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Article: An amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent

TitleAn amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent
Authors
Poon, CTChan, PSMan, CJiang, FLWong, RNSMak, NKKwong, DWJTsao, SWWong, WK
KeywordsPhotodynamic therapy
Porphyroid
Ru(II)-polypyridyl
Tumor-imaging
Two-photon
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jinorgbio
Citation
Journal Of Inorganic Biochemistry, 2010, v. 104 n. 1, p. 62-70 How to Cite?
DOI: http://dx.doi.org/10.1016/j.jinorgbio.2009.10.004
AbstractAn amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 ± 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/124489
ISSN
0162-0134
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 0.614
ISI Accession Number ID
WOS:000272417300008
Funding AgencyGrant Number
Hong Kong Baptist UniversityFRG/07-08/II-58
Hong Kong ResearchHKBU2023/04P
HKBU 2458/06M
HKBU202308
Funding Information:

The authors thank Prof. K.W. Cheah and Dr. H.L. Tam for their excellent technical support in the two-photon absorption cross-section measurements. This work was financially supported by Hong Kong Baptist University (FRG/07-08/II-58) and three grants from the Hong Kong Research Grants Council (Grant Nos. HKBU2023/04P, HKBU 2458/06M and HKBU202308).

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorPoon, CTen_HK
dc.contributor.authorChan, PSen_HK
dc.contributor.authorMan, Cen_HK
dc.contributor.authorJiang, FLen_HK
dc.contributor.authorWong, RNSen_HK
dc.contributor.authorMak, NKen_HK
dc.contributor.authorKwong, DWJen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorWong, WKen_HK
dc.date.accessioned2010-10-31T10:37:16Z-
dc.date.available2010-10-31T10:37:16Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Inorganic Biochemistry, 2010, v. 104 n. 1, p. 62-70en_HK
dc.identifier.issn0162-0134en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124489-
dc.description.abstractAn amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 ± 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jinorgbioen_HK
dc.relation.ispartofJournal of Inorganic Biochemistryen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Journal of Inorganic Biochemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, VOL 104, ISSUE 1, (2010) DOI 10.1016/j.jinorgbio.2009.10.004-
dc.subjectPhotodynamic therapyen_HK
dc.subjectPorphyroiden_HK
dc.subjectRu(II)-polypyridylen_HK
dc.subjectTumor-imagingen_HK
dc.subjectTwo-photonen_HK
dc.subject.meshPorphyroid-
dc.subject.meshTwo-photon-
dc.subject.meshTumor-imaging-
dc.subject.meshPhotodynamic therapy-
dc.subject.meshRu(II)–polypyridyl-
dc.titleAn amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0162-0134&volume=104&issue=1&spage=62&epage=70&date=2010&atitle=An+amphiphilic+ruthenium(II)-polypyridyl+appended+porphyrin+as+potential+bifunctional+two-photon+tumor-imaging+and+photodynamic+therapeutic+agenten_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jinorgbio.2009.10.004en_HK
dc.identifier.pmid19880187-
dc.identifier.scopuseid_2-s2.0-70449678441en_HK
dc.identifier.hkuros182720en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70449678441&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume104en_HK
dc.identifier.issue1en_HK
dc.identifier.spage62en_HK
dc.identifier.epage70en_HK
dc.identifier.isiWOS:000272417300008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPoon, CT=23467574000en_HK
dc.identifier.scopusauthoridChan, PS=35075787200en_HK
dc.identifier.scopusauthoridMan, C=7005722377en_HK
dc.identifier.scopusauthoridJiang, FL=7202977415en_HK
dc.identifier.scopusauthoridWong, RNS=7402126957en_HK
dc.identifier.scopusauthoridMak, NK=35582657000en_HK
dc.identifier.scopusauthoridKwong, DWJ=7102731477en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridWong, WK=7403972869en_HK
dc.identifier.citeulike5923210-
dc.identifier.issnl0162-0134-

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