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Article: Apatite-formation ability - Predictor of "bioactivity"?
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TitleApatite-formation ability - Predictor of "bioactivity"?
 
AuthorsPan, H1
Zhao, X1
Darvell, BW2
Lu, WW1
 
KeywordsApatite formation
Bioactivity
Biocompatibility
Biomaterials
Degradation
 
Issue Date2010
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
 
CitationActa Biomaterialia, 2010, v. 6 n. 11, p. 4181-4188 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.actbio.2010.05.013
 
AbstractThe ability to trigger the formation of apatite from a supersaturated solution has been widely used to imply the bioactivity of an implant in vivo. However, the method itself may provide at best incomplete information, primarily because it is determined only by solution supersaturation, irrespective of biological processes. Bone regeneration is triggered mainly by the vitality of osteoblasts, and regulated by the expression of growth factors such as oestrogen, parathyroid hormone and bone morphogenetic proteins, while ions or other species released from an implant may affect the expression of such growth factors, and so bone resorption or formation. The misinterpretation of the outcome of such tests must result in misunderstanding of the true effects and behaviour of materials intended for use in embedded biological contexts. Thus, the underlying and motivating hypothesis needs to be carefully reconsidered, along with the results of all work founded on the concept. It would seem that it is only viable to test using osteoblasts, whether in vivo or in vitro. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
 
ISSN1742-7061
2012 Impact Factor: 5.093
2012 SCImago Journal Rankings: 1.614
 
DOIhttp://dx.doi.org/10.1016/j.actbio.2010.05.013
 
ISI Accession Number IDWOS:000282921500001
Funding AgencyGrant Number
Hong Kong ITFGHP/009/06
HKRGCHKU7147/07E
Funding Information:

This study was supported by Hong Kong ITF GHP/009/06 and HKRGC (HKU7147/07E). The authors thank Frankie Chan for his assistance in SEM analysis and Guofeng Chen for XRD analysis. We also thank Xin Zhang, Deping Wang, Wenhai Huang (TongJi University, Shanghai, China), Kaili Lin and Jiang Chang (Shanghai Institute of Ceramics, Shanghai, China) for the materials illustrated.

 
ReferencesReferences in Scopus
 
GrantsOptimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications
 
DC FieldValue
dc.contributor.authorPan, H
 
dc.contributor.authorZhao, X
 
dc.contributor.authorDarvell, BW
 
dc.contributor.authorLu, WW
 
dc.date.accessioned2010-10-31T10:35:17Z
 
dc.date.available2010-10-31T10:35:17Z
 
dc.date.issued2010
 
dc.description.abstractThe ability to trigger the formation of apatite from a supersaturated solution has been widely used to imply the bioactivity of an implant in vivo. However, the method itself may provide at best incomplete information, primarily because it is determined only by solution supersaturation, irrespective of biological processes. Bone regeneration is triggered mainly by the vitality of osteoblasts, and regulated by the expression of growth factors such as oestrogen, parathyroid hormone and bone morphogenetic proteins, while ions or other species released from an implant may affect the expression of such growth factors, and so bone resorption or formation. The misinterpretation of the outcome of such tests must result in misunderstanding of the true effects and behaviour of materials intended for use in embedded biological contexts. Thus, the underlying and motivating hypothesis needs to be carefully reconsidered, along with the results of all work founded on the concept. It would seem that it is only viable to test using osteoblasts, whether in vivo or in vitro. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationActa Biomaterialia, 2010, v. 6 n. 11, p. 4181-4188 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.actbio.2010.05.013
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.actbio.2010.05.013
 
dc.identifier.eissn1878-7568
 
dc.identifier.epage4188
 
dc.identifier.hkuros181358
 
dc.identifier.isiWOS:000282921500001
Funding AgencyGrant Number
Hong Kong ITFGHP/009/06
HKRGCHKU7147/07E
Funding Information:

This study was supported by Hong Kong ITF GHP/009/06 and HKRGC (HKU7147/07E). The authors thank Frankie Chan for his assistance in SEM analysis and Guofeng Chen for XRD analysis. We also thank Xin Zhang, Deping Wang, Wenhai Huang (TongJi University, Shanghai, China), Kaili Lin and Jiang Chang (Shanghai Institute of Ceramics, Shanghai, China) for the materials illustrated.

 
dc.identifier.issn1742-7061
2012 Impact Factor: 5.093
2012 SCImago Journal Rankings: 1.614
 
dc.identifier.issue11
 
dc.identifier.openurl
 
dc.identifier.pmid20493974
 
dc.identifier.scopuseid_2-s2.0-77956929374
 
dc.identifier.spage4181
 
dc.identifier.urihttp://hdl.handle.net/10722/124455
 
dc.identifier.volume6
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofActa Biomaterialia
 
dc.relation.projectOptimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications
 
dc.relation.referencesReferences in Scopus
 
dc.subjectApatite formation
 
dc.subjectBioactivity
 
dc.subjectBiocompatibility
 
dc.subjectBiomaterials
 
dc.subjectDegradation
 
dc.titleApatite-formation ability - Predictor of "bioactivity"?
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Health Sciences Centre