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Article: Antimicrobial efficacy of 3.8% silver diamine fluoride and its effect on root dentin

TitleAntimicrobial efficacy of 3.8% silver diamine fluoride and its effect on root dentin
Authors
KeywordsAntimicrobial
Enterococcus faecalis
irrigant
root canal medicament
silver diamine fluoride
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.jendodon.com
Citation
Journal Of Endodontics, 2010, v. 36 n. 6, p. 1026-1029 How to Cite?
AbstractIntroduction: This study investigated the use of 3.8% silver diamine fluoride (Ag[NH3]2F) as an antibacterial agent against Enterococcus faecalis biofilms and its ability to penetrate dentinal tubules by the formation of silver salts. Methods: Biofims were generated on membrane filter discs and subjected to 15-minute and 60-minute exposure times with 3.8% Ag(NH3)2F, saturated Ca(OH)2, 5.25% NaOCl (negative control), and 0.9% NaCl (positive control). Cleaned and shaped radicular dentin were applied with Ag(NH3)2F for 24, 48, and 72 hours. The presence of silver salts on the dentin surface was examined using low-pressure scanning electron microscopy. Results: Both NaOCl and Ag(NH3)2F were effective against E. faecalis biofilms, with no significant difference in reduction of microorganisms for both exposure times. Silver deposits were present on 66.5% of the radicular dentin surfaces after 72-hour application of Ag(NH3)2F as simulated interappointment dressings. Penetration of the silver deposits was observed at most 40 μm into dentinal tubules after smear layer removal. Conclusion: Ag(NH3)2F has potential to be used as an antimicrobial root canal irrigant or interappointment dressing, especially in locations in which potential browning/blackening of dentin by metallic silver is not a major concern. © 2010 Published by Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/124414
ISSN
2015 Impact Factor: 2.904
2015 SCImago Journal Rankings: 1.681
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHiraishi, Nen_HK
dc.contributor.authorYiu, CKYen_HK
dc.contributor.authorKing, NMen_HK
dc.contributor.authorTagami, Jen_HK
dc.contributor.authorTay, FRen_HK
dc.date.accessioned2010-10-31T10:33:04Z-
dc.date.available2010-10-31T10:33:04Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Endodontics, 2010, v. 36 n. 6, p. 1026-1029en_HK
dc.identifier.issn0099-2399en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124414-
dc.description.abstractIntroduction: This study investigated the use of 3.8% silver diamine fluoride (Ag[NH3]2F) as an antibacterial agent against Enterococcus faecalis biofilms and its ability to penetrate dentinal tubules by the formation of silver salts. Methods: Biofims were generated on membrane filter discs and subjected to 15-minute and 60-minute exposure times with 3.8% Ag(NH3)2F, saturated Ca(OH)2, 5.25% NaOCl (negative control), and 0.9% NaCl (positive control). Cleaned and shaped radicular dentin were applied with Ag(NH3)2F for 24, 48, and 72 hours. The presence of silver salts on the dentin surface was examined using low-pressure scanning electron microscopy. Results: Both NaOCl and Ag(NH3)2F were effective against E. faecalis biofilms, with no significant difference in reduction of microorganisms for both exposure times. Silver deposits were present on 66.5% of the radicular dentin surfaces after 72-hour application of Ag(NH3)2F as simulated interappointment dressings. Penetration of the silver deposits was observed at most 40 μm into dentinal tubules after smear layer removal. Conclusion: Ag(NH3)2F has potential to be used as an antimicrobial root canal irrigant or interappointment dressing, especially in locations in which potential browning/blackening of dentin by metallic silver is not a major concern. © 2010 Published by Elsevier Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.jendodon.comen_HK
dc.relation.ispartofJournal of Endodonticsen_HK
dc.subjectAntimicrobialen_HK
dc.subjectEnterococcus faecalisen_HK
dc.subjectirriganten_HK
dc.subjectroot canal medicamenten_HK
dc.subjectsilver diamine fluorideen_HK
dc.subject.meshAnti-Infective Agents - pharmacokinetics - pharmacology-
dc.subject.meshBacteriological Techniques-
dc.subject.meshDental Pulp Cavity - drug effects - metabolism - ultrastructure-
dc.subject.meshDentin - drug effects - metabolism - ultrastructure-
dc.subject.meshQuaternary Ammonium Compounds - pharmacokinetics - pharmacology-
dc.titleAntimicrobial efficacy of 3.8% silver diamine fluoride and its effect on root dentinen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0099-2399&volume=36&issue=6&spage=1026&epage=1029&date=2010&atitle=Anti-microbial+efficacy+of+3.8%+silver+diamine+fluoride+and+its+effect+on+root+dentin-
dc.identifier.emailYiu, CKY: ckyyiu@hkucc.hku.hken_HK
dc.identifier.emailKing, NM: hhdbknm@hkucc.hku.hken_HK
dc.identifier.authorityYiu, CKY=rp00018en_HK
dc.identifier.authorityKing, NM=rp00006en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.joen.2010.02.029en_HK
dc.identifier.pmid20478459-
dc.identifier.scopuseid_2-s2.0-77955306808en_HK
dc.identifier.hkuros174822en_HK
dc.identifier.hkuros183712-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955306808&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1026en_HK
dc.identifier.epage1029en_HK
dc.identifier.isiWOS:000278474500016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHiraishi, N=8925934400en_HK
dc.identifier.scopusauthoridYiu, CKY=7007115156en_HK
dc.identifier.scopusauthoridKing, NM=7201762850en_HK
dc.identifier.scopusauthoridTagami, J=7005967527en_HK
dc.identifier.scopusauthoridTay, FR=7102091962en_HK

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