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Article: Reliability and reproducibility of perfusion MRI in cognitively normal subjects

TitleReliability and reproducibility of perfusion MRI in cognitively normal subjects
Authors
KeywordsArterial spin labeling
Cerebral blood flow
Perfusion
Reliability
Reproducibility
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/mri
Citation
Magnetic Resonance Imaging, 2010, v. 28 n. 9, p. 1283-1289 How to Cite?
AbstractArterial spin labeling (ASL) magnetic resonance imaging (MRI) is becoming a popular method for measuring perfusion due to its ability of generating perfusion maps noninvasively. This allows for frequent repeat scanning, which is especially useful for follow-up studies. However, limited information is available regarding the reliability and reproducibility of ASL perfusion measurements. Here, the reliability and reproducibility of pulsed ASL was investigated in an elderly population to determine the variation in perfusion among cognitively normal individuals in different brain structures. Intraclass correlation coefficients (ICC) and within-subject variation coefficients (wsCV) were used to estimate reliability and reproducibility over a period of 1 year. Twelve cognitively normal subjects (75.5±5.3 years old, six male and six female) were scanned four times (at 0, 3, 6 and 12 months). No significant difference in cerebral blood flow (CBF) was found over this period. CBF values ranged from 46 to 53 ml/100 g per minute in the medial frontal gyrus (MFG) and from 40 to 44 ml/100 g per minute over all gray matter regions in the superior part of the brain. Data obtained from the first two scans were processed by two readers and showed high reliability (ICC >0.97) and reproducibility (wsCV <6%). However, over the total period of 1 year, reliability reduced to a moderate level (ICC=0.63-0.74) with wsCVs of gray matter, left MFG, right MFG of 13.5%, 12.3%, and 15.4%, respectively. In conclusion, measurement of CBF with pulsed ASL provided good agreement between inter-raters. A moderate level of reliability was obtained over a 1-year period, which was attributed to variance in slice positioning and coregistration. As such pulsed ASL has the potential to be used for CBF comparison in longitudinal studies. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/123994
ISSN
2015 Impact Factor: 1.98
2015 SCImago Journal Rankings: 1.139
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Glaxo Smith Kline
NIH (NCRR)P41015241
National Center for Research Resources (NCRR), National Institutes of Health (NIH)P41 RR015241
Funding Information:

This work was supported by grants from Glaxo Smith Kline and NIH (NCRR P41015241). The authors are grateful to Terri Brawner, Kathleen Kahl, Ivana Kusevic and Joe Gillen for experimental assistance. Dr. Kim is supported by a grant from Philips Medical Systems to Kennedy Krieger Research Institute. One of the supporting agencies, the National Center for Research Resources (NCRR, P41 RR015241), is a component of the National Institutes of Health (NIH). The content of this paper is solely the responsibility of the authors and does not necessarily represent the official view of NCRR or NIH. Dr. van Zijl is a paid lecturer for Philips Medical Systems. This arrangement has been approved by Johns Hopkins University in accordance with its conflict of interest policies.

References

 

DC FieldValueLanguage
dc.contributor.authorJiang, Len_HK
dc.contributor.authorKim, Men_HK
dc.contributor.authorChodkowski, Ben_HK
dc.contributor.authorDonahue, MJen_HK
dc.contributor.authorPekar, JJen_HK
dc.contributor.authorVan Zijl, PCMen_HK
dc.contributor.authorAlbert, Men_HK
dc.date.accessioned2010-10-18T02:12:11Z-
dc.date.available2010-10-18T02:12:11Z-
dc.date.issued2010en_HK
dc.identifier.citationMagnetic Resonance Imaging, 2010, v. 28 n. 9, p. 1283-1289en_HK
dc.identifier.issn0730-725Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/123994-
dc.description.abstractArterial spin labeling (ASL) magnetic resonance imaging (MRI) is becoming a popular method for measuring perfusion due to its ability of generating perfusion maps noninvasively. This allows for frequent repeat scanning, which is especially useful for follow-up studies. However, limited information is available regarding the reliability and reproducibility of ASL perfusion measurements. Here, the reliability and reproducibility of pulsed ASL was investigated in an elderly population to determine the variation in perfusion among cognitively normal individuals in different brain structures. Intraclass correlation coefficients (ICC) and within-subject variation coefficients (wsCV) were used to estimate reliability and reproducibility over a period of 1 year. Twelve cognitively normal subjects (75.5±5.3 years old, six male and six female) were scanned four times (at 0, 3, 6 and 12 months). No significant difference in cerebral blood flow (CBF) was found over this period. CBF values ranged from 46 to 53 ml/100 g per minute in the medial frontal gyrus (MFG) and from 40 to 44 ml/100 g per minute over all gray matter regions in the superior part of the brain. Data obtained from the first two scans were processed by two readers and showed high reliability (ICC >0.97) and reproducibility (wsCV <6%). However, over the total period of 1 year, reliability reduced to a moderate level (ICC=0.63-0.74) with wsCVs of gray matter, left MFG, right MFG of 13.5%, 12.3%, and 15.4%, respectively. In conclusion, measurement of CBF with pulsed ASL provided good agreement between inter-raters. A moderate level of reliability was obtained over a 1-year period, which was attributed to variance in slice positioning and coregistration. As such pulsed ASL has the potential to be used for CBF comparison in longitudinal studies. © 2010 Elsevier Inc.en_HK
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/mrien_HK
dc.relation.ispartofMagnetic Resonance Imagingen_HK
dc.rightsMagnetic Resonance Imaging. Copyright © Elsevier Inc.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectArterial spin labelingen_HK
dc.subjectCerebral blood flowen_HK
dc.subjectPerfusionen_HK
dc.subjectReliabilityen_HK
dc.subjectReproducibilityen_HK
dc.titleReliability and reproducibility of perfusion MRI in cognitively normal subjectsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0730-725X&volume=&spage=In Press, Corrected Proof&epage=&date=2010&atitle=Reliability+and+reproducibility+of+perfusion+MRI+in+cognitively+normal+subjects-
dc.identifier.emailKim, M:minakim@hku.hken_HK
dc.identifier.authorityKim, M=rp00292en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.mri.2010.05.002en_HK
dc.identifier.pmid20573464-
dc.identifier.pmcidPMC2963675-
dc.identifier.scopuseid_2-s2.0-77958185368en_HK
dc.identifier.hkuros172580-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77958185368&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1283en_HK
dc.identifier.epage1289en_HK
dc.identifier.isiWOS:000283906800004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJiang, L=36076725200en_HK
dc.identifier.scopusauthoridKim, M=8146283400en_HK
dc.identifier.scopusauthoridChodkowski, B=22955683300en_HK
dc.identifier.scopusauthoridDonahue, MJ=7102453283en_HK
dc.identifier.scopusauthoridPekar, JJ=7003771238en_HK
dc.identifier.scopusauthoridVan Zijl, PCM=7006760849en_HK
dc.identifier.scopusauthoridAlbert, M=7403276705en_HK
dc.identifier.citeulike7400480-

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