Article: Apatite-formation ability - Predictor of "bioactivity"?
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- Publisher Website: 10.1016/j.actbio.2010.05.013
- Scopus: eid_2-s2.0-77956929374
- PMID: 20493974
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| Title | Apatite-formation ability - Predictor of "bioactivity"? |
|---|---|
| Authors | Pan, H1 Zhao, X1 Darvell, BW2 Lu, WW1 |
| Keywords | Apatite formation Bioactivity Biocompatibility Biomaterials Degradation |
| Issue Date | 2010 |
| Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat |
| Citation | Acta Biomaterialia, 2010, v. 6 n. 11, p. 4181-4188 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.actbio.2010.05.013 |
| Abstract | The ability to trigger the formation of apatite from a supersaturated solution has been widely used to imply the bioactivity of an implant in vivo. However, the method itself may provide at best incomplete information, primarily because it is determined only by solution supersaturation, irrespective of biological processes. Bone regeneration is triggered mainly by the vitality of osteoblasts, and regulated by the expression of growth factors such as oestrogen, parathyroid hormone and bone morphogenetic proteins, while ions or other species released from an implant may affect the expression of such growth factors, and so bone resorption or formation. The misinterpretation of the outcome of such tests must result in misunderstanding of the true effects and behaviour of materials intended for use in embedded biological contexts. Thus, the underlying and motivating hypothesis needs to be carefully reconsidered, along with the results of all work founded on the concept. It would seem that it is only viable to test using osteoblasts, whether in vivo or in vitro. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| ISSN | 1742-7061 2011 Impact Factor: 4.865 2011 SCImago Journal Rankings: 0.285 |
| DOI | http://dx.doi.org/10.1016/j.actbio.2010.05.013 |
| References | References in Scopus |
| Grants | Optimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications |
| dc.contributor.author | Pan, H | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Zhao, X | ||||||
| dc.contributor.author | Darvell, BW | ||||||
| dc.contributor.author | Lu, WW | ||||||
| dc.date.accessioned | 2010-10-31T10:35:17Z | ||||||
| dc.date.available | 2010-10-31T10:35:17Z | ||||||
| dc.date.issued | 2010 | ||||||
| dc.description.abstract | The ability to trigger the formation of apatite from a supersaturated solution has been widely used to imply the bioactivity of an implant in vivo. However, the method itself may provide at best incomplete information, primarily because it is determined only by solution supersaturation, irrespective of biological processes. Bone regeneration is triggered mainly by the vitality of osteoblasts, and regulated by the expression of growth factors such as oestrogen, parathyroid hormone and bone morphogenetic proteins, while ions or other species released from an implant may affect the expression of such growth factors, and so bone resorption or formation. The misinterpretation of the outcome of such tests must result in misunderstanding of the true effects and behaviour of materials intended for use in embedded biological contexts. Thus, the underlying and motivating hypothesis needs to be carefully reconsidered, along with the results of all work founded on the concept. It would seem that it is only viable to test using osteoblasts, whether in vivo or in vitro. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | ||||||
| dc.description.grant | Optimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications | ||||||
| dc.description.grantcode | 96197 | ||||||
| dc.description.nature | link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Acta Biomaterialia, 2010, v. 6 n. 11, p. 4181-4188 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.actbio.2010.05.013 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.actbio.2010.05.013 | ||||||
| dc.identifier.epage | 4188 | ||||||
| dc.identifier.hkuros | 181358 | ||||||
| dc.identifier.isi | WOS:000282921500001
Funding Information: This study was supported by Hong Kong ITF GHP/009/06 and HKRGC (HKU7147/07E). The authors thank Frankie Chan for his assistance in SEM analysis and Guofeng Chen for XRD analysis. We also thank Xin Zhang, Deping Wang, Wenhai Huang (TongJi University, Shanghai, China), Kaili Lin and Jiang Chang (Shanghai Institute of Ceramics, Shanghai, China) for the materials illustrated. | ||||||
| dc.identifier.issn | 1742-7061 2011 Impact Factor: 4.865 2011 SCImago Journal Rankings: 0.285 | ||||||
| dc.identifier.issue | 11 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 20493974 | ||||||
| dc.identifier.scopus | eid_2-s2.0-77956929374 | ||||||
| dc.identifier.spage | 4181 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/124455 | ||||||
| dc.identifier.volume | 6 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat | ||||||
| dc.publisher.place | Netherlands | ||||||
| dc.relation.ispartof | Acta Biomaterialia | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject | Apatite formation | ||||||
| dc.subject | Bioactivity | ||||||
| dc.subject | Biocompatibility | ||||||
| dc.subject | Biomaterials | ||||||
| dc.subject | Degradation | ||||||
| dc.title | Apatite-formation ability - Predictor of "bioactivity"? | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- Health Sciences Centre