AbstractBackground and Aim: Hepatocellular carcinoma (HCC) is a common human cancer worldwide. The levels of serum clusterin in HCC patients and its potential diagnostic significance is not clear. We aimed to evaluate the clinical use of serum clusterin levels as a surveillance tool for HCC with hepatitis B virus (HBV) related cirrhosis. Methods: Twenty-two cases of healthy subjects, 31 cases of HBV carriers, 26 patients with chronic hepatitis B, 29 patients with cirrhosis, and 76 patients with HCC were enrolled in this study. Serum levels of clusterin were measured by a sandwich enzyme-linked immunosorbent assay. Results: The serum clusterin levels in HCC patients were significantly lower than that in healthy, HBV carriers and chronic hepatitis B, but statistically higher than in cirrhosis patients. Receiver operator characteristic (ROC) curve indicated that a serum clusterin value of 50 μg/mL yielded the best sensitivity (91%) and specificity (83%) for differentiating HCC patients with HBV-related cirrhosis from those with HBV-related cirrhosis. The optimal alpha fetoprotein (AFP) cutoff value was 15 ng/mL and was inferior to the clusterin value of 50 μg/mL, the area under the ROC curves being 0.937 versus 0.781, respectively (P < 0.05). Conclusions: Serum clusterin was more sensitive and specific than serum AFP for differentiating HCC patients with HBV-related cirrhosis from those with HBV-related liver cirrhosis, and may be a useful surveillance tool of HCC based on HBV-related cirrhosis. © 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
ISSN0815-9319
2011 Impact Factor: 2.865
2011 SCImago Journal Rankings: 0.208
DOIhttp://dx.doi.org/10.1111/j.1440-1746.2009.06205.x
ISI Accession Number IDWOS:000278110500019
Funding AgencyGrant Number
Foundation of Guangzhou Science and Technology Bureau2005Z1-E0131
Major State Basic Research Program of China2006CB910104
863 Project of China2007AA021901
Funding Information:

This study was supported by the Foundation of Guangzhou Science and Technology Bureau (2005Z1-E0131), the Major State Basic Research Program of China (2006CB910104) and the 863 Project of China (2007AA021901)

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWang, Y
dc.contributor.authorLiu, YH
dc.contributor.authorMai, SJ
dc.contributor.authorHe, LJ
dc.contributor.authorLiao, YJ
dc.contributor.authorDeng, HX
dc.contributor.authorGuan, XY
dc.contributor.authorZeng, YX
dc.contributor.authorKung, HF
dc.contributor.authorXie, D
dc.date.accessioned2010-10-31T10:39:07Z
dc.date.available2010-10-31T10:39:07Z
dc.date.issued2010
dc.description.abstractBackground and Aim: Hepatocellular carcinoma (HCC) is a common human cancer worldwide. The levels of serum clusterin in HCC patients and its potential diagnostic significance is not clear. We aimed to evaluate the clinical use of serum clusterin levels as a surveillance tool for HCC with hepatitis B virus (HBV) related cirrhosis. Methods: Twenty-two cases of healthy subjects, 31 cases of HBV carriers, 26 patients with chronic hepatitis B, 29 patients with cirrhosis, and 76 patients with HCC were enrolled in this study. Serum levels of clusterin were measured by a sandwich enzyme-linked immunosorbent assay. Results: The serum clusterin levels in HCC patients were significantly lower than that in healthy, HBV carriers and chronic hepatitis B, but statistically higher than in cirrhosis patients. Receiver operator characteristic (ROC) curve indicated that a serum clusterin value of 50 μg/mL yielded the best sensitivity (91%) and specificity (83%) for differentiating HCC patients with HBV-related cirrhosis from those with HBV-related cirrhosis. The optimal alpha fetoprotein (AFP) cutoff value was 15 ng/mL and was inferior to the clusterin value of 50 μg/mL, the area under the ROC curves being 0.937 versus 0.781, respectively (P < 0.05). Conclusions: Serum clusterin was more sensitive and specific than serum AFP for differentiating HCC patients with HBV-related cirrhosis from those with HBV-related liver cirrhosis, and may be a useful surveillance tool of HCC based on HBV-related cirrhosis. © 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2010, v. 25 n. 6, p. 1123-1128 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1440-1746.2009.06205.x
dc.identifier.citeulike7277171
dc.identifier.doihttp://dx.doi.org/10.1111/j.1440-1746.2009.06205.x
dc.identifier.epage1128
dc.identifier.hkuros175309
dc.identifier.isiWOS:000278110500019
Funding AgencyGrant Number
Foundation of Guangzhou Science and Technology Bureau2005Z1-E0131
Major State Basic Research Program of China2006CB910104
863 Project of China2007AA021901
Funding Information:

This study was supported by the Foundation of Guangzhou Science and Technology Bureau (2005Z1-E0131), the Major State Basic Research Program of China (2006CB910104) and the 863 Project of China (2007AA021901)

dc.identifier.issn0815-9319
2011 Impact Factor: 2.865
2011 SCImago Journal Rankings: 0.208
dc.identifier.issue6
dc.identifier.pmid20594228
dc.identifier.scopuseid_2-s2.0-77952963730
dc.identifier.spage1123
dc.identifier.urihttp://hdl.handle.net/10722/124521
dc.identifier.volume25
dc.languageeng
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
dc.publisher.placeAustralia
dc.relation.ispartofJournal of Gastroenterology and Hepatology
dc.relation.referencesReferences in Scopus
dc.subject.meshCarcinoma, Hepatocellular - blood - complications - epidemiology
dc.subject.meshChina - epidemiology
dc.subject.meshClusterin - blood
dc.subject.meshDisease Progression
dc.subject.meshEnzyme-Linked Immunosorbent Assay
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHepatitis B, Chronic - blood - complications - epidemiology
dc.subject.meshHumans
dc.subject.meshLiver Cirrhosis - blood - epidemiology - virology
dc.subject.meshLiver Neoplasms - blood - complications - epidemiology
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPrevalence
dc.subject.meshPrognosis
dc.subject.meshRetrospective Studies
dc.subject.meshSensitivity and Specificity
dc.subject.meshalpha-Fetoproteins - metabolism
dc.titleEvaluation of serum clusterin as a surveillance tool for human hepatocellular carcinoma with hepatitis B virus related cirrhosis
dc.typeArticle
Author Affiliations
  1. Guangdong Provincial People's Hospital
  2. Sun Yat-Sen University