Article: Bauhinia variegata var. variegata trypsin inhibitor: From isolation to potential medicinal applications
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- Publisher Website: 10.1016/j.bbrc.2010.04.140
- Scopus: eid_2-s2.0-77953288202
- PMID: 20435016
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| Title | Bauhinia variegata var. variegata trypsin inhibitor: From isolation to potential medicinal applications | ||||
|---|---|---|---|---|---|
| Authors | Fang, EF3 Wong, JH3 Bah, CSF2 Lin, P3 Tsao, SW1 Ng, TB3 | ||||
| Keywords | Bauhinia variegata var. variegata Cytokines HIV Nasopharyngeal carcinoma Proteinase inhibitors | ||||
| Issue Date | 2010 | ||||
| Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description | ||||
| Citation | Biochemical And Biophysical Research Communications, 2010, v. 396 n. 4, p. 806-811 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.bbrc.2010.04.140 | ||||
| Abstract | Here we report for the first time of a new Kunitz-type trypsin inhibitor (termed BvvTI) from seeds of the Camel's foot tree, Bauhinia variegata var. variegata. BvvTI shares the same reactive site residues (Arg, Ser) and exhibits a homology of N-terminal amino acid sequence to other Bauhinia protease inhibitors. The trypsin inhibitory activity (K i, 0.1 × 10 -9 M) of BvvTI ranks the highest among them. Besides anti-HIV-1 reverse transcriptase activity, BvvTI could significantly inhibit the proliferation of nasopharyngeal cancer CNE-1 cells in a selective way. This may partially be contributed by its induction of cytokines and apoptotic bodies. These results unveil potential medicinal applications of BvvTI. © 2010 Elsevier Inc. All rights reserved. | ||||
| ISSN | 0006-291X 2011 Impact Factor: 2.484 2011 SCImago Journal Rankings: 0.287 | ||||
| DOI | http://dx.doi.org/10.1016/j.bbrc.2010.04.140 | ||||
| ISI Accession Number ID | WOS:000279125100005
Funding Information: We thank Dr. Carol P.Y. Lau, Prof. Lawrence Ramsden and Prof. Richard M.K. Saunders from School of Biological Sciences, the University of Hong Kong, for their kind support of the project. | ||||
| References | References in Scopus |
| dc.contributor.author | Fang, EF | ||||
|---|---|---|---|---|---|
| dc.contributor.author | Wong, JH | ||||
| dc.contributor.author | Bah, CSF | ||||
| dc.contributor.author | Lin, P | ||||
| dc.contributor.author | Tsao, SW | ||||
| dc.contributor.author | Ng, TB | ||||
| dc.date.accessioned | 2010-10-31T10:37:50Z | ||||
| dc.date.available | 2010-10-31T10:37:50Z | ||||
| dc.date.issued | 2010 | ||||
| dc.description.abstract | Here we report for the first time of a new Kunitz-type trypsin inhibitor (termed BvvTI) from seeds of the Camel's foot tree, Bauhinia variegata var. variegata. BvvTI shares the same reactive site residues (Arg, Ser) and exhibits a homology of N-terminal amino acid sequence to other Bauhinia protease inhibitors. The trypsin inhibitory activity (K i, 0.1 × 10 -9 M) of BvvTI ranks the highest among them. Besides anti-HIV-1 reverse transcriptase activity, BvvTI could significantly inhibit the proliferation of nasopharyngeal cancer CNE-1 cells in a selective way. This may partially be contributed by its induction of cytokines and apoptotic bodies. These results unveil potential medicinal applications of BvvTI. © 2010 Elsevier Inc. All rights reserved. | ||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||
| dc.identifier.citation | Biochemical And Biophysical Research Communications, 2010, v. 396 n. 4, p. 806-811 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.bbrc.2010.04.140 | ||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.bbrc.2010.04.140 | ||||
| dc.identifier.epage | 811 | ||||
| dc.identifier.hkuros | 182821 | ||||
| dc.identifier.isi | WOS:000279125100005
Funding Information: We thank Dr. Carol P.Y. Lau, Prof. Lawrence Ramsden and Prof. Richard M.K. Saunders from School of Biological Sciences, the University of Hong Kong, for their kind support of the project. | ||||
| dc.identifier.issn | 0006-291X 2011 Impact Factor: 2.484 2011 SCImago Journal Rankings: 0.287 | ||||
| dc.identifier.issue | 4 | ||||
| dc.identifier.openurl | | ||||
| dc.identifier.pmid | 20435016 | ||||
| dc.identifier.scopus | eid_2-s2.0-77953288202 | ||||
| dc.identifier.spage | 806 | ||||
| dc.identifier.uri | http://hdl.handle.net/10722/124499 | ||||
| dc.identifier.volume | 396 | ||||
| dc.language | eng | ||||
| dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description | ||||
| dc.publisher.place | United States | ||||
| dc.relation.ispartof | Biochemical and Biophysical Research Communications | ||||
| dc.relation.references | References in Scopus | ||||
| dc.subject.mesh | Anti-HIV Agents - chemistry - isolation and purification - pharmacology | ||||
| dc.subject.mesh | Antineoplastic Agents - chemistry - isolation and purification - pharmacology | ||||
| dc.subject.mesh | Bauhinia - metabolism | ||||
| dc.subject.mesh | Peptides - chemistry - isolation and purification - pharmacology | ||||
| dc.subject.mesh | Plant Proteins - chemistry - isolation and purification - pharmacology | ||||
| dc.subject | Bauhinia variegata var. variegata | ||||
| dc.subject | Cytokines | ||||
| dc.subject | HIV | ||||
| dc.subject | Nasopharyngeal carcinoma | ||||
| dc.subject | Proteinase inhibitors | ||||
| dc.title | Bauhinia variegata var. variegata trypsin inhibitor: From isolation to potential medicinal applications | ||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong Li Ka Shing Faculty of Medicine
- University of Otago
- Chinese University of Hong Kong