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Article: Rapid magnetic-mediated solid-phase extraction and pre-concentration of selected endocrine disrupting chemicals in natural waters by poly(divinylbenzene-co-methacrylic acid) coated Fe3O4 core-shell magnetite microspheres for their liquid chromatography-tandem mass spectrometry determination
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TitleRapid magnetic-mediated solid-phase extraction and pre-concentration of selected endocrine disrupting chemicals in natural waters by poly(divinylbenzene-co-methacrylic acid) coated Fe3O4 core-shell magnetite microspheres for their liquid chromatography-tandem mass spectrometry determination
 
AuthorsLi, Q1
Lam, MHW1
Wu, RSS1
Jiang, B2
 
KeywordsCore-shell microspheres
Endocrine disrupting chemicals
Estrogen mimics
Magnetite microspheres
Solid-phase extraction
 
Issue Date2010
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/chroma
 
CitationJournal Of Chromatography A, 2010, v. 1217 n. 8, p. 1219-1226 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.chroma.2009.12.035
 
AbstractA new Fe3O4/poly(divinylbenzene-co-methacrylic acid) core-shell magnetite microspheric material have been successfully developed as magnetic-mediated solid-phase extraction micro-particle sorbent in dispersion mode (MM-SPE-MP) for the determination of selected estrogenic endocrine disrupting chemicals (EDCs), namely: estrone (E1), 17β-estradiol (E2), estriol (E3), 17α-ethynylestradiol (EE2) and bisphenol-A (BPA), in natural water, via quantification by HPLC tandem mass spectrometry. The magnetite Fe3O4 core of this MM-SPE-MP sorbent was fabricated by a solvothermal approach and the thin layer of amphipolar poly(divinylbenzene-co-methacrylic acid) (pDVB-MAA) coating was established via suspension polymerization. The resultant core-shell MM-SPE-MP sorbent material was characterized by electron microscopy, X-ray diffraction and Fourier-transformed infrared spectroscopy. Particle size distribution of the core-shell microspheres was within the range 300-700 nm in diameter and the thickness of the pDVB-MAA coating was ca. 10 nm. This magnetite microspheric material can be easily dispersed in aqueous samples and retrieved by the application of external magnetic field via a small piece of permanent magnet. The MM-SPE-MP process for the selected estrogenic EDCs involved the dispersion of the core-shell microspheric sorbent in water samples with sonication, followed by magnetic aided retrieval of the sorbent and solvent (methanol) desorption of extracted EDCs for LC-MS/MS analysis. Partition equilibrium for all the selected EDCs onto this MM-SPE-MP sorbent was achieved within 15 min. Recoveries of the EDCs were in ranges of 56-111%. Analytes with smaller KOW value showed relatively lower recovery (and relatively longer equilibration time for partitioning). Method detection limits achieved were found to be 1-36 pg ml-1 (n = 3), while the repeatability was 6-34% (p < 0.05, n = 3). This work demonstrates the usefulness of MM-SPE-MP in the rapid and highly sensitive monitoring of trace organic contaminants in natural waters. © 2009 Elsevier B.V. All rights reserved.
 
ISSN0021-9673
2012 Impact Factor: 4.612
2012 SCImago Journal Rankings: 2.015
 
DOIhttp://dx.doi.org/10.1016/j.chroma.2009.12.035
 
ISI Accession Number IDWOS:000274953400005
Funding AgencyGrant Number
Hong Kong Special Administrative Region. ChinaAoE/P-04/2004
Shenzhen-HongKong Innovative Circle of Shenzhen City
Funding Information:

The work described in this paper was Supported by the Areas of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region. China (Project no. AoE/P-04/2004) and a grant from Shenzhen-HongKong Innovative Circle of Shenzhen City (Project no 08df-01)

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLi, Q
 
dc.contributor.authorLam, MHW
 
dc.contributor.authorWu, RSS
 
dc.contributor.authorJiang, B
 
dc.date.accessioned2010-10-15T03:07:44Z
 
dc.date.available2010-10-15T03:07:44Z
 
dc.date.issued2010
 
dc.description.abstractA new Fe3O4/poly(divinylbenzene-co-methacrylic acid) core-shell magnetite microspheric material have been successfully developed as magnetic-mediated solid-phase extraction micro-particle sorbent in dispersion mode (MM-SPE-MP) for the determination of selected estrogenic endocrine disrupting chemicals (EDCs), namely: estrone (E1), 17β-estradiol (E2), estriol (E3), 17α-ethynylestradiol (EE2) and bisphenol-A (BPA), in natural water, via quantification by HPLC tandem mass spectrometry. The magnetite Fe3O4 core of this MM-SPE-MP sorbent was fabricated by a solvothermal approach and the thin layer of amphipolar poly(divinylbenzene-co-methacrylic acid) (pDVB-MAA) coating was established via suspension polymerization. The resultant core-shell MM-SPE-MP sorbent material was characterized by electron microscopy, X-ray diffraction and Fourier-transformed infrared spectroscopy. Particle size distribution of the core-shell microspheres was within the range 300-700 nm in diameter and the thickness of the pDVB-MAA coating was ca. 10 nm. This magnetite microspheric material can be easily dispersed in aqueous samples and retrieved by the application of external magnetic field via a small piece of permanent magnet. The MM-SPE-MP process for the selected estrogenic EDCs involved the dispersion of the core-shell microspheric sorbent in water samples with sonication, followed by magnetic aided retrieval of the sorbent and solvent (methanol) desorption of extracted EDCs for LC-MS/MS analysis. Partition equilibrium for all the selected EDCs onto this MM-SPE-MP sorbent was achieved within 15 min. Recoveries of the EDCs were in ranges of 56-111%. Analytes with smaller KOW value showed relatively lower recovery (and relatively longer equilibration time for partitioning). Method detection limits achieved were found to be 1-36 pg ml-1 (n = 3), while the repeatability was 6-34% (p < 0.05, n = 3). This work demonstrates the usefulness of MM-SPE-MP in the rapid and highly sensitive monitoring of trace organic contaminants in natural waters. © 2009 Elsevier B.V. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Chromatography A, 2010, v. 1217 n. 8, p. 1219-1226 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.chroma.2009.12.035
 
dc.identifier.citeulike6409784
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.chroma.2009.12.035
 
dc.identifier.epage1226
 
dc.identifier.hkuros172463
 
dc.identifier.isiWOS:000274953400005
Funding AgencyGrant Number
Hong Kong Special Administrative Region. ChinaAoE/P-04/2004
Shenzhen-HongKong Innovative Circle of Shenzhen City
Funding Information:

The work described in this paper was Supported by the Areas of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region. China (Project no. AoE/P-04/2004) and a grant from Shenzhen-HongKong Innovative Circle of Shenzhen City (Project no 08df-01)

 
dc.identifier.issn0021-9673
2012 Impact Factor: 4.612
2012 SCImago Journal Rankings: 2.015
 
dc.identifier.issue8
 
dc.identifier.openurl
 
dc.identifier.pmid20047750
 
dc.identifier.scopuseid_2-s2.0-74849139034
 
dc.identifier.spage1219
 
dc.identifier.urihttp://hdl.handle.net/10722/123981
 
dc.identifier.volume1217
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/chroma
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofJournal of Chromatography A
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Chromatography A. Copyright © Elsevier BV.
 
dc.subjectCore-shell microspheres
 
dc.subjectEndocrine disrupting chemicals
 
dc.subjectEstrogen mimics
 
dc.subjectMagnetite microspheres
 
dc.subjectSolid-phase extraction
 
dc.titleRapid magnetic-mediated solid-phase extraction and pre-concentration of selected endocrine disrupting chemicals in natural waters by poly(divinylbenzene-co-methacrylic acid) coated Fe3O4 core-shell magnetite microspheres for their liquid chromatography-tandem mass spectrometry determination
 
dc.typeArticle
 
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Author Affiliations
  1. City University of Hong Kong
  2. Graduate School at Shenzhen