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Conference Paper: Secretin: A potential neurosecretory factor regulating body water homeostasis.

TitleSecretin: A potential neurosecretory factor regulating body water homeostasis.
Authors
Issue Date2007
PublisherHumana Press, Inc.
Citation
The 8th International Symposium on VIP, PACAP and Related Peptides, Manchester/Burlington, VT., 3-8 September 2007. In Journal of Molecular Neuroscience, 2007, v. 33 n. 3, p. 319-320 How to Cite?
AbstractSecretin, originally isolated from the upper intestinal mucosal extract, is a classical gastrointestinal hormone that has recently implicated to play a neuromodulatory role in higher centers, including cerebellumand hippocampus. On the other hand, its functions in the hypothalamo-neurohypophysial axis have not fully appreciated. Using secretin receptor-null (SCTR−/−) mice, we showed previously that secretin exerts peripheral functions in the kidney, where it modulates the process of renal water reabsorption by stimulating the expression and trafficking of aquaporin-2. Now, we provide evidence to show the activity of secretin at the hypothalamo-pituitary level to regulate body water homeostasis by demonstrating (1) the presence of secretin and its receptor in the hypothalamo-neurohypophysial axis; (2) secretin-induced activation of cfos and vasopressin (Vp) expression in the magnocellular neurons within Paraventricular (PVN) and Supraoptic Nuclei (SON); (3) the in vitro and in vivo stimulatory effects of secretin on Vp secretion; (4) augmentations of secretin and its receptor expression in the hypothalamus and pituitary under water deprivation; (5) TTX- and Cd2+-dependent release of secretin from the posterior pituitary during plasma hyperosmolality; and (6) electrical stimulation of SON and PVN led to a pulsatile release of secretin in peripheral circulation measured in the jugular vein. Taken together, these results revealed that secretin is a novel neurosecretory hormone from the neurohypophysis to modulate body fluid and electrolyte homeostasis.
DescriptionAkira Arimura Young Investigator Award Lecture
pp. 305-347 of this journal issue entitled: Abstracts of the 8th International Symposium on VIP, PACAP and Related Peptides
Persistent Identifierhttp://hdl.handle.net/10722/114885
ISSN
2015 Impact Factor: 2.352
2015 SCImago Journal Rankings: 0.988

 

DC FieldValueLanguage
dc.contributor.authorChu, JYSen_HK
dc.contributor.authorLee, TOen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-09-26T05:20:20Z-
dc.date.available2010-09-26T05:20:20Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 8th International Symposium on VIP, PACAP and Related Peptides, Manchester/Burlington, VT., 3-8 September 2007. In Journal of Molecular Neuroscience, 2007, v. 33 n. 3, p. 319-320en_HK
dc.identifier.issn0895-8696en_HK
dc.identifier.urihttp://hdl.handle.net/10722/114885-
dc.descriptionAkira Arimura Young Investigator Award Lecture-
dc.descriptionpp. 305-347 of this journal issue entitled: Abstracts of the 8th International Symposium on VIP, PACAP and Related Peptides-
dc.description.abstractSecretin, originally isolated from the upper intestinal mucosal extract, is a classical gastrointestinal hormone that has recently implicated to play a neuromodulatory role in higher centers, including cerebellumand hippocampus. On the other hand, its functions in the hypothalamo-neurohypophysial axis have not fully appreciated. Using secretin receptor-null (SCTR−/−) mice, we showed previously that secretin exerts peripheral functions in the kidney, where it modulates the process of renal water reabsorption by stimulating the expression and trafficking of aquaporin-2. Now, we provide evidence to show the activity of secretin at the hypothalamo-pituitary level to regulate body water homeostasis by demonstrating (1) the presence of secretin and its receptor in the hypothalamo-neurohypophysial axis; (2) secretin-induced activation of cfos and vasopressin (Vp) expression in the magnocellular neurons within Paraventricular (PVN) and Supraoptic Nuclei (SON); (3) the in vitro and in vivo stimulatory effects of secretin on Vp secretion; (4) augmentations of secretin and its receptor expression in the hypothalamus and pituitary under water deprivation; (5) TTX- and Cd2+-dependent release of secretin from the posterior pituitary during plasma hyperosmolality; and (6) electrical stimulation of SON and PVN led to a pulsatile release of secretin in peripheral circulation measured in the jugular vein. Taken together, these results revealed that secretin is a novel neurosecretory hormone from the neurohypophysis to modulate body fluid and electrolyte homeostasis.-
dc.languageengen_HK
dc.publisherHumana Press, Inc.en_HK
dc.relation.ispartofJournal of Molecular Neuroscienceen_HK
dc.rightsJournal of Molecular Neuroscience. Rights © Humana Press, Inc..-
dc.titleSecretin: A potential neurosecretory factor regulating body water homeostasis.en_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0895-8696&volume=33&issue=3&spage=319&epage=320&date=2007&atitle=Secretin:+A+potential+neurosecretory+factor+regulating+body+water+homeostasis.en_HK
dc.identifier.emailChu, JYS: hitan@graduate.hku.hken_HK
dc.identifier.emailLee, TO: ltolee2@hkucc.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hkusua.hku.hken_HK
dc.identifier.authorityChu, JYS=rp00684en_HK
dc.identifier.authorityLee, TO=rp00727en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.identifier.hkuros157542en_HK
dc.identifier.volume33en_HK
dc.identifier.issue3en_HK
dc.identifier.spage319en_HK
dc.identifier.epage320en_HK

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