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Article: In vitro remineralization of severely compromised bonded dentin

TitleIn vitro remineralization of severely compromised bonded dentin
Authors
KeywordsBiomimetic analogs
Hypermineralized dentin.
Intrafibrillar remineralization
Remineralization
Structurally altered collagen
Issue Date2010
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2010, v. 89 n. 4, p. 405-410 How to Cite?
AbstractBiomimetic remineralization is potentially useful for the remineralization of incompletely resin-infiltrated collagen matrices created by etch-and-rinse adhesives. In this study, we tested the hypothesis that structurally altered dentin collagen cannot be remineralized to the same hierarchical order and dimension seen in structurally intact dentin collagen. The remineralization medium consisted of a set Portland cement/simulated body fluid system containing polycarboxylic acid and polyvinylphosphonic acid as biomimetic analogs. Remineralization of air-dried, collapsed hybrid layers was apparent after one month, with hybrid layers remineralized to 80-90% of their thickness after 2-4 months. A hypermineralized layer was seen on the hybrid layer surface, and tubular orifices were occluded with apatite deposits that resembled those present in non-carious cervical dentin. Structurally altered collagen is unlikely to be remineralized to the same hierarchical order and dimension as seen in intact dentin. The aggressively air-dried acid-etched dentin remineralization model also sheds light on the mechanism of sclerotic dentin formation.
Persistent Identifierhttp://hdl.handle.net/10722/124444
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institute of Dental and Craniofacial ResearchR21 D019213-01
Funding Information:

This study was supported by Grant R21 D019213-01 from the National Institute of Dental and Craniofacial Research (PI. Franklin R. Tay). We thank Michelle Barnes for secretarial support.

References

 

DC FieldValueLanguage
dc.contributor.authorMai, Sen_HK
dc.contributor.authorKim, YKen_HK
dc.contributor.authorKim, Jen_HK
dc.contributor.authorYiu, CKYen_HK
dc.contributor.authorLing, Jen_HK
dc.contributor.authorPashley, DHen_HK
dc.contributor.authorTay, FRen_HK
dc.date.accessioned2010-10-31T10:34:42Z-
dc.date.available2010-10-31T10:34:42Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Dental Research, 2010, v. 89 n. 4, p. 405-410en_HK
dc.identifier.issn0022-0345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124444-
dc.description.abstractBiomimetic remineralization is potentially useful for the remineralization of incompletely resin-infiltrated collagen matrices created by etch-and-rinse adhesives. In this study, we tested the hypothesis that structurally altered dentin collagen cannot be remineralized to the same hierarchical order and dimension seen in structurally intact dentin collagen. The remineralization medium consisted of a set Portland cement/simulated body fluid system containing polycarboxylic acid and polyvinylphosphonic acid as biomimetic analogs. Remineralization of air-dried, collapsed hybrid layers was apparent after one month, with hybrid layers remineralized to 80-90% of their thickness after 2-4 months. A hypermineralized layer was seen on the hybrid layer surface, and tubular orifices were occluded with apatite deposits that resembled those present in non-carious cervical dentin. Structurally altered collagen is unlikely to be remineralized to the same hierarchical order and dimension as seen in intact dentin. The aggressively air-dried acid-etched dentin remineralization model also sheds light on the mechanism of sclerotic dentin formation.en_HK
dc.languageengen_HK
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_HK
dc.relation.ispartofJournal of Dental Researchen_HK
dc.rightsJournal of Dental Research. Copyright © Sage Publications, Inc..-
dc.subjectBiomimetic analogsen_HK
dc.subjectHypermineralized dentin.en_HK
dc.subjectIntrafibrillar remineralizationen_HK
dc.subjectRemineralizationen_HK
dc.subjectStructurally altered collagenen_HK
dc.subject.meshAcid Etching, Dental - adverse effects-
dc.subject.meshBiomimetic Materials - therapeutic use-
dc.subject.meshDental Bonding - adverse effects-
dc.subject.meshDentin - drug effects - pathology-
dc.subject.meshTooth Remineralization - methods-
dc.titleIn vitro remineralization of severely compromised bonded dentinen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0345&volume=89&issue=4&spage=405&epage=410&date=2010&atitle=In+vitro+remineralization+of+severely+compromised+bonded+dentinen_HK
dc.identifier.emailYiu, CKY:ckyyiu@hkucc.hku.hken_HK
dc.identifier.authorityYiu, CKY=rp00018en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/0022034510363662en_HK
dc.identifier.pmid20173183-
dc.identifier.pmcidPMC2840178-
dc.identifier.scopuseid_2-s2.0-77949646396en_HK
dc.identifier.hkuros174820en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949646396&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume89en_HK
dc.identifier.issue4en_HK
dc.identifier.spage405en_HK
dc.identifier.epage410en_HK
dc.identifier.isiWOS:000275566800015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMai, S=8553591000en_HK
dc.identifier.scopusauthoridKim, YK=35317609200en_HK
dc.identifier.scopusauthoridKim, J=34769867600en_HK
dc.identifier.scopusauthoridYiu, CKY=7007115156en_HK
dc.identifier.scopusauthoridLing, J=7201776422en_HK
dc.identifier.scopusauthoridPashley, DH=35448600800en_HK
dc.identifier.scopusauthoridTay, FR=7102091962en_HK

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