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Article: In vitro remineralization of severely compromised bonded dentin
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TitleIn vitro remineralization of severely compromised bonded dentin
 
AuthorsMai, S3
Kim, YK2
Kim, J4
Yiu, CKY1
Ling, J3
Pashley, DH5
Tay, FR5
 
KeywordsBiomimetic analogs
Hypermineralized dentin.
Intrafibrillar remineralization
Remineralization
Structurally altered collagen
 
Issue Date2010
 
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
 
CitationJournal Of Dental Research, 2010, v. 89 n. 4, p. 405-410 [How to Cite?]
DOI: http://dx.doi.org/10.1177/0022034510363662
 
AbstractBiomimetic remineralization is potentially useful for the remineralization of incompletely resin-infiltrated collagen matrices created by etch-and-rinse adhesives. In this study, we tested the hypothesis that structurally altered dentin collagen cannot be remineralized to the same hierarchical order and dimension seen in structurally intact dentin collagen. The remineralization medium consisted of a set Portland cement/simulated body fluid system containing polycarboxylic acid and polyvinylphosphonic acid as biomimetic analogs. Remineralization of air-dried, collapsed hybrid layers was apparent after one month, with hybrid layers remineralized to 80-90% of their thickness after 2-4 months. A hypermineralized layer was seen on the hybrid layer surface, and tubular orifices were occluded with apatite deposits that resembled those present in non-carious cervical dentin. Structurally altered collagen is unlikely to be remineralized to the same hierarchical order and dimension as seen in intact dentin. The aggressively air-dried acid-etched dentin remineralization model also sheds light on the mechanism of sclerotic dentin formation.
 
ISSN0022-0345
2013 Impact Factor: 4.144
2013 SCImago Journal Rankings: 1.492
 
DOIhttp://dx.doi.org/10.1177/0022034510363662
 
PubMed Central IDPMC2840178
 
ISI Accession Number IDWOS:000275566800015
Funding AgencyGrant Number
National Institute of Dental and Craniofacial ResearchR21 D019213-01
Funding Information:

This study was supported by Grant R21 D019213-01 from the National Institute of Dental and Craniofacial Research (PI. Franklin R. Tay). We thank Michelle Barnes for secretarial support.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorMai, S
 
dc.contributor.authorKim, YK
 
dc.contributor.authorKim, J
 
dc.contributor.authorYiu, CKY
 
dc.contributor.authorLing, J
 
dc.contributor.authorPashley, DH
 
dc.contributor.authorTay, FR
 
dc.date.accessioned2010-10-31T10:34:42Z
 
dc.date.available2010-10-31T10:34:42Z
 
dc.date.issued2010
 
dc.description.abstractBiomimetic remineralization is potentially useful for the remineralization of incompletely resin-infiltrated collagen matrices created by etch-and-rinse adhesives. In this study, we tested the hypothesis that structurally altered dentin collagen cannot be remineralized to the same hierarchical order and dimension seen in structurally intact dentin collagen. The remineralization medium consisted of a set Portland cement/simulated body fluid system containing polycarboxylic acid and polyvinylphosphonic acid as biomimetic analogs. Remineralization of air-dried, collapsed hybrid layers was apparent after one month, with hybrid layers remineralized to 80-90% of their thickness after 2-4 months. A hypermineralized layer was seen on the hybrid layer surface, and tubular orifices were occluded with apatite deposits that resembled those present in non-carious cervical dentin. Structurally altered collagen is unlikely to be remineralized to the same hierarchical order and dimension as seen in intact dentin. The aggressively air-dried acid-etched dentin remineralization model also sheds light on the mechanism of sclerotic dentin formation.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Dental Research, 2010, v. 89 n. 4, p. 405-410 [How to Cite?]
DOI: http://dx.doi.org/10.1177/0022034510363662
 
dc.identifier.doihttp://dx.doi.org/10.1177/0022034510363662
 
dc.identifier.epage410
 
dc.identifier.hkuros174820
 
dc.identifier.isiWOS:000275566800015
Funding AgencyGrant Number
National Institute of Dental and Craniofacial ResearchR21 D019213-01
Funding Information:

This study was supported by Grant R21 D019213-01 from the National Institute of Dental and Craniofacial Research (PI. Franklin R. Tay). We thank Michelle Barnes for secretarial support.

 
dc.identifier.issn0022-0345
2013 Impact Factor: 4.144
2013 SCImago Journal Rankings: 1.492
 
dc.identifier.issue4
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC2840178
 
dc.identifier.pmid20173183
 
dc.identifier.scopuseid_2-s2.0-77949646396
 
dc.identifier.spage405
 
dc.identifier.urihttp://hdl.handle.net/10722/124444
 
dc.identifier.volume89
 
dc.languageeng
 
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Dental Research
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Dental Research. Copyright © Sage Publications, Inc..
 
dc.subject.meshAcid Etching, Dental - adverse effects
 
dc.subject.meshBiomimetic Materials - therapeutic use
 
dc.subject.meshDental Bonding - adverse effects
 
dc.subject.meshDentin - drug effects - pathology
 
dc.subject.meshTooth Remineralization - methods
 
dc.subjectBiomimetic analogs
 
dc.subjectHypermineralized dentin.
 
dc.subjectIntrafibrillar remineralization
 
dc.subjectRemineralization
 
dc.subjectStructurally altered collagen
 
dc.titleIn vitro remineralization of severely compromised bonded dentin
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Kyungpook National University
  3. Sun Yat-Sen University
  4. Kyung Hee University
  5. Medical College of Georgia