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Book Chapter: Role of hepatitis B surface antigen in hepatocarcinogenesis

TitleRole of hepatitis B surface antigen in hepatocarcinogenesis
Authors
Issue Date2005
PublisherElsevier Inc.
Citation
Role of hepatitis B surface antigen in hepatocarcinogenesis. In Hayat, MA (Ed.), Handbook of Immunohistochemistry and In Situ Hybridization of Human Carcinomas, v. 3, p. 229-235. USA: Elsevier Inc., 2005 How to Cite?
AbstractThis chapter discusses the role of hepatitis B surface antigen (HBsAg) in hepatocarcinogenesis. Hepatocellular carcinoma (HCC) is one of the most common human malignant neoplasms. It is the fifth most common cancer and the third cause of cancer death in the world. The prognosis of HCC is very poor with or without therapeutic intervention. The overall 5 years survival rate worldwide is estimated at only ∼3% because of late diagnosis. Although the molecular pathogenesis of HCC remains elusive, the etiologic association between hepatitis B virus (HBV) infection and hepatocarcinogenesis has been well established. There are an estimated 387 million HBV carriers worldwide, and geographic distribution of HBV carriers match well with HCC incidences. Epidemiologic studies have demonstrated that the risk of developing HCC among HBV carriers is 100 fold higher than among noncarriers and the death rate from HCC is between 10% and 25%. The HBsAg polypeptides are important for HBV infection and are an important target for diagnosis and vaccine development.
Persistent Identifierhttp://hdl.handle.net/10722/123264
ISBN
ISSN
2008 SCImago Journal Rankings: 0.100
References

 

DC FieldValueLanguage
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorLau, BSHen_HK
dc.contributor.authorWang, Yen_HK
dc.date.accessioned2010-09-26T11:58:22Z-
dc.date.available2010-09-26T11:58:22Z-
dc.date.issued2005en_HK
dc.identifier.citationRole of hepatitis B surface antigen in hepatocarcinogenesis. In Hayat, MA (Ed.), Handbook of Immunohistochemistry and In Situ Hybridization of Human Carcinomas, v. 3, p. 229-235. USA: Elsevier Inc., 2005-
dc.identifier.isbn978-0-12-088404-9-
dc.identifier.issn1874-5784-
dc.identifier.urihttp://hdl.handle.net/10722/123264-
dc.description.abstractThis chapter discusses the role of hepatitis B surface antigen (HBsAg) in hepatocarcinogenesis. Hepatocellular carcinoma (HCC) is one of the most common human malignant neoplasms. It is the fifth most common cancer and the third cause of cancer death in the world. The prognosis of HCC is very poor with or without therapeutic intervention. The overall 5 years survival rate worldwide is estimated at only ∼3% because of late diagnosis. Although the molecular pathogenesis of HCC remains elusive, the etiologic association between hepatitis B virus (HBV) infection and hepatocarcinogenesis has been well established. There are an estimated 387 million HBV carriers worldwide, and geographic distribution of HBV carriers match well with HCC incidences. Epidemiologic studies have demonstrated that the risk of developing HCC among HBV carriers is 100 fold higher than among noncarriers and the death rate from HCC is between 10% and 25%. The HBsAg polypeptides are important for HBV infection and are an important target for diagnosis and vaccine development.-
dc.languageengen_HK
dc.publisherElsevier Inc.en_HK
dc.relation.ispartofHandbook of Immunohistochemistry and In Situ Hybridization of Human Carcinomas-
dc.titleRole of hepatitis B surface antigen in hepatocarcinogenesisen_HK
dc.typeBook_Chapteren_HK
dc.identifier.emailGuan, XY: xyguan@hkucc.hku.hken_HK
dc.identifier.emailLau, BSH: bshlau@HKUCC.hku.hk-
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1874-5784(05)80028-5-
dc.identifier.scopuseid_2-s2.0-67649386203-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649386203&selection=ref&src=s&origin=recordpage-
dc.identifier.volume3en_HK
dc.identifier.spage229en_HK
dc.identifier.epage235en_HK
dc.publisher.placeUSA-

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