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Article: Yin yang 1 directly regulates the transcription of RE-1 silencing transcription factor

TitleYin yang 1 directly regulates the transcription of RE-1 silencing transcription factor
Authors
KeywordsFunctional binding site
Mouse rest promoter
Re-1 silencing transcription factor (rest)
Ying yang 1 (yy1)
Re 1 silencing transcription factor
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34828
Citation
Journal of Neuroscience Research, 2008, v. 86 n. 6, p. 1209-1216 How to Cite?
AbstractThe RE-1 silencing transcription factor (REST) is a master transcription factor that plays a critical role in embryo development, especially during the process of neurogenesis and neural plasticity. However, the mechanism of REST gene transcription regulation is still an open question. Here, by combining bioinformatics analysis and experimental studies, we report that the transcription factor Yin Yang 1 (YY1) bound to a conserved YY1 binding site in the promoter of the mouse REST gene and positively regulated activity of this promoter in SH-SY5Y cells. Furthermore, analysis of microarray data revealed a significant correlation between the expression of YY1 and REST genes. Overall, this study suggests that YY1 directly regulates expression of the REST gene.
Persistent Identifierhttp://hdl.handle.net/10722/124513
ISSN
2015 Impact Factor: 2.689
2015 SCImago Journal Rankings: 1.261

 

DC FieldValueLanguage
dc.contributor.authorJiang, L-
dc.contributor.authorYao, M-
dc.contributor.authorShi, J-
dc.contributor.authorShen, P-
dc.contributor.authorNiu, G-
dc.contributor.authorFei, J-
dc.date.accessioned2010-10-31T10:38:40Z-
dc.date.available2010-10-31T10:38:40Z-
dc.date.issued2008-
dc.identifier.citationJournal of Neuroscience Research, 2008, v. 86 n. 6, p. 1209-1216-
dc.identifier.issn0360-4012-
dc.identifier.urihttp://hdl.handle.net/10722/124513-
dc.description.abstractThe RE-1 silencing transcription factor (REST) is a master transcription factor that plays a critical role in embryo development, especially during the process of neurogenesis and neural plasticity. However, the mechanism of REST gene transcription regulation is still an open question. Here, by combining bioinformatics analysis and experimental studies, we report that the transcription factor Yin Yang 1 (YY1) bound to a conserved YY1 binding site in the promoter of the mouse REST gene and positively regulated activity of this promoter in SH-SY5Y cells. Furthermore, analysis of microarray data revealed a significant correlation between the expression of YY1 and REST genes. Overall, this study suggests that YY1 directly regulates expression of the REST gene.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34828-
dc.relation.ispartofJournal of Neuroscience Research-
dc.rightsJournal of Neuroscience Research. Copyright © John Wiley & Sons, Inc.-
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.subjectFunctional binding site-
dc.subjectMouse rest promoter-
dc.subjectRe-1 silencing transcription factor (rest)-
dc.subjectYing yang 1 (yy1)-
dc.subjectRe 1 silencing transcription factor-
dc.titleYin yang 1 directly regulates the transcription of RE-1 silencing transcription factor-
dc.typeArticle-
dc.identifier.emailNiu, G: wniu@hkucc.hku.hk, gniu@sibs.ac.cn-
dc.identifier.doi10.1002/jnr.21595-
dc.identifier.pmid18092359-
dc.identifier.hkuros180107-
dc.identifier.volume86-
dc.identifier.issue6-
dc.identifier.spage1209-
dc.identifier.epage1216-
dc.publisher.placeUnited States-

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