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Article: Effect of corticosterone and paroxetine on masculine mating behavior: Possible involvement of neurogenesis

TitleEffect of corticosterone and paroxetine on masculine mating behavior: Possible involvement of neurogenesis
Authors
KeywordsCorticosterone
Male Sexual Functioning
Neurogenesis
Olfactory System
Paroxetine
Selective Serotonin Reuptake Inhibitor
Sexual Behavior
SSRI
Issue Date2011
PublisherBlackwell Publishing Ltd. The Journal's website is located at http://www.wiley.com/bw/journal.asp?ref=1743-6095
Citation
Journal of Sexual Medicine, 2011, v. 8 n. 5, p. 1390-1403 How to Cite?
AbstractIntroduction. Corticosterone inhibits male rodent sexual behavior while the mechanism remains obscured. Recent studies have disclosed that neurogenesis in the subventricular zone (SVZ) can be increased by pheromone exposure from the opposite sex, and neurogenesis is essential for normal mating behavior of female mice. Together with the neurogenesis-inhibiting effect of corticosterone, we hypothesize that cell proliferation in the olfactory system is essential for male rodent sexual functioning. Aim. The current study explored the relationship between cell proliferation in the olfactory system and male sexual behavior. Main Outcome Measures. Sexual behavior performance, proliferative cell counts, and c-fos-expressing cell counts. Methods. Adult male rats were treated with corticosterone and/or paroxetine, an antidepressant, for 2 weeks. These two drugs were shown to suppress and enhance hippocampus and SVZ cell proliferation, respectively. Mating behavior was assessed after the treatment, and proliferation of new cells and c-fos-expressing cells, activated neurons in the mating-related regions in the brain, were analyzed. To further confirm the necessity of cell proliferation in mating, inhibition of cell proliferation was performed by intracerebroventricular infusion of cytostatic cytosine arabinose (Ara-c). Results. Corticosterone treatment, which inhibited cell proliferation in both the SVZ and olfactory epithelium, led to inhibited male sexual performance. In contrast, paroxetine increased cell proliferation and improved the performance in corticosterone-treated animals. When cell proliferation in the brain was inhibited by Ara-c, a suppressed sexual performance was found. However, cell proliferation in olfactory epithelium was not inhibited by Ara-c and thus the sexual inhibition is unlikely to be linked to this region. Furthermore, a decrease in c-fos expression in the mating-related regions upon female pheromone stimulation was found. Conclusions. These results suggest that cell proliferation in the SVZ and hippocampus may be involved in the reproduction of the male rodents, and pharmacological treatments may affect sexual functioning through alteration of neurogenesis. © 2010 International Society for Sexual Medicine.
Persistent Identifierhttp://hdl.handle.net/10722/124493
ISSN
2015 Impact Factor: 2.844
2015 SCImago Journal Rankings: 1.306
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong Foundation for Educational Development and Research Limited
National Natural Science Foundation of China30828012
Funding Information:

This study was supported by funding from the Jessie Ho Professorship in Neuroscience (The University of Hong Kong Foundation for Educational Development and Research Limited) and the National Natural Science Foundation of China (#30828012). The authors thank Ms. Sylvia Yan for providing recommendation on the manuscript preparation.

References

 

DC FieldValueLanguage
dc.contributor.authorLau, BWMen_HK
dc.contributor.authorYau, SYen_HK
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorChing, YPen_HK
dc.contributor.authorTang, SWen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-10-31T10:37:29Z-
dc.date.available2010-10-31T10:37:29Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal of Sexual Medicine, 2011, v. 8 n. 5, p. 1390-1403en_HK
dc.identifier.issn1743-6095en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124493-
dc.description.abstractIntroduction. Corticosterone inhibits male rodent sexual behavior while the mechanism remains obscured. Recent studies have disclosed that neurogenesis in the subventricular zone (SVZ) can be increased by pheromone exposure from the opposite sex, and neurogenesis is essential for normal mating behavior of female mice. Together with the neurogenesis-inhibiting effect of corticosterone, we hypothesize that cell proliferation in the olfactory system is essential for male rodent sexual functioning. Aim. The current study explored the relationship between cell proliferation in the olfactory system and male sexual behavior. Main Outcome Measures. Sexual behavior performance, proliferative cell counts, and c-fos-expressing cell counts. Methods. Adult male rats were treated with corticosterone and/or paroxetine, an antidepressant, for 2 weeks. These two drugs were shown to suppress and enhance hippocampus and SVZ cell proliferation, respectively. Mating behavior was assessed after the treatment, and proliferation of new cells and c-fos-expressing cells, activated neurons in the mating-related regions in the brain, were analyzed. To further confirm the necessity of cell proliferation in mating, inhibition of cell proliferation was performed by intracerebroventricular infusion of cytostatic cytosine arabinose (Ara-c). Results. Corticosterone treatment, which inhibited cell proliferation in both the SVZ and olfactory epithelium, led to inhibited male sexual performance. In contrast, paroxetine increased cell proliferation and improved the performance in corticosterone-treated animals. When cell proliferation in the brain was inhibited by Ara-c, a suppressed sexual performance was found. However, cell proliferation in olfactory epithelium was not inhibited by Ara-c and thus the sexual inhibition is unlikely to be linked to this region. Furthermore, a decrease in c-fos expression in the mating-related regions upon female pheromone stimulation was found. Conclusions. These results suggest that cell proliferation in the SVZ and hippocampus may be involved in the reproduction of the male rodents, and pharmacological treatments may affect sexual functioning through alteration of neurogenesis. © 2010 International Society for Sexual Medicine.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's website is located at http://www.wiley.com/bw/journal.asp?ref=1743-6095-
dc.relation.ispartofJournal of Sexual Medicineen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectCorticosteroneen_HK
dc.subjectMale Sexual Functioningen_HK
dc.subjectNeurogenesisen_HK
dc.subjectOlfactory Systemen_HK
dc.subjectParoxetineen_HK
dc.subjectSelective Serotonin Reuptake Inhibitoren_HK
dc.subjectSexual Behavioren_HK
dc.subjectSSRIen_HK
dc.titleEffect of corticosterone and paroxetine on masculine mating behavior: Possible involvement of neurogenesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1743-6095&volume=8&issue=5&spage=1390&epage=1403&date=2010&atitle=Effect+of+corticosterone+and+paroxetine+on+masculline+mating+behavior:+Possible+involvement+of+neurogenesis-
dc.identifier.emailChing, YP:ypching@hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityChing, YP=rp00469en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1743-6109.2010.02081.xen_HK
dc.identifier.pmid20955318-
dc.identifier.scopuseid_2-s2.0-79955162028en_HK
dc.identifier.hkuros180571en_HK
dc.identifier.hkuros186211-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955162028&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1390en_HK
dc.identifier.epage1403en_HK
dc.identifier.isiWOS:000289893400014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLau, BWM=21934562200en_HK
dc.identifier.scopusauthoridYau, SY=24330296200en_HK
dc.identifier.scopusauthoridLee, TMC=36637725800en_HK
dc.identifier.scopusauthoridChing, YP=7005431277en_HK
dc.identifier.scopusauthoridTang, SW=23968420300en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.citeulike9234373-

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