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Article: In vitro synergistic effects of metergoline and antifungal agents against Candida krusei

TitleIn vitro synergistic effects of metergoline and antifungal agents against Candida krusei
Authors
KeywordsCandida krusei
Metergoline
Phospholipase
Synergism
Issue Date2010
PublisherWiley-Blackwell Verlag GmbH. The Journal's web site is located at http://www.blackwellpublishing.com/journals/MYC
Citation
Mycoses, 2010, v. 53 n. 6, p. 495-499 How to Cite?
AbstractMetergoline, a serotonin receptor antagonist, was evaluated for its antifungal activity against the opportunistic human fungal pathogen Candida krusei by a broth microdilution assay. The minimal inhibitory concentration and minimal fungicidal concentration of metergoline against C. krusei were 4 and 8 μg ml -1 respectively. Significant synergism was found in combination of metergoline with amphotericin B (fractional inhibitory concentration index: 0.375-0.5) by a chequerboard assay. Metergoline also inhibited extracellular phospholipase secretion in a dose-dependent manner, which may be a possible action mechanism of metergoline on C. krusei. © 2009 Blackwell Verlag GmbH.
Persistent Identifierhttp://hdl.handle.net/10722/124413
ISSN
2015 Impact Factor: 2.332
2015 SCImago Journal Rankings: 0.921
ISI Accession Number ID
Funding AgencyGrant Number
Chinese University of Hong Kong4450125
Funding Information:

This study was supported by the RGC Research Grant Direct Allocation of The Chinese University of Hong Kong (Project number: 4450125 to P. W. K. Tsang).

References

 

DC FieldValueLanguage
dc.contributor.authorKang, Ken_HK
dc.contributor.authorWong, KSen_HK
dc.contributor.authorJayampath Seneviratne, Cen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.contributor.authorFong, WPen_HK
dc.contributor.authorTsang, PWKen_HK
dc.date.accessioned2010-10-31T10:33:00Z-
dc.date.available2010-10-31T10:33:00Z-
dc.date.issued2010en_HK
dc.identifier.citationMycoses, 2010, v. 53 n. 6, p. 495-499en_HK
dc.identifier.issn0933-7407en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124413-
dc.description.abstractMetergoline, a serotonin receptor antagonist, was evaluated for its antifungal activity against the opportunistic human fungal pathogen Candida krusei by a broth microdilution assay. The minimal inhibitory concentration and minimal fungicidal concentration of metergoline against C. krusei were 4 and 8 μg ml -1 respectively. Significant synergism was found in combination of metergoline with amphotericin B (fractional inhibitory concentration index: 0.375-0.5) by a chequerboard assay. Metergoline also inhibited extracellular phospholipase secretion in a dose-dependent manner, which may be a possible action mechanism of metergoline on C. krusei. © 2009 Blackwell Verlag GmbH.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Verlag GmbH. The Journal's web site is located at http://www.blackwellpublishing.com/journals/MYCen_HK
dc.relation.ispartofMycosesen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectCandida kruseien_HK
dc.subjectMetergolineen_HK
dc.subjectPhospholipaseen_HK
dc.subjectSynergismen_HK
dc.titleIn vitro synergistic effects of metergoline and antifungal agents against Candida kruseien_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0933-7407&volume=53&issue=6&spage=495&epage=499&date=2010&atitle=In+vitro+synergistic+effects+of+metergoline+and+antifungal+agents+against+Candida+krusei-
dc.identifier.emailJayampath Seneviratne, C:jaya@hku.hken_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.emailTsang, PWK:pwktsang@hku.hken_HK
dc.identifier.authorityJayampath Seneviratne, C=rp01372en_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.identifier.authorityTsang, PWK=rp01388en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1439-0507.2009.01747.xen_HK
dc.identifier.pmid19538518-
dc.identifier.scopuseid_2-s2.0-77958088355en_HK
dc.identifier.hkuros175339en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77958088355&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue6en_HK
dc.identifier.spage495en_HK
dc.identifier.epage499en_HK
dc.identifier.eissn1439-0507-
dc.identifier.isiWOS:000282568800006-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridKang, K=37034237900en_HK
dc.identifier.scopusauthoridWong, KS=35191126000en_HK
dc.identifier.scopusauthoridJayampath Seneviratne, C=6701897753en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.scopusauthoridFong, WP=7102816006en_HK
dc.identifier.scopusauthoridTsang, PWK=8334953500en_HK
dc.identifier.citeulike8017546-

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