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Conference Paper: The effect of dietary n-3 fatty acid deficiency on BDNF expression and spatial learning behavior in rats

TitleThe effect of dietary n-3 fatty acid deficiency on BDNF expression and spatial learning behavior in rats
Authors
Issue Date2006
PublisherFederation of American Societies for Experimental Biology
Citation
Experimental Biology 2006, San Francisco, CA, 1-5 April 2006. In The FASEB Journal, 2006, v, 20 n. 5, p. A1002-A1003 How to Cite?
AbstractA growing body of literature indicates that brain derived neurotrophic factor (BDNF) plays an important role in brain development, particularly in learning and memory function. Essential fatty acids are critical nutrients involved in brain development. To investigate the effects of dietary n-3 fatty acid deficiency on brain BDNF expression and its relationship with learning and memory, Sprague Dawley rats were maintained on a semi-purified diet with adequate or deficient n-3 fatty acids for generations. At the third generation, ten pups at four weeks of age from each group were tested for their spatial learning ability using Morris water maze (MWM) test. At the end of the behavioral test, animals were sacrificed and the brain tissues were assayed for BDNF protein and mRNA levels using ELISA and real-time PCR techniques. Compared with the control animals, the levels of BDNF mRNA in the cerebral cortex and the hippocampus were significantly lower (p<0.05) in n-3 fatty acid deficient pups, although the levels of BDNF proteins in the same regions did not significantly differ. During the learning phase, pups from the deficient group performed significantly poorer in MWM test in comparison to the controls (p<0.05), while the long term memory was not affected by the diet. The results of this study indicate that n-3 fatty acid deficiency affects BDNF expression in the brain, and it also impairs the spatial learning and memory ability. The study was partially supported by Hong Kong Research Grants Council.
Persistent Identifierhttp://hdl.handle.net/10722/110608
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorWang, Len_HK
dc.contributor.authorChen, ZYen_HK
dc.contributor.authorXu, RJen_HK
dc.date.accessioned2010-09-26T02:13:13Z-
dc.date.available2010-09-26T02:13:13Z-
dc.date.issued2006en_HK
dc.identifier.citationExperimental Biology 2006, San Francisco, CA, 1-5 April 2006. In The FASEB Journal, 2006, v, 20 n. 5, p. A1002-A1003-
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/110608-
dc.description.abstractA growing body of literature indicates that brain derived neurotrophic factor (BDNF) plays an important role in brain development, particularly in learning and memory function. Essential fatty acids are critical nutrients involved in brain development. To investigate the effects of dietary n-3 fatty acid deficiency on brain BDNF expression and its relationship with learning and memory, Sprague Dawley rats were maintained on a semi-purified diet with adequate or deficient n-3 fatty acids for generations. At the third generation, ten pups at four weeks of age from each group were tested for their spatial learning ability using Morris water maze (MWM) test. At the end of the behavioral test, animals were sacrificed and the brain tissues were assayed for BDNF protein and mRNA levels using ELISA and real-time PCR techniques. Compared with the control animals, the levels of BDNF mRNA in the cerebral cortex and the hippocampus were significantly lower (p<0.05) in n-3 fatty acid deficient pups, although the levels of BDNF proteins in the same regions did not significantly differ. During the learning phase, pups from the deficient group performed significantly poorer in MWM test in comparison to the controls (p<0.05), while the long term memory was not affected by the diet. The results of this study indicate that n-3 fatty acid deficiency affects BDNF expression in the brain, and it also impairs the spatial learning and memory ability. The study was partially supported by Hong Kong Research Grants Council.-
dc.languageengen_HK
dc.publisherFederation of American Societies for Experimental Biology-
dc.relation.ispartofThe FASEB Journalen_HK
dc.titleThe effect of dietary n-3 fatty acid deficiency on BDNF expression and spatial learning behavior in ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.identifier.hkuros120927en_HK

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