File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effect of a non-hydrolyzable analog of diadenosine polyphosphates on NMDA-mediated currents in isolated pyramidal neurons of the rat hippocampus

TitleEffect of a non-hydrolyzable analog of diadenosine polyphosphates on NMDA-mediated currents in isolated pyramidal neurons of the rat hippocampus
Authors
KeywordsDiadenosine polyphosphates
Hippocampus
NMDA
Purinoceptors
Pyramidal neurons
Tyrosine kinase
Zinc
Issue Date2006
PublisherS U B I S.
Citation
Neurophysiology, 2006, v. 38 n. 3, p. 169-174 How to Cite?
AbstractUsing a patch-clamp technique under voltage clamp conditions, we studied the effect of a non-hydrolyzable analog of diadenosine polyphosphates (AppCH2ppAs) on chemoactivated transmembrane currents through NMDA channels (NMDA currents) in isolated pyramidal neurons of the rat hippocampal CA3 zone. In 55.7% of the cases, AppCH2ppAs caused an increase in the peak amplitude of the currents induced by application of aspartate. In 39.5% of the cases, the agent exerted no effect, while in 4.8% these currents were suppressed. When studying the pharmacological effect of an increase in the amplitude of NMDA currents, we found that potentiation of these currents is mediated, first of all, by activation of P2 purinoceptors and is prevented by a blocker of tyrosine kinases, genistein. Receptor-channel NMDA complexes, due to their ability to be blocked by divalent cations, also contribute to the above effect of AppCH2ppA. Based on the data obtained, we conclude that AppCH2ppA influences NMDA receptors via activation of the P2 receptors and subsequent activation of tyrosine kinases; this leads to the modification of receptor-channel NMDA complexes and to the removal of their tonic blocking by zinc ions. © Springer Science+Business Media, Inc. 2006.
Persistent Identifierhttp://hdl.handle.net/10722/124516
ISSN
2015 Impact Factor: 0.2
2015 SCImago Journal Rankings: 0.168
References

 

DC FieldValueLanguage
dc.contributor.authorTsintsadze, VPen_HK
dc.contributor.authorFedorenko, ALen_HK
dc.contributor.authorTsintsadze, TShen_HK
dc.contributor.authorWright, Men_HK
dc.contributor.authorTanner, JAen_HK
dc.contributor.authorMiller, ADen_HK
dc.contributor.authorLozovaya, NAen_HK
dc.date.accessioned2010-10-31T10:38:50Z-
dc.date.available2010-10-31T10:38:50Z-
dc.date.issued2006en_HK
dc.identifier.citationNeurophysiology, 2006, v. 38 n. 3, p. 169-174en_HK
dc.identifier.issn0090-2977en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124516-
dc.description.abstractUsing a patch-clamp technique under voltage clamp conditions, we studied the effect of a non-hydrolyzable analog of diadenosine polyphosphates (AppCH2ppAs) on chemoactivated transmembrane currents through NMDA channels (NMDA currents) in isolated pyramidal neurons of the rat hippocampal CA3 zone. In 55.7% of the cases, AppCH2ppAs caused an increase in the peak amplitude of the currents induced by application of aspartate. In 39.5% of the cases, the agent exerted no effect, while in 4.8% these currents were suppressed. When studying the pharmacological effect of an increase in the amplitude of NMDA currents, we found that potentiation of these currents is mediated, first of all, by activation of P2 purinoceptors and is prevented by a blocker of tyrosine kinases, genistein. Receptor-channel NMDA complexes, due to their ability to be blocked by divalent cations, also contribute to the above effect of AppCH2ppA. Based on the data obtained, we conclude that AppCH2ppA influences NMDA receptors via activation of the P2 receptors and subsequent activation of tyrosine kinases; this leads to the modification of receptor-channel NMDA complexes and to the removal of their tonic blocking by zinc ions. © Springer Science+Business Media, Inc. 2006.en_HK
dc.languageengen_HK
dc.publisherS U B I S.-
dc.relation.ispartofNeurophysiologyen_HK
dc.subjectDiadenosine polyphosphatesen_HK
dc.subjectHippocampusen_HK
dc.subjectNMDAen_HK
dc.subjectPurinoceptorsen_HK
dc.subjectPyramidal neuronsen_HK
dc.subjectTyrosine kinaseen_HK
dc.subjectZincen_HK
dc.titleEffect of a non-hydrolyzable analog of diadenosine polyphosphates on NMDA-mediated currents in isolated pyramidal neurons of the rat hippocampusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0142-8241&volume=38&issue=3&spage=169&epage=174&date=2006&atitle=Effect+of+a+non-hydrolyzable+analog+of+diadenosine+polyphosphates+on+NMDA-mediated+currents+in+isolated+pyramidal+neurons+of+the+rat+hippocampusen_HK
dc.identifier.emailTanner, JA:jatanner@hku.hken_HK
dc.identifier.authorityTanner, JA=rp00495en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11062-006-0041-yen_HK
dc.identifier.scopuseid_2-s2.0-37849188621en_HK
dc.identifier.hkuros178699en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37849188621&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue3en_HK
dc.identifier.spage169en_HK
dc.identifier.epage174en_HK
dc.identifier.scopusauthoridTsintsadze, VP=14039705700en_HK
dc.identifier.scopusauthoridFedorenko, AL=14828803100en_HK
dc.identifier.scopusauthoridTsintsadze, TSh=6602181172en_HK
dc.identifier.scopusauthoridWright, M=11139776500en_HK
dc.identifier.scopusauthoridTanner, JA=35513993000en_HK
dc.identifier.scopusauthoridMiller, AD=7406230808en_HK
dc.identifier.scopusauthoridLozovaya, NA=6701834046en_HK
dc.identifier.citeulike1053406-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats