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Article: Involvement of cAMP in neuronal survival and axonal regeneration

TitleInvolvement of cAMP in neuronal survival and axonal regeneration
Authors
Issue Date2004
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ASI
Citation
Anatomical Science International, 2004, v. 79 n. 4, p. 209-212 How to Cite?
AbstractIn vitro, cAMP elevation alters neuronal responsiveness to diffusible growth factors and overcomes myelin-associated inhibitory molecules. Significant advances have been made recently in understanding the role of increases in cAMP in promoting axonal growth. Importantly, it has now been shown that cAMP elevation can promote axonal regeneration and functional recovery after central nervous system injury. Elevation of cAMP can be achieved via either direct application of cAMP analogs or an inhibitor of the enzyme phosphodiesterase that degrades cAMP in vivo. Current information points to a number of protein kinase A-mediated pathways (mitogen-activated protein kinase/extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/akt pathway activation and Rho inactivation) underlying cAMP elevation-induced neuronal survival and axonal regeneration.
Persistent Identifierhttp://hdl.handle.net/10722/117943
ISSN
2015 Impact Factor: 0.861
2015 SCImago Journal Rankings: 0.301
References

 

DC FieldValueLanguage
dc.contributor.authorCui, Qen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-09-26T07:41:14Z-
dc.date.available2010-09-26T07:41:14Z-
dc.date.issued2004en_HK
dc.identifier.citationAnatomical Science International, 2004, v. 79 n. 4, p. 209-212en_HK
dc.identifier.issn1447-6959en_HK
dc.identifier.urihttp://hdl.handle.net/10722/117943-
dc.description.abstractIn vitro, cAMP elevation alters neuronal responsiveness to diffusible growth factors and overcomes myelin-associated inhibitory molecules. Significant advances have been made recently in understanding the role of increases in cAMP in promoting axonal growth. Importantly, it has now been shown that cAMP elevation can promote axonal regeneration and functional recovery after central nervous system injury. Elevation of cAMP can be achieved via either direct application of cAMP analogs or an inhibitor of the enzyme phosphodiesterase that degrades cAMP in vivo. Current information points to a number of protein kinase A-mediated pathways (mitogen-activated protein kinase/extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/akt pathway activation and Rho inactivation) underlying cAMP elevation-induced neuronal survival and axonal regeneration.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ASIen_HK
dc.relation.ispartofAnatomical Science Internationalen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntimicrobial Cationic Peptides - metabolismen_HK
dc.subject.meshAxons - metabolismen_HK
dc.subject.meshCathelicidinsen_HK
dc.subject.meshCell Survival - physiologyen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshHumansen_HK
dc.subject.meshNerve Regeneration - physiologyen_HK
dc.titleInvolvement of cAMP in neuronal survival and axonal regenerationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1447-6959&volume=79&issue=4&spage=209&epage=212&date=2004&atitle=Involvement+of+cAMP+in+neuronal+survival+and+axonal+regenerationen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid15633459-
dc.identifier.scopuseid_2-s2.0-10944220829en_HK
dc.identifier.hkuros96918en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10944220829&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume79en_HK
dc.identifier.issue4en_HK
dc.identifier.spage209en_HK
dc.identifier.epage212en_HK
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridCui, Q=7103080164en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK

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