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Article: Apatite-formation ability - Predictor of "bioactivity"?

TitleApatite-formation ability - Predictor of "bioactivity"?
Authors
KeywordsApatite formation
Bioactivity
Biocompatibility
Biomaterials
Degradation
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
Citation
Acta Biomaterialia, 2010, v. 6 n. 11, p. 4181-4188 How to Cite?
AbstractThe ability to trigger the formation of apatite from a supersaturated solution has been widely used to imply the bioactivity of an implant in vivo. However, the method itself may provide at best incomplete information, primarily because it is determined only by solution supersaturation, irrespective of biological processes. Bone regeneration is triggered mainly by the vitality of osteoblasts, and regulated by the expression of growth factors such as oestrogen, parathyroid hormone and bone morphogenetic proteins, while ions or other species released from an implant may affect the expression of such growth factors, and so bone resorption or formation. The misinterpretation of the outcome of such tests must result in misunderstanding of the true effects and behaviour of materials intended for use in embedded biological contexts. Thus, the underlying and motivating hypothesis needs to be carefully reconsidered, along with the results of all work founded on the concept. It would seem that it is only viable to test using osteoblasts, whether in vivo or in vitro. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/124455
ISSN
2014 Impact Factor: 6.025
2014 SCImago Journal Rankings: 1.643
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong ITFGHP/009/06
HKRGCHKU7147/07E
Funding Information:

This study was supported by Hong Kong ITF GHP/009/06 and HKRGC (HKU7147/07E). The authors thank Frankie Chan for his assistance in SEM analysis and Guofeng Chen for XRD analysis. We also thank Xin Zhang, Deping Wang, Wenhai Huang (TongJi University, Shanghai, China), Kaili Lin and Jiang Chang (Shanghai Institute of Ceramics, Shanghai, China) for the materials illustrated.

References
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DC FieldValueLanguage
dc.contributor.authorPan, Hen_HK
dc.contributor.authorZhao, Xen_HK
dc.contributor.authorDarvell, BWen_HK
dc.contributor.authorLu, WWen_HK
dc.date.accessioned2010-10-31T10:35:17Z-
dc.date.available2010-10-31T10:35:17Z-
dc.date.issued2010en_HK
dc.identifier.citationActa Biomaterialia, 2010, v. 6 n. 11, p. 4181-4188en_HK
dc.identifier.issn1742-7061en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124455-
dc.description.abstractThe ability to trigger the formation of apatite from a supersaturated solution has been widely used to imply the bioactivity of an implant in vivo. However, the method itself may provide at best incomplete information, primarily because it is determined only by solution supersaturation, irrespective of biological processes. Bone regeneration is triggered mainly by the vitality of osteoblasts, and regulated by the expression of growth factors such as oestrogen, parathyroid hormone and bone morphogenetic proteins, while ions or other species released from an implant may affect the expression of such growth factors, and so bone resorption or formation. The misinterpretation of the outcome of such tests must result in misunderstanding of the true effects and behaviour of materials intended for use in embedded biological contexts. Thus, the underlying and motivating hypothesis needs to be carefully reconsidered, along with the results of all work founded on the concept. It would seem that it is only viable to test using osteoblasts, whether in vivo or in vitro. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomaten_HK
dc.relation.ispartofActa Biomaterialiaen_HK
dc.subjectApatite formationen_HK
dc.subjectBioactivityen_HK
dc.subjectBiocompatibilityen_HK
dc.subjectBiomaterialsen_HK
dc.subjectDegradationen_HK
dc.titleApatite-formation ability - Predictor of "bioactivity"?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1742-7061&volume=6&issue=11&spage=4181&epage=4188&date=2010&atitle=Apatite-formation+ability+-+predictor+of+%27bioactivity%27en_HK
dc.identifier.emailPan, H: haobo@hku.hken_HK
dc.identifier.emailDarvell, BW: b.w.darvell@hku.hken_HK
dc.identifier.emailLu, WW: wwlu@hku.hken_HK
dc.identifier.authorityPan, H=rp01564en_HK
dc.identifier.authorityDarvell, BW=rp00007en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.actbio.2010.05.013en_HK
dc.identifier.pmid20493974-
dc.identifier.scopuseid_2-s2.0-77956929374en_HK
dc.identifier.hkuros181358en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956929374&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue11en_HK
dc.identifier.spage4181en_HK
dc.identifier.epage4188en_HK
dc.identifier.eissn1878-7568-
dc.identifier.isiWOS:000282921500001-
dc.publisher.placeNetherlandsen_HK
dc.relation.projectOptimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications-
dc.identifier.scopusauthoridPan, H=7403295092en_HK
dc.identifier.scopusauthoridZhao, X=8599534100en_HK
dc.identifier.scopusauthoridDarvell, BW=7005953926en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK

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