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Article: Rapid magnetic-mediated solid-phase extraction and pre-concentration of selected endocrine disrupting chemicals in natural waters by poly(divinylbenzene-co-methacrylic acid) coated Fe3O4 core-shell magnetite microspheres for their liquid chromatography-tandem mass spectrometry determination

TitleRapid magnetic-mediated solid-phase extraction and pre-concentration of selected endocrine disrupting chemicals in natural waters by poly(divinylbenzene-co-methacrylic acid) coated Fe3O4 core-shell magnetite microspheres for their liquid chromatography-tandem mass spectrometry determination
Authors
KeywordsCore-shell microspheres
Endocrine disrupting chemicals
Estrogen mimics
Magnetite microspheres
Solid-phase extraction
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/chroma
Citation
Journal Of Chromatography A, 2010, v. 1217 n. 8, p. 1219-1226 How to Cite?
AbstractA new Fe3O4/poly(divinylbenzene-co-methacrylic acid) core-shell magnetite microspheric material have been successfully developed as magnetic-mediated solid-phase extraction micro-particle sorbent in dispersion mode (MM-SPE-MP) for the determination of selected estrogenic endocrine disrupting chemicals (EDCs), namely: estrone (E1), 17β-estradiol (E2), estriol (E3), 17α-ethynylestradiol (EE2) and bisphenol-A (BPA), in natural water, via quantification by HPLC tandem mass spectrometry. The magnetite Fe3O4 core of this MM-SPE-MP sorbent was fabricated by a solvothermal approach and the thin layer of amphipolar poly(divinylbenzene-co-methacrylic acid) (pDVB-MAA) coating was established via suspension polymerization. The resultant core-shell MM-SPE-MP sorbent material was characterized by electron microscopy, X-ray diffraction and Fourier-transformed infrared spectroscopy. Particle size distribution of the core-shell microspheres was within the range 300-700 nm in diameter and the thickness of the pDVB-MAA coating was ca. 10 nm. This magnetite microspheric material can be easily dispersed in aqueous samples and retrieved by the application of external magnetic field via a small piece of permanent magnet. The MM-SPE-MP process for the selected estrogenic EDCs involved the dispersion of the core-shell microspheric sorbent in water samples with sonication, followed by magnetic aided retrieval of the sorbent and solvent (methanol) desorption of extracted EDCs for LC-MS/MS analysis. Partition equilibrium for all the selected EDCs onto this MM-SPE-MP sorbent was achieved within 15 min. Recoveries of the EDCs were in ranges of 56-111%. Analytes with smaller KOW value showed relatively lower recovery (and relatively longer equilibration time for partitioning). Method detection limits achieved were found to be 1-36 pg ml-1 (n = 3), while the repeatability was 6-34% (p < 0.05, n = 3). This work demonstrates the usefulness of MM-SPE-MP in the rapid and highly sensitive monitoring of trace organic contaminants in natural waters. © 2009 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/123981
ISSN
2014 Impact Factor: 4.169
2014 SCImago Journal Rankings: 1.664
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Special Administrative Region. ChinaAoE/P-04/2004
Shenzhen-HongKong Innovative Circle of Shenzhen City
Funding Information:

The work described in this paper was Supported by the Areas of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region. China (Project no. AoE/P-04/2004) and a grant from Shenzhen-HongKong Innovative Circle of Shenzhen City (Project no 08df-01)

References

 

DC FieldValueLanguage
dc.contributor.authorLi, Qen_HK
dc.contributor.authorLam, MHWen_HK
dc.contributor.authorWu, RSSen_HK
dc.contributor.authorJiang, Ben_HK
dc.date.accessioned2010-10-15T03:07:44Z-
dc.date.available2010-10-15T03:07:44Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Chromatography A, 2010, v. 1217 n. 8, p. 1219-1226en_HK
dc.identifier.issn0021-9673en_HK
dc.identifier.urihttp://hdl.handle.net/10722/123981-
dc.description.abstractA new Fe3O4/poly(divinylbenzene-co-methacrylic acid) core-shell magnetite microspheric material have been successfully developed as magnetic-mediated solid-phase extraction micro-particle sorbent in dispersion mode (MM-SPE-MP) for the determination of selected estrogenic endocrine disrupting chemicals (EDCs), namely: estrone (E1), 17β-estradiol (E2), estriol (E3), 17α-ethynylestradiol (EE2) and bisphenol-A (BPA), in natural water, via quantification by HPLC tandem mass spectrometry. The magnetite Fe3O4 core of this MM-SPE-MP sorbent was fabricated by a solvothermal approach and the thin layer of amphipolar poly(divinylbenzene-co-methacrylic acid) (pDVB-MAA) coating was established via suspension polymerization. The resultant core-shell MM-SPE-MP sorbent material was characterized by electron microscopy, X-ray diffraction and Fourier-transformed infrared spectroscopy. Particle size distribution of the core-shell microspheres was within the range 300-700 nm in diameter and the thickness of the pDVB-MAA coating was ca. 10 nm. This magnetite microspheric material can be easily dispersed in aqueous samples and retrieved by the application of external magnetic field via a small piece of permanent magnet. The MM-SPE-MP process for the selected estrogenic EDCs involved the dispersion of the core-shell microspheric sorbent in water samples with sonication, followed by magnetic aided retrieval of the sorbent and solvent (methanol) desorption of extracted EDCs for LC-MS/MS analysis. Partition equilibrium for all the selected EDCs onto this MM-SPE-MP sorbent was achieved within 15 min. Recoveries of the EDCs were in ranges of 56-111%. Analytes with smaller KOW value showed relatively lower recovery (and relatively longer equilibration time for partitioning). Method detection limits achieved were found to be 1-36 pg ml-1 (n = 3), while the repeatability was 6-34% (p < 0.05, n = 3). This work demonstrates the usefulness of MM-SPE-MP in the rapid and highly sensitive monitoring of trace organic contaminants in natural waters. © 2009 Elsevier B.V. All rights reserved.en_HK
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/chromaen_HK
dc.relation.ispartofJournal of Chromatography Aen_HK
dc.rightsJournal of Chromatography A. Copyright © Elsevier BV.-
dc.subjectCore-shell microspheresen_HK
dc.subjectEndocrine disrupting chemicalsen_HK
dc.subjectEstrogen mimicsen_HK
dc.subjectMagnetite microspheresen_HK
dc.subjectSolid-phase extractionen_HK
dc.titleRapid magnetic-mediated solid-phase extraction and pre-concentration of selected endocrine disrupting chemicals in natural waters by poly(divinylbenzene-co-methacrylic acid) coated Fe3O4 core-shell magnetite microspheres for their liquid chromatography-tandem mass spectrometry determinationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9673&volume=1217&issue=8&spage=1219&epage=1226&date=2010&atitle=Rapid+magnetic-mediated+solid-phase+extraction+and+pre-concentration+of+selected+endocrine+disrupting+chemicals+in+natural+waters+by+poly(divinylbenzene-co-methacrylic+acid)+coated+Fe3O4+core-shell+magnetite+microspheres+for+their+liquid+chromatography-tandem+mass+spectrometry+determination-
dc.identifier.emailWu, RSS: rudolfwu@hku.hken_HK
dc.identifier.authorityWu, RSS=rp01398en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.chroma.2009.12.035en_HK
dc.identifier.pmid20047750-
dc.identifier.scopuseid_2-s2.0-74849139034en_HK
dc.identifier.hkuros172463-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-74849139034&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1217en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1219en_HK
dc.identifier.epage1226en_HK
dc.identifier.isiWOS:000274953400005-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLi, Q=15843515400en_HK
dc.identifier.scopusauthoridLam, MHW=7202630175en_HK
dc.identifier.scopusauthoridWu, RSS=7402945079en_HK
dc.identifier.scopusauthoridJiang, B=35334287200en_HK
dc.identifier.citeulike6409784-

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