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Article: One-year outcomes of repeated adjunctive photodynamic therapy during periodontal maintenance: A proof-of-principle randomized-controlled clinical trial

TitleOne-year outcomes of repeated adjunctive photodynamic therapy during periodontal maintenance: A proof-of-principle randomized-controlled clinical trial
Authors
KeywordsClinical outcomes
PDT
Periodontal maintenance
Photodynamic therapy
Probing depth
RCT
Supportive periodontal therapy
Issue Date2009
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 2009, v. 36 n. 8, p. 661-666 How to Cite?
AbstractBackground: Single photodynamic therapy (PDT) has been effective in initial periodontal therapy, but only improved bleeding on probing (BoP) in maintenance patients after a single use. Repeated PDT has not been addressed. Objectives: To study the possible added benefits of repeated adjunctive PDT to conventional treatment of residual pockets in patients enrolled in periodontal maintenance. Material and Methods: Ten maintenance patients with 70 residual pockets [probing pocket depth (PPD)≥5 mm] were randomly assigned for treatment five times in 2 weeks (Days 0, 1, 2, 7, 14) with PDT (test) or non-activated laser (control) following debridement. The primary outcome variable was PPD, and the secondary variables were clinical attachment level (CAL) and BoP. These were assessed at 3, 6 and 12 months following the interventions. Results: Greater PPD reductions were observed in the test (-0.67 ± 0.34; p=0.01) compared with the control patients (-0.04 ± 0.33; NS) after 6 months. Significant CAL gain (+0.52 ± 0.31; p=0.01) was noted for the test, but not in the control (-0.27 ± 0.52; NS) patients after 6 months. BoP percentages dcreased significantly in test (97-64%, 67%, 77%), but not control patients after 3, 6 and 12 months. Conclusions: Repeated (five times) PDT adjunctive to debridement yielded improved clinical outcomes in residual pockets in maintenance patients. The effects were best documented after 6 months. © 2009 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/124432
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
Funding AgencyGrant Number
HELBOs Photodynamic Systems GmbH, Grieskirchen, Austria
Clinical Research Foundation (CRF)
Funding Information:

This study was in part supported by HELBOs Photodynamic Systems GmbH, Grieskirchen, Austria, and by the Clinical Research Foundation (CRF) for the Promotion of Oral Health, Brienz BE, Switzerland.

References

 

DC FieldValueLanguage
dc.contributor.authorLulic, Men_HK
dc.contributor.authorLeiggener Görög, Ien_HK
dc.contributor.authorSalvi, GEen_HK
dc.contributor.authorRamseier, CAen_HK
dc.contributor.authorMattheos, Nen_HK
dc.contributor.authorLang, NPen_HK
dc.date.accessioned2010-10-31T10:34:03Z-
dc.date.available2010-10-31T10:34:03Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Clinical Periodontology, 2009, v. 36 n. 8, p. 661-666en_HK
dc.identifier.issn0303-6979en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124432-
dc.description.abstractBackground: Single photodynamic therapy (PDT) has been effective in initial periodontal therapy, but only improved bleeding on probing (BoP) in maintenance patients after a single use. Repeated PDT has not been addressed. Objectives: To study the possible added benefits of repeated adjunctive PDT to conventional treatment of residual pockets in patients enrolled in periodontal maintenance. Material and Methods: Ten maintenance patients with 70 residual pockets [probing pocket depth (PPD)≥5 mm] were randomly assigned for treatment five times in 2 weeks (Days 0, 1, 2, 7, 14) with PDT (test) or non-activated laser (control) following debridement. The primary outcome variable was PPD, and the secondary variables were clinical attachment level (CAL) and BoP. These were assessed at 3, 6 and 12 months following the interventions. Results: Greater PPD reductions were observed in the test (-0.67 ± 0.34; p=0.01) compared with the control patients (-0.04 ± 0.33; NS) after 6 months. Significant CAL gain (+0.52 ± 0.31; p=0.01) was noted for the test, but not in the control (-0.27 ± 0.52; NS) patients after 6 months. BoP percentages dcreased significantly in test (97-64%, 67%, 77%), but not control patients after 3, 6 and 12 months. Conclusions: Repeated (five times) PDT adjunctive to debridement yielded improved clinical outcomes in residual pockets in maintenance patients. The effects were best documented after 6 months. © 2009 John Wiley & Sons A/S.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_HK
dc.relation.ispartofJournal of Clinical Periodontologyen_HK
dc.subjectClinical outcomesen_HK
dc.subjectPDTen_HK
dc.subjectPeriodontal maintenanceen_HK
dc.subjectPhotodynamic therapyen_HK
dc.subjectProbing depthen_HK
dc.subjectRCTen_HK
dc.subjectSupportive periodontal therapyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshChronic Periodontitis - drug therapy - prevention & controlen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshCombined Modality Therapyen_HK
dc.subject.meshDental Plaque Indexen_HK
dc.subject.meshDental Scalingen_HK
dc.subject.meshDouble-Blind Methoden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshGingival Hemorrhage - drug therapy - prevention & controlen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLasersen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPeriodontal Attachment Loss - drug therapy - prevention & controlen_HK
dc.subject.meshPeriodontal Diseases - drug therapy - prevention & controlen_HK
dc.subject.meshPeriodontal Pocket - drug therapy - prevention & controlen_HK
dc.subject.meshPhenothiazines - therapeutic useen_HK
dc.subject.meshPhotochemotherapy - methodsen_HK
dc.subject.meshPhotosensitizing Agents - therapeutic useen_HK
dc.subject.meshRoot Planingen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleOne-year outcomes of repeated adjunctive photodynamic therapy during periodontal maintenance: A proof-of-principle randomized-controlled clinical trialen_HK
dc.typeArticleen_HK
dc.identifier.emailMattheos, N: mattheos@hku.hken_HK
dc.identifier.emailLang, NP: nplang@hkucc.hku.hken_HK
dc.identifier.authorityMattheos, N=rp01662en_HK
dc.identifier.authorityLang, NP=rp00031en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2009.01432.xen_HK
dc.identifier.pmid19563331-
dc.identifier.scopuseid_2-s2.0-68249130763en_HK
dc.identifier.hkuros182748en_HK
dc.identifier.hkuros165534-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68249130763&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue8en_HK
dc.identifier.spage661en_HK
dc.identifier.epage666en_HK
dc.identifier.isiWOS:000267880900006-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridLulic, M=16549888400en_HK
dc.identifier.scopusauthoridLeiggener Görög, I=30767655800en_HK
dc.identifier.scopusauthoridSalvi, GE=35600695300en_HK
dc.identifier.scopusauthoridRamseier, CA=8921696800en_HK
dc.identifier.scopusauthoridMattheos, N=6602862633en_HK
dc.identifier.scopusauthoridLang, NP=7201577367en_HK
dc.identifier.citeulike5405995-

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