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Conference Paper: Spontaneous Growth in Chinese Patients with Turner's Syndrome

TitleSpontaneous Growth in Chinese Patients with Turner's Syndrome
Authors
Issue Date1996
PublisherMedcom Limited.
Citation
The 1st Joint Scientific Meeting of Hong Kong College of Paediatricians and Guangdong Pediatric Society of the Chinese Medical Association, Hong Kong, 25 May 1996. In Hong Kong Journal of Paediatrics, 1996, v. 1 n. 2, p. 216 How to Cite?
AbstractAIM: To study the spontaneous growth of Chinese girls with Turner's Syndrome (TS). PATIENTS AND METHODS: The records of 203 patients with TS and age of diagnosis ranging from 0 to 42 years were reviewed. Only height measurements before treatment were included in the analysis and serial height measurements were available in the younger patients. Only one observation was included per year and per child and a total of 858 observations from the basis of the study. The mean and SD values were separately fitted by a second degree polynomial function giving smoothed growth curves. RESULT: 42.0% of the patients had the XO karyotype. The frequencies of other karyotypes includes 45 XO/46XiXq (16.3%), 46XiXq (8.4%), 45XO/46XY (5.91%), 45XO/46XX (5.94%), other 45XO mosaics (5.45%), 46Xdel(Xq) (2.97%), 45XO/46 XY+marker (2.95%), and others (9.9%) The number of observations ranged from 25 at the age of 2 years to 100 at 20 years of age. The mean heights at 3, 10 and 17 years of age in Chinese TS girls were 85.7±1.8, 122.1±5.9 and 139.1±6 3 cm as compared to 87.6±3.4, 122.5±5.0 and 142.3±6.1 cm in Northern Europe TS girls of similar ages The mean final height of Hong Kong TS girl is 142 cm which is -3.1 SD below the population mean. Subgroup analysis of different karyotypes showed that patients with 46XiXq were significantly shorter whereas patients with 45XO/46XY and 46Xdel (Xq) were significantly taller among this study cohort. Turner patients who were disomic for Xp are significantly taller than patients who were monosomic for Xp. CONCLUSION: Chinese TS girls in Hong Kong achieved a final height between that observed in Swedish (147 cm) and Japan (139 cm). The karyotype can have a significant effect on the growth and stature of children with TS.
Persistent Identifierhttp://hdl.handle.net/10722/113859
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123

 

DC FieldValueLanguage
dc.contributor.authorKwan, EYWen_HK
dc.contributor.authorSham, Cen_HK
dc.contributor.authorKarlberg, JPEen_HK
dc.contributor.authorTang, GWKen_HK
dc.contributor.authorPang, Hen_HK
dc.contributor.authorTse, Wen_HK
dc.contributor.authorBut, Ben_HK
dc.contributor.authorYu, CMen_HK
dc.contributor.authorLam, Sen_HK
dc.contributor.authorLow, LCKen_HK
dc.date.accessioned2010-09-26T04:34:19Z-
dc.date.available2010-09-26T04:34:19Z-
dc.date.issued1996en_HK
dc.identifier.citationThe 1st Joint Scientific Meeting of Hong Kong College of Paediatricians and Guangdong Pediatric Society of the Chinese Medical Association, Hong Kong, 25 May 1996. In Hong Kong Journal of Paediatrics, 1996, v. 1 n. 2, p. 216en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/113859-
dc.description.abstractAIM: To study the spontaneous growth of Chinese girls with Turner's Syndrome (TS). PATIENTS AND METHODS: The records of 203 patients with TS and age of diagnosis ranging from 0 to 42 years were reviewed. Only height measurements before treatment were included in the analysis and serial height measurements were available in the younger patients. Only one observation was included per year and per child and a total of 858 observations from the basis of the study. The mean and SD values were separately fitted by a second degree polynomial function giving smoothed growth curves. RESULT: 42.0% of the patients had the XO karyotype. The frequencies of other karyotypes includes 45 XO/46XiXq (16.3%), 46XiXq (8.4%), 45XO/46XY (5.91%), 45XO/46XX (5.94%), other 45XO mosaics (5.45%), 46Xdel(Xq) (2.97%), 45XO/46 XY+marker (2.95%), and others (9.9%) The number of observations ranged from 25 at the age of 2 years to 100 at 20 years of age. The mean heights at 3, 10 and 17 years of age in Chinese TS girls were 85.7±1.8, 122.1±5.9 and 139.1±6 3 cm as compared to 87.6±3.4, 122.5±5.0 and 142.3±6.1 cm in Northern Europe TS girls of similar ages The mean final height of Hong Kong TS girl is 142 cm which is -3.1 SD below the population mean. Subgroup analysis of different karyotypes showed that patients with 46XiXq were significantly shorter whereas patients with 45XO/46XY and 46Xdel (Xq) were significantly taller among this study cohort. Turner patients who were disomic for Xp are significantly taller than patients who were monosomic for Xp. CONCLUSION: Chinese TS girls in Hong Kong achieved a final height between that observed in Swedish (147 cm) and Japan (139 cm). The karyotype can have a significant effect on the growth and stature of children with TS.-
dc.languageengen_HK
dc.publisherMedcom Limited.en_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.titleSpontaneous Growth in Chinese Patients with Turner's Syndromeen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=1 &issue=No. 2&spage=216&epage=&date=1996&atitle=Spontaneous+Growth+in+Chinese+Patients+with+Turner%27s+Syndromeen_HK
dc.identifier.emailKwan, EYW: eywkwan@hkucc.hku.hken_HK
dc.identifier.emailKarlberg, JPE: jpekarl@hkucc.hku.hken_HK
dc.identifier.emailTang, GWK: gwktang@hkucc.hku.hken_HK
dc.identifier.emailLow, LCK: lcklow@hkucc.hku.hken_HK
dc.identifier.authorityKarlberg, JPE=rp00400en_HK
dc.identifier.authorityTang, GWK=rp00328en_HK
dc.identifier.authorityLow, LCK=rp00337en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros22434en_HK
dc.identifier.volume1en_HK
dc.identifier.issue2en_HK
dc.identifier.spage216en_HK

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