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Article: Dual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands

TitleDual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands
Authors
Issue Date2009
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/dalton
Citation
Dalton Transactions, 2009 n. 48, p. 10712-10716 How to Cite?
AbstractAn oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60%, 48 h) against HeLa cells at 10 μM level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear ruthenium(III) complexes containing pyrazole ligands [Ru(pz)4X2] + exhibit dual anti-angiogenic and cytotoxic properties. © The Royal Society of Chemistry 2009.
Persistent Identifierhttp://hdl.handle.net/10722/124067
ISSN
2015 Impact Factor: 4.177
2015 SCImago Journal Rankings: 1.404
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorNg, MFYen_HK
dc.contributor.authorWong, ELMen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorChui, SSYen_HK
dc.contributor.authorShek, Len_HK
dc.contributor.authorLau, TCen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2010-10-20T02:53:41Z-
dc.date.available2010-10-20T02:53:41Z-
dc.date.issued2009en_HK
dc.identifier.citationDalton Transactions, 2009 n. 48, p. 10712-10716en_HK
dc.identifier.issn1477-9226en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124067-
dc.description.abstractAn oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60%, 48 h) against HeLa cells at 10 μM level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear ruthenium(III) complexes containing pyrazole ligands [Ru(pz)4X2] + exhibit dual anti-angiogenic and cytotoxic properties. © The Royal Society of Chemistry 2009.en_HK
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/daltonen_HK
dc.relation.ispartofDalton Transactionsen_HK
dc.subject.meshAngiogenesis Inhibitors - chemistry - pharmacology-
dc.subject.meshCoordination Complexes - chemistry - toxicity-
dc.subject.meshLigands-
dc.subject.meshPyrazoles - chemistry-
dc.subject.meshRuthenium - chemistry-
dc.titleDual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligandsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1477-9226&volume=48&spage=10712&epage=10716&date=2009&atitle=Dual+anti-angiogenic+and+cytotoxic+properties+of+ruthenium(III)+complexes+containing+pyrazolato+and/or+pyrazole+ligands-
dc.identifier.emailSun, RWY: rwysun@hku.hken_HK
dc.identifier.emailWong, ELM: wongella@hku.hken_HK
dc.identifier.emailChui, SSY: chuissy@hkucc.hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authorityWong, ELM=rp00807en_HK
dc.identifier.authorityChui, SSY=rp00686en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/b912236ben_HK
dc.identifier.pmid20023898-
dc.identifier.scopuseid_2-s2.0-71549116074en_HK
dc.identifier.hkuros172618-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-71549116074&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume48-
dc.identifier.issue48en_HK
dc.identifier.spage10712en_HK
dc.identifier.epage10716en_HK
dc.identifier.isiWOS:000272359900009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSun, RWY=26325835800en_HK
dc.identifier.scopusauthoridNg, MFY=8297452900en_HK
dc.identifier.scopusauthoridWong, ELM=8944839700en_HK
dc.identifier.scopusauthoridZhang, J=35742328100en_HK
dc.identifier.scopusauthoridChui, SSY=8297453100en_HK
dc.identifier.scopusauthoridShek, L=35741917300en_HK
dc.identifier.scopusauthoridLau, TC=7102222310en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK

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