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Conference Paper: Immunomodulation Induced By Chinese Medicine Herb, Rhodiola algida, On Th1- and Th2-dependent Cytokine Production

TitleImmunomodulation Induced By Chinese Medicine Herb, Rhodiola algida, On Th1- and Th2-dependent Cytokine Production
Authors
Issue Date2008
PublisherMary Ann Liebert, Inc.
Citation
The 3rd International Congress on Complementary Medicine Research, Sydney, Australia, 29-31 March 2008. In Journal of Alternative and Complementary Medicine, 2008, v. 14 n. S1, p. S-52 Abstract no. 182 How to Cite?
AbstractRecent developments has shown that the Rhodiola plant has potent adaptogenic, cardioprotective, hepatoprotective, immune enhancing activities and immunomodulatory activity. Rhodiola algida (R. algida) is one of most effective species of Rhodiola and has clinically proven potential in enhancing human immune responses. However, its underlying mechanism in immunomodulation is still unclear. Although immunomodulatory Chinese Medicinal herbs have been used extensively in basic research or clinic, there are still many problems that hinder its popularity in the world. This is because of 1) a lack of proper quality control and 2) obscure biological mechanisms have seriously limited their further development. The current study provides a quantitative assay for the marker compound, salidroside, in an R. algida extract for ensuring the extraction method used in the following experiments. It suggests that the HPLC method used for quantitative assay is simple, quick and reliable. Biological assay indicated that R. algida stimulates human peripheral blood lymphocytes and the underlying immunomodulating effects might be through its regulation of IL-2 in Th1 cells and IL-4, IL-6, IL-10 in Th2 cells. In summary, R. algida is a Chinese herb with potential to regulate human immune responses through modulating both Th1 and Th2 immunities. The findings may enable us to further explain the pharmacological properties in clinic and make R. algida a very promising immunomodulating agent.
Persistent Identifierhttp://hdl.handle.net/10722/114436
ISSN
2015 Impact Factor: 1.395
2015 SCImago Journal Rankings: 0.475

 

DC FieldValueLanguage
dc.contributor.authorLi, Hen_HK
dc.contributor.authorSze, CWen_HK
dc.contributor.authorTong, Yen_HK
dc.date.accessioned2010-09-26T05:00:22Z-
dc.date.available2010-09-26T05:00:22Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 3rd International Congress on Complementary Medicine Research, Sydney, Australia, 29-31 March 2008. In Journal of Alternative and Complementary Medicine, 2008, v. 14 n. S1, p. S-52 Abstract no. 182-
dc.identifier.issn1075-5535-
dc.identifier.urihttp://hdl.handle.net/10722/114436-
dc.description.abstractRecent developments has shown that the Rhodiola plant has potent adaptogenic, cardioprotective, hepatoprotective, immune enhancing activities and immunomodulatory activity. Rhodiola algida (R. algida) is one of most effective species of Rhodiola and has clinically proven potential in enhancing human immune responses. However, its underlying mechanism in immunomodulation is still unclear. Although immunomodulatory Chinese Medicinal herbs have been used extensively in basic research or clinic, there are still many problems that hinder its popularity in the world. This is because of 1) a lack of proper quality control and 2) obscure biological mechanisms have seriously limited their further development. The current study provides a quantitative assay for the marker compound, salidroside, in an R. algida extract for ensuring the extraction method used in the following experiments. It suggests that the HPLC method used for quantitative assay is simple, quick and reliable. Biological assay indicated that R. algida stimulates human peripheral blood lymphocytes and the underlying immunomodulating effects might be through its regulation of IL-2 in Th1 cells and IL-4, IL-6, IL-10 in Th2 cells. In summary, R. algida is a Chinese herb with potential to regulate human immune responses through modulating both Th1 and Th2 immunities. The findings may enable us to further explain the pharmacological properties in clinic and make R. algida a very promising immunomodulating agent.-
dc.languageengen_HK
dc.publisherMary Ann Liebert, Inc.-
dc.relation.ispartofJournal of Alternative and Complementary Medicineen_HK
dc.titleImmunomodulation Induced By Chinese Medicine Herb, Rhodiola algida, On Th1- and Th2-dependent Cytokine Productionen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLi, H: haixiali300@hotmail.comen_HK
dc.identifier.emailSze, CW: stephens@hku.hken_HK
dc.identifier.emailTong, Y: tongyao@hkucc.hku.hken_HK
dc.identifier.authorityTong, Y=rp00509en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1089/acm.2008.ISCMR.1-
dc.identifier.pmid18399784-
dc.identifier.hkuros141895en_HK

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