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Article: Novel antifungal activity of purpurin against Candida species in vitro

TitleNovel antifungal activity of purpurin against Candida species in vitro
Authors
KeywordsCandida
Efflux pumps
In vitro susceptibility
Mitochondrial membrane potential
Purpurin
Issue Date2010
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13693786.asp
Citation
Medical Mycology, 2010, v. 48 n. 7, p. 904-911 How to Cite?
AbstractThe antifungal activity of purpurin (1,2,4-trihydroxy-9,10-anthraquinone), a natural red anthraquinone pigment in madder root (Rubia tinctorum L.), was evaluated by a broth microdilution assay against a total of 24 Candida isolates representing six species. The minimum inhibitory concentration (MIC) range of purpurin was 1.285.12 μg/ml. Mechanistic studies using the rhodamine 6G extrusion assay indicated that purpurin inhibited the energy-dependent efflux pumps of the Candida isolates in a dose-dependent manner. Furthermore, purpurin demonstrated a dose-dependent depolarization of mitochondrial membrane potential, one of the biochemical checkpoints regulating cell death in eukaryotic cells, suggesting a possible linkage between purpurin antifungal mechanism and Candida apoptosis. © 2010 ISHAM.
Persistent Identifierhttp://hdl.handle.net/10722/124426
ISSN
2015 Impact Factor: 2.644
2015 SCImago Journal Rankings: 1.055
ISI Accession Number ID
Funding AgencyGrant Number
Research Fund for the Control of Infectious Diseases, Food and Health Bureau of the Government of the Hong Kong SARRFCID 08070142
Funding Information:

This research was partially supported by a research grant to PWK Tsang from the Research Fund for the Control of Infectious Diseases (RFCID 08070142), the Food and Health Bureau of the Government of the Hong Kong SAR. We thank Professor L. P. Samaranayake (University of Hong Kong) for providing some of the Candida strains and Dr J. Morschhauser for C. albicans SC5314 used in this study.

References

 

DC FieldValueLanguage
dc.contributor.authorKang, Ken_HK
dc.contributor.authorFong, WPen_HK
dc.contributor.authorTsang, PWKen_HK
dc.date.accessioned2010-10-31T10:33:43Z-
dc.date.available2010-10-31T10:33:43Z-
dc.date.issued2010en_HK
dc.identifier.citationMedical Mycology, 2010, v. 48 n. 7, p. 904-911en_HK
dc.identifier.issn1369-3786en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124426-
dc.description.abstractThe antifungal activity of purpurin (1,2,4-trihydroxy-9,10-anthraquinone), a natural red anthraquinone pigment in madder root (Rubia tinctorum L.), was evaluated by a broth microdilution assay against a total of 24 Candida isolates representing six species. The minimum inhibitory concentration (MIC) range of purpurin was 1.285.12 μg/ml. Mechanistic studies using the rhodamine 6G extrusion assay indicated that purpurin inhibited the energy-dependent efflux pumps of the Candida isolates in a dose-dependent manner. Furthermore, purpurin demonstrated a dose-dependent depolarization of mitochondrial membrane potential, one of the biochemical checkpoints regulating cell death in eukaryotic cells, suggesting a possible linkage between purpurin antifungal mechanism and Candida apoptosis. © 2010 ISHAM.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13693786.aspen_HK
dc.relation.ispartofMedical Mycologyen_HK
dc.rightsMedical Mycology. Copyright © Informa Healthcare.-
dc.subjectCandidaen_HK
dc.subjectEfflux pumpsen_HK
dc.subjectIn vitro susceptibilityen_HK
dc.subjectMitochondrial membrane potentialen_HK
dc.subjectPurpurinen_HK
dc.titleNovel antifungal activity of purpurin against Candida species in vitroen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1369-3786&volume=48&issue=7&spage=904&epage=911&date=2010&atitle=Novel+antifungal+activity+of+purpurin+against+Candida+species+in+vitroen_HK
dc.identifier.emailTsang, PWK:pwktsang@hku.hken_HK
dc.identifier.authorityTsang, PWK=rp01388en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/13693781003739351en_HK
dc.identifier.pmid20392152-
dc.identifier.scopuseid_2-s2.0-77957740642en_HK
dc.identifier.hkuros175336en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957740642&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume48en_HK
dc.identifier.issue7en_HK
dc.identifier.spage904en_HK
dc.identifier.epage911en_HK
dc.identifier.eissn1460-2709-
dc.identifier.isiWOS:000284170600002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKang, K=36544735400en_HK
dc.identifier.scopusauthoridFong, WP=7102816006en_HK
dc.identifier.scopusauthoridTsang, PWK=8334953500en_HK

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