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Article: Multifunctional yolk-shell nanoparticles: A potential MRI contrast and anticancer agent

TitleMultifunctional yolk-shell nanoparticles: A potential MRI contrast and anticancer agent
Authors
Issue Date2008
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html
Citation
Journal Of The American Chemical Society, 2008, v. 130 n. 35, p. 11828-11833 How to Cite?
AbstractWe report a new type of multifunctional nanomaterials, FePt@Fe 2O 3 yolk-shell nanoparticles, that exhibit high cytotoxicity originated from the FePt yolks and strong MR contrast enhancement resulting from the Fe 2O 3 shells. Encouraged by the recently observed high cytotoxicity of FePt@CoS 2 yolk-shell nanoparticles, we used Fe 2O 3 to replace CoS 2 as the shells to further explore the applications of the yolk-shell nanostructures. The ultralow IC 50 value (238 ± 9 ng of Pt/mL) of FePt@Fe 2O 3 yolk-shell nanoparticles likely originates from the fact that the slow oxidation and release of FePt yolks increases the cytotoxicity. Moreover, compared with two commercial magnetic resonance imaging (MRI) contrast agents, MION and Sinerem, the FePt@Fe 2O 3 yolk-shell nanoparticle showed stronger contrast enhancement according to their apparent transverse relaxivity values (r 2* = 3.462 (μg/mL) -1 s -1). The bifunctional FePt@Fe 2O 3 yolk-shell nanoparticles may serve both as an MRI contrast agent and as a potent anticancer drug. This work indicates that these unique yolk-shell nanoparticles may ultimately lead to new designs of multifunctional nanostructures for nanomedicine. © 2008 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/123833
ISSN
2015 Impact Factor: 13.038
2015 SCImago Journal Rankings: 7.123
ISI Accession Number ID
Funding AgencyGrant Number
RGC (Hong Kong)
HIA (HKUST)
Funding Information:

This work was partially supported by RGC (Hong Kong) and HIA (HKUST).

References

 

DC FieldValueLanguage
dc.contributor.authorGao, Jen_HK
dc.contributor.authorLiang, Gen_HK
dc.contributor.authorCheung, JSen_HK
dc.contributor.authorPan, Yen_HK
dc.contributor.authorKuang, Yen_HK
dc.contributor.authorZhao, Fen_HK
dc.contributor.authorZhang, Ben_HK
dc.contributor.authorZhang, Xen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorXu, Ben_HK
dc.date.accessioned2010-09-30T06:24:43Z-
dc.date.available2010-09-30T06:24:43Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of The American Chemical Society, 2008, v. 130 n. 35, p. 11828-11833en_HK
dc.identifier.issn0002-7863en_HK
dc.identifier.urihttp://hdl.handle.net/10722/123833-
dc.description.abstractWe report a new type of multifunctional nanomaterials, FePt@Fe 2O 3 yolk-shell nanoparticles, that exhibit high cytotoxicity originated from the FePt yolks and strong MR contrast enhancement resulting from the Fe 2O 3 shells. Encouraged by the recently observed high cytotoxicity of FePt@CoS 2 yolk-shell nanoparticles, we used Fe 2O 3 to replace CoS 2 as the shells to further explore the applications of the yolk-shell nanostructures. The ultralow IC 50 value (238 ± 9 ng of Pt/mL) of FePt@Fe 2O 3 yolk-shell nanoparticles likely originates from the fact that the slow oxidation and release of FePt yolks increases the cytotoxicity. Moreover, compared with two commercial magnetic resonance imaging (MRI) contrast agents, MION and Sinerem, the FePt@Fe 2O 3 yolk-shell nanoparticle showed stronger contrast enhancement according to their apparent transverse relaxivity values (r 2* = 3.462 (μg/mL) -1 s -1). The bifunctional FePt@Fe 2O 3 yolk-shell nanoparticles may serve both as an MRI contrast agent and as a potent anticancer drug. This work indicates that these unique yolk-shell nanoparticles may ultimately lead to new designs of multifunctional nanostructures for nanomedicine. © 2008 American Chemical Society.en_HK
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.htmlen_HK
dc.relation.ispartofJournal of the American Chemical Societyen_HK
dc.rightsJournal of the American Chemical Society. Copyright © American Chemical Society.-
dc.subject.meshAnimals-
dc.subject.meshAntineoplastic Agents - chemistry-
dc.subject.meshEgg Shell - chemistry-
dc.subject.meshEgg Yolk - chemistry-
dc.subject.meshNanoparticles - chemistry-
dc.titleMultifunctional yolk-shell nanoparticles: A potential MRI contrast and anticancer agenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-7863&volume=130&issue=35&spage=11828&epage=11833&date=2008&atitle=Multifunctional+yolk-shell+anoparticles:+a+potential+MRI+contrast+and+anticancer+agent-
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ja803920ben_HK
dc.identifier.pmid18681432-
dc.identifier.scopuseid_2-s2.0-51349102982en_HK
dc.identifier.hkuros161910-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-51349102982&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume130en_HK
dc.identifier.issue35en_HK
dc.identifier.spage11828en_HK
dc.identifier.epage11833en_HK
dc.identifier.isiWOS:000258792000052-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGao, J=35487458900en_HK
dc.identifier.scopusauthoridLiang, G=12244977600en_HK
dc.identifier.scopusauthoridCheung, JS=16174280400en_HK
dc.identifier.scopusauthoridPan, Y=11639941100en_HK
dc.identifier.scopusauthoridKuang, Y=8850494400en_HK
dc.identifier.scopusauthoridZhao, F=35235892800en_HK
dc.identifier.scopusauthoridZhang, B=7406905866en_HK
dc.identifier.scopusauthoridZhang, X=36044634000en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.scopusauthoridXu, B=24752310700en_HK

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