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Article: Differential replication of avian influenza H9N2 viruses in human alveolar epithelial A549 cells.

TitleDifferential replication of avian influenza H9N2 viruses in human alveolar epithelial A549 cells.
Authors
Issue Date2010
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.virologyj.com/home/
Citation
Virology Journal, 2010, v. 7, p. 71 How to Cite?
AbstractAvian influenza virus H9N2 isolates cause a mild influenza-like illness in humans. However, the pathogenesis of the H9N2 subtypes in human remains to be investigated. Using a human alveolar epithelial cell line A549 as host, we found that A/Quail/Hong Kong/G1/97 (H9N2/G1), which shares 6 viral "internal genes" with the lethal A/Hong Kong/156/97 (H5N1/97) virus, replicates efficiently whereas other H9N2 viruses, A/Duck/Hong Kong/Y280/97 (H9N2/Y280) and A/Chicken/Hong Kong/G9/97 (H9N2/G9), replicate poorly. Interestingly, we found that there is a difference in the translation of viral protein but not in the infectivity or transcription of viral genes of these H9N2 viruses in the infected cells. This difference may possibly be explained by H9N2/G1 being more efficient on viral protein production in specific cell types. These findings suggest that the H9N2/G1 virus like its counterpart H5N1/97 may be better adapted to the human host and replicates efficiently in human alveolar epithelial cells.
Persistent Identifierhttp://hdl.handle.net/10722/123948
ISSN
2015 Impact Factor: 2.362
2015 SCImago Journal Rankings: 1.166
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Research Fund for the Control of Infectious Diseases09080832
Research Grants Council of Hong KongHKU1/05C
Funding Information:

This work was supported by research grants to Allan SY Lau from the Research Fund for the Control of Infectious Diseases (ref. no. 09080832), and to Malik Peiris and ASY Lau from Central Allocation Grant - Research Grants Council of Hong Kong (HKU1/05C).

Grants

 

DC FieldValueLanguage
dc.contributor.authorLee, DCen_HK
dc.contributor.authorMok, CKen_HK
dc.contributor.authorLaw, AHen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorLau, ASen_HK
dc.date.accessioned2010-10-12T06:07:32Z-
dc.date.available2010-10-12T06:07:32Z-
dc.date.issued2010en_HK
dc.identifier.citationVirology Journal, 2010, v. 7, p. 71en_HK
dc.identifier.issn1743-422Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/123948-
dc.description.abstractAvian influenza virus H9N2 isolates cause a mild influenza-like illness in humans. However, the pathogenesis of the H9N2 subtypes in human remains to be investigated. Using a human alveolar epithelial cell line A549 as host, we found that A/Quail/Hong Kong/G1/97 (H9N2/G1), which shares 6 viral "internal genes" with the lethal A/Hong Kong/156/97 (H5N1/97) virus, replicates efficiently whereas other H9N2 viruses, A/Duck/Hong Kong/Y280/97 (H9N2/Y280) and A/Chicken/Hong Kong/G9/97 (H9N2/G9), replicate poorly. Interestingly, we found that there is a difference in the translation of viral protein but not in the infectivity or transcription of viral genes of these H9N2 viruses in the infected cells. This difference may possibly be explained by H9N2/G1 being more efficient on viral protein production in specific cell types. These findings suggest that the H9N2/G1 virus like its counterpart H5N1/97 may be better adapted to the human host and replicates efficiently in human alveolar epithelial cells.en_HK
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.virologyj.com/home/en_HK
dc.relation.ispartofVirology journalen_HK
dc.subject.meshCell Line-
dc.subject.meshEpithelial Cells - virology-
dc.subject.meshInfluenza A Virus, H9N2 Subtype - growth and development - physiology-
dc.subject.meshPulmonary Alveoli - virology-
dc.subject.meshVirus Replication-
dc.titleDifferential replication of avian influenza H9N2 viruses in human alveolar epithelial A549 cells.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0042-6822&volume=7&issue=71&spage=1&epage=5&date=2010&atitle=Differential+replication+of+avian+influenza+H9N2+viruses+in+human+alveolar+epithelial+A549+cells-
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.emailLau, AS: asylau@hku.hken_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.identifier.authorityLau, AS=rp00474en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1743-422X-7-71en_HK
dc.identifier.pmid20334690-
dc.identifier.pmcidPMC2867802-
dc.identifier.scopuseid_2-s2.0-77953726301en_HK
dc.identifier.hkuros171874-
dc.identifier.volume7en_HK
dc.identifier.issue71-
dc.identifier.spage71en_HK
dc.identifier.epage71en_HK
dc.identifier.isiWOS:000277429400001-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectCellular response to influenza virus infection: effect of autophagy versus apoptosis on virus replication-
dc.identifier.scopusauthoridLee, DC=15751156000en_HK
dc.identifier.scopusauthoridMok, CK=55230327600en_HK
dc.identifier.scopusauthoridLaw, AH=36159658400en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridLau, AS=7202626202en_HK
dc.identifier.citeulike6912000-

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