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Article: Comparative epidemiology of pandemic and seasonal influenza A in households

TitleComparative epidemiology of pandemic and seasonal influenza A in households
Authors
Issue Date2010
PublisherMassachusetts Medical Society. The Journal's web site is located at http://content.nejm.org/
Citation
New England Journal Of Medicine, 2010, v. 362 n. 23, p. 2175-2184 How to Cite?
AbstractBackground: There are few data on the comparative epidemiology and virology of the pandemic 2009 influenza A (H1N1) virus and cocirculating seasonal influenza A viruses in community settings. Methods: We recruited 348 index patients with acute respiratory illness from 14 outpatient clinics in Hong Kong in July and August 2009. We then prospectively followed household members of 99 patients who tested positive for influenza A virus on rapid diagnostic testing. We collected nasal and throat swabs from all household members at three home visits within 7 days for testing by means of quantitative reverse-transcriptase- polymerase-chain-reaction (RT-PCR) assay and viral culture. Using hemagglutination-inhibition and viral-neutralization assays, we tested baseline and convalescent serum samples from a subgroup of patients for antibody responses to the pandemic and seasonal influenza A viruses. Results: Secondary attack rates (as confirmed on RT-PCR assay) among household contacts of index patients were similar for the pandemic influenza virus (8%; 95% confidence interval [CI], 3 to 14) and seasonal influenza viruses (9%; 95% CI, 5 to 15). The patterns of viral shedding and the course of illness among index patients were also similar for the pandemic and seasonal influenza viruses. In a subgroup of patients for whom baseline and convalescent serum samples were available, 36% of household contacts who had serologic evidence of pandemic influenza virus infection did not shed detectable virus or report illness. Conclusions: Pandemic 2009 H1N1 virus has characteristics that are broadly similar to those of seasonal influenza A viruses in terms of rates of viral shedding, clinical illness, and transmissibility in the household setting. Copyright © 2010 Massachusetts Medical Society. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/123945
ISSN
2015 Impact Factor: 59.558
2015 SCImago Journal Rankings: 14.619
ISI Accession Number ID
Funding AgencyGrant Number
National Institute of Allergy and Infectious DiseasesHHS-N266200700005C
N01-AI-70005
Hong Kong University Grants CommitteeAoE/M-12/06
Funding Information:

Supported by grants from the National Institute of Allergy and Infectious Diseases (HHS-N266200700005C and N01-AI-70005) and the Hong Kong University Grants Committee (AoE/M-12/06).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorCowling, BJen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorFang, VJen_HK
dc.contributor.authorLau, LLHen_HK
dc.contributor.authorSo, HCen_HK
dc.contributor.authorFung, ROPen_HK
dc.contributor.authorMa, ESKen_HK
dc.contributor.authorKwong, ASKen_HK
dc.contributor.authorChan, CWen_HK
dc.contributor.authorTsui, WWSen_HK
dc.contributor.authorNgai, HYen_HK
dc.contributor.authorChu, DWSen_HK
dc.contributor.authorLee, PWYen_HK
dc.contributor.authorChiu, MCen_HK
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2010-10-12T03:38:11Z-
dc.date.available2010-10-12T03:38:11Z-
dc.date.issued2010en_HK
dc.identifier.citationNew England Journal Of Medicine, 2010, v. 362 n. 23, p. 2175-2184en_HK
dc.identifier.issn0028-4793en_HK
dc.identifier.urihttp://hdl.handle.net/10722/123945-
dc.description.abstractBackground: There are few data on the comparative epidemiology and virology of the pandemic 2009 influenza A (H1N1) virus and cocirculating seasonal influenza A viruses in community settings. Methods: We recruited 348 index patients with acute respiratory illness from 14 outpatient clinics in Hong Kong in July and August 2009. We then prospectively followed household members of 99 patients who tested positive for influenza A virus on rapid diagnostic testing. We collected nasal and throat swabs from all household members at three home visits within 7 days for testing by means of quantitative reverse-transcriptase- polymerase-chain-reaction (RT-PCR) assay and viral culture. Using hemagglutination-inhibition and viral-neutralization assays, we tested baseline and convalescent serum samples from a subgroup of patients for antibody responses to the pandemic and seasonal influenza A viruses. Results: Secondary attack rates (as confirmed on RT-PCR assay) among household contacts of index patients were similar for the pandemic influenza virus (8%; 95% confidence interval [CI], 3 to 14) and seasonal influenza viruses (9%; 95% CI, 5 to 15). The patterns of viral shedding and the course of illness among index patients were also similar for the pandemic and seasonal influenza viruses. In a subgroup of patients for whom baseline and convalescent serum samples were available, 36% of household contacts who had serologic evidence of pandemic influenza virus infection did not shed detectable virus or report illness. Conclusions: Pandemic 2009 H1N1 virus has characteristics that are broadly similar to those of seasonal influenza A viruses in terms of rates of viral shedding, clinical illness, and transmissibility in the household setting. Copyright © 2010 Massachusetts Medical Society. All rights reserved.en_HK
dc.languageeng-
dc.publisherMassachusetts Medical Society. The Journal's web site is located at http://content.nejm.org/en_HK
dc.relation.ispartofNew England Journal of Medicineen_HK
dc.rightsNew England Journal of Medicine. Copyright © Massachusetts Medical Society.-
dc.subject.meshAntibodies, Viral - blood-
dc.subject.meshDisease Outbreaks-
dc.subject.meshInfluenza A Virus, H1N1 Subtype - genetics - immunology - isolation and purification-
dc.subject.meshInfluenza A virus - genetics - immunology - isolation and purification-
dc.subject.meshInfluenza, Human - epidemiology - transmission - virology-
dc.titleComparative epidemiology of pandemic and seasonal influenza A in householdsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-4793&volume=362&issue=23&spage=2175&epage=2184&date=2010&atitle=Comparative+epidemiology+of+pandemic+and+seasonal+Influenza+A+in+households-
dc.identifier.emailCowling, BJ: bcowling@hku.hken_HK
dc.identifier.emailLeung, GM: gmleung@hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityCowling, BJ=rp01326en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1056/NEJMoa0911530en_HK
dc.identifier.pmid20558368-
dc.identifier.scopuseid_2-s2.0-77953517378en_HK
dc.identifier.hkuros170926-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953517378&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume362en_HK
dc.identifier.issue23en_HK
dc.identifier.spage2175en_HK
dc.identifier.epage2184en_HK
dc.identifier.isiWOS:000278551500006-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridCowling, BJ=8644765500en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridFang, VJ=24474130400en_HK
dc.identifier.scopusauthoridLau, LLH=36010688600en_HK
dc.identifier.scopusauthoridSo, HC=36172147200en_HK
dc.identifier.scopusauthoridFung, ROP=24474481300en_HK
dc.identifier.scopusauthoridMa, ESK=24725277400en_HK
dc.identifier.scopusauthoridKwong, ASK=25640263800en_HK
dc.identifier.scopusauthoridChan, CW=23395800600en_HK
dc.identifier.scopusauthoridTsui, WWS=18038961800en_HK
dc.identifier.scopusauthoridNgai, HY=27467680700en_HK
dc.identifier.scopusauthoridChu, DWS=35108889000en_HK
dc.identifier.scopusauthoridLee, PWY=24474606700en_HK
dc.identifier.scopusauthoridChiu, MC=36171571200en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.citeulike7326269-

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