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Article: Overexpression of AIB1 negatively affects survival of surgically resected non-small-cell lung cancer patients

TitleOverexpression of AIB1 negatively affects survival of surgically resected non-small-cell lung cancer patients
Authors
KeywordsAIB1
Amplification
Immunohistochemistry
Non-small-cell lung carcinoma
Prognosis
Issue Date2010
PublisherOxford University Press. The Journal's web site is located at http://annonc.oxfordjournals.org/
Citation
Annals Of Oncology, 2010, v. 21 n. 8, p. 1675-1681 How to Cite?
AbstractBackground: The amplified in breast cancer 1 (AIB1) gene has been considered to play an oncogenic role in human cancers, but its clinical/prognostic significance in non-small-cell lung cancer (NSCLC) is still unclear. Patients and methods: The methods of immunohistochemistry and FISH were utilized to examine protein expression and amplification of AIB1 in 230 informative surgically resected NSCLCs and in 30 samples of normal lung tissues. Results: Overexpression and amplification of AIB1 were found in 48.3% and 8.2% of NSCLCs, respectively. AIB1 overexpression was associated with AIB1 gene amplification and cell proliferation but not related to estrogen receptor (ER)-α, ER-β, progesterone receptor or androgen receptor status. A positive correlation between AIB1 overexpression and an ascending pathologic node stage in lung adenocarcinoma (ADC) was observed (P = 0.043). Univariate survival analysis demonstrated a significant association of AIB1 overexpression with shortened patient survival, especially for those with stage III disease (P < 0.001). Importantly, AIB1 expression was evaluated as the most significant predictor for survival in multivariate analysis (hazards ratio = 2.069, P < 0.001). Conclusion: Overexpression of AIB1 might provide a selective advantage for lymph node metastasis of lung ADC and serve as a useful biomarker for poor prognosis for NSCLC patients. © The Author 2010. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/124505
ISSN
2015 Impact Factor: 9.269
2015 SCImago Journal Rankings: 4.362
ISI Accession Number ID
Funding AgencyGrant Number
Major State Basic Research Program2006CB910104
2010CB529400
863 Project of China2006AA02A401
2007AA021901
Funding Information:

Major State Basic Research Program (973 project) (2006CB910104, 2010CB529400) and the 863 Project (2006AA02A401, 2007AA021901) of China.

References

 

DC FieldValueLanguage
dc.contributor.authorHe, LRen_HK
dc.contributor.authorZhao, HYen_HK
dc.contributor.authorLi, BKen_HK
dc.contributor.authorZhang, LJen_HK
dc.contributor.authorLiu, MZen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorBian, XWen_HK
dc.contributor.authorZeng, YXen_HK
dc.contributor.authorXie, Den_HK
dc.date.accessioned2010-10-31T10:38:13Z-
dc.date.available2010-10-31T10:38:13Z-
dc.date.issued2010en_HK
dc.identifier.citationAnnals Of Oncology, 2010, v. 21 n. 8, p. 1675-1681en_HK
dc.identifier.issn0923-7534en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124505-
dc.description.abstractBackground: The amplified in breast cancer 1 (AIB1) gene has been considered to play an oncogenic role in human cancers, but its clinical/prognostic significance in non-small-cell lung cancer (NSCLC) is still unclear. Patients and methods: The methods of immunohistochemistry and FISH were utilized to examine protein expression and amplification of AIB1 in 230 informative surgically resected NSCLCs and in 30 samples of normal lung tissues. Results: Overexpression and amplification of AIB1 were found in 48.3% and 8.2% of NSCLCs, respectively. AIB1 overexpression was associated with AIB1 gene amplification and cell proliferation but not related to estrogen receptor (ER)-α, ER-β, progesterone receptor or androgen receptor status. A positive correlation between AIB1 overexpression and an ascending pathologic node stage in lung adenocarcinoma (ADC) was observed (P = 0.043). Univariate survival analysis demonstrated a significant association of AIB1 overexpression with shortened patient survival, especially for those with stage III disease (P < 0.001). Importantly, AIB1 expression was evaluated as the most significant predictor for survival in multivariate analysis (hazards ratio = 2.069, P < 0.001). Conclusion: Overexpression of AIB1 might provide a selective advantage for lymph node metastasis of lung ADC and serve as a useful biomarker for poor prognosis for NSCLC patients. © The Author 2010. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://annonc.oxfordjournals.org/en_HK
dc.relation.ispartofAnnals of Oncologyen_HK
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.subjectAIB1en_HK
dc.subjectAmplificationen_HK
dc.subjectImmunohistochemistryen_HK
dc.subjectNon-small-cell lung carcinomaen_HK
dc.subjectPrognosisen_HK
dc.subject.meshCarcinoma, Non-Small-Cell Lung - genetics - pathology - surgery-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLung Neoplasms - genetics - pathology - surgery-
dc.subject.meshNuclear Receptor Coactivator 3 - genetics-
dc.titleOverexpression of AIB1 negatively affects survival of surgically resected non-small-cell lung cancer patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0923-7534&volume=21&issue=8&spage=1675&epage=1681&date=2010&atitle=Overexpression+of+AIB1+negatively+affects+survival+of+surgically+resected+non-small-cell+lung+cancer+patients-
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/annonc/mdp592en_HK
dc.identifier.pmid20064830-
dc.identifier.scopuseid_2-s2.0-77955255903en_HK
dc.identifier.hkuros175321en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955255903&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1675en_HK
dc.identifier.epage1681en_HK
dc.identifier.isiWOS:000280532000019-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHe, LR=35069492500en_HK
dc.identifier.scopusauthoridZhao, HY=7404778858en_HK
dc.identifier.scopusauthoridLi, BK=26663761000en_HK
dc.identifier.scopusauthoridZhang, LJ=35772164700en_HK
dc.identifier.scopusauthoridLiu, MZ=35285929300en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridBian, XW=7103023096en_HK
dc.identifier.scopusauthoridZeng, YX=7402981579en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK

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