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Article: Failure of a glass ionomer to remineralize apatite-depleted dentin

TitleFailure of a glass ionomer to remineralize apatite-depleted dentin
Authors
KeywordsApatite
Demineralized dentin
Glass-ionomer cement
Ion diffusion.
Remineralization
Issue Date2010
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2010, v. 89 n. 3, p. 230-235 How to Cite?
AbstractRemineralization of demineralized dentin lesions adjacent to glass-ionomer cements (GICs) has been reported in the literature. This study tested the hypothesis that a strontium-based GIC can remineralize completely demineralized dentin by nucleation of new apatite crystallites within an apatite-free dentin matrix. Human dentin specimens were acid-etched, bonded with Fuji IX GP, and immersed in a calcium-and-phosphate-containing 1.5X simulated body fluid (SBF) for 1-4 months. Polyacrylic acid and polyvinylphosphonic acid biomimetic analogs were added to the SBFs to create 2 additional remineralization media. Specimens were processed by transmission electron microscopy (TEM). No apatite deposition could be identified in the completely demineralized dentin in any of the specimens immersed in the 3 remineralization media, despite TEM/EDX evidence of diffusion of ions specific to the strontium-based GIC into the demineralized dentin. The hypothesis was rejected; mineral concentration alone is not a sufficient endpoint for assessing the success of contemporary remineralization strategies.
Persistent Identifierhttp://hdl.handle.net/10722/124452
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institute of Dental and Craniofacial ResearchR21 DE019213-01
Funding Information:

The Fuji IX<INF>GP</INF> capsule kits were generous gifts from GC America, Inc. This study was supported by Grant R21 DE019213-01 from the National Institute of Dental and Craniofacial Research (PI. F. R. Tay). We thank Bob Smith for TEM technical assistance and Michelle Barnes for secretarial support.

References

 

DC FieldValueLanguage
dc.contributor.authorKim, YKen_HK
dc.contributor.authorYiu, CKYen_HK
dc.contributor.authorKim, JRen_HK
dc.contributor.authorGu, Len_HK
dc.contributor.authorKim, SKen_HK
dc.contributor.authorWeller, RNen_HK
dc.contributor.authorPashley, DHen_HK
dc.contributor.authorTay, FRen_HK
dc.date.accessioned2010-10-31T10:35:07Z-
dc.date.available2010-10-31T10:35:07Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Dental Research, 2010, v. 89 n. 3, p. 230-235en_HK
dc.identifier.issn0022-0345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124452-
dc.description.abstractRemineralization of demineralized dentin lesions adjacent to glass-ionomer cements (GICs) has been reported in the literature. This study tested the hypothesis that a strontium-based GIC can remineralize completely demineralized dentin by nucleation of new apatite crystallites within an apatite-free dentin matrix. Human dentin specimens were acid-etched, bonded with Fuji IX GP, and immersed in a calcium-and-phosphate-containing 1.5X simulated body fluid (SBF) for 1-4 months. Polyacrylic acid and polyvinylphosphonic acid biomimetic analogs were added to the SBFs to create 2 additional remineralization media. Specimens were processed by transmission electron microscopy (TEM). No apatite deposition could be identified in the completely demineralized dentin in any of the specimens immersed in the 3 remineralization media, despite TEM/EDX evidence of diffusion of ions specific to the strontium-based GIC into the demineralized dentin. The hypothesis was rejected; mineral concentration alone is not a sufficient endpoint for assessing the success of contemporary remineralization strategies.en_HK
dc.languageengen_HK
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_HK
dc.relation.ispartofJournal of Dental Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectApatiteen_HK
dc.subjectDemineralized dentinen_HK
dc.subjectGlass-ionomer cementen_HK
dc.subjectIon diffusion.en_HK
dc.subjectRemineralizationen_HK
dc.subject.meshDental Restoration, Permanent - methods-
dc.subject.meshDentin - drug effects-
dc.subject.meshGlass Ionomer Cements - chemistry - therapeutic use-
dc.subject.meshTooth Demineralization - therapy-
dc.subject.meshTooth Remineralization - methods-
dc.titleFailure of a glass ionomer to remineralize apatite-depleted dentinen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0345&volume=89&issue=3&spage=230&epage=235&date=2010&atitle=Failure+of+a+glass+lonomer+to+remineralize+aapatite-depleted+dentinen_HK
dc.identifier.emailYiu, CKY:ckyyiu@hkucc.hku.hken_HK
dc.identifier.authorityYiu, CKY=rp00018en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1177/0022034509357172en_HK
dc.identifier.pmid20110510-
dc.identifier.pmcidPMC2826886-
dc.identifier.scopuseid_2-s2.0-77749304060en_HK
dc.identifier.hkuros174817en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77749304060&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume89en_HK
dc.identifier.issue3en_HK
dc.identifier.spage230en_HK
dc.identifier.epage235en_HK
dc.identifier.eissn1544-0591-
dc.identifier.isiWOS:000274431100003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKim, YK=35317609200en_HK
dc.identifier.scopusauthoridYiu, CKY=7007115156en_HK
dc.identifier.scopusauthoridKim, JR=23477724500en_HK
dc.identifier.scopusauthoridGu, L=26425065400en_HK
dc.identifier.scopusauthoridKim, SK=34770864400en_HK
dc.identifier.scopusauthoridWeller, RN=7201400663en_HK
dc.identifier.scopusauthoridPashley, DH=35448600800en_HK
dc.identifier.scopusauthoridTay, FR=7102091962en_HK

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