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Conference Paper: Actions of secretin on the hypothalamic magnocellular neurons: Implications for the control of body water homostasis

TitleActions of secretin on the hypothalamic magnocellular neurons: Implications for the control of body water homostasis
Authors
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpep
Citation
The 7th International Symposium on VIP, PACAP and Related Peptides, Rouen, France, 11-14 September 2005. In Regulatory Peptides, v. 130 n. 3, p. 159 How to Cite?
AbstractFor the last 100 years, secretin has been extensively studied for its hormonal effects in the gastrointestinal tract. Recent observation by our group that this classical gastrointestinal hormone is readily releasable from hypothalamic neurons upon K+-evoked depolarization suggested a potential influence of this peptide on the neuronal activity within this brain region. We hereby showed that intracerebroventricularly-injected secretin could elevate c-fos and vasopressin (VP) gene expression in the magnocellular subdivision of the Paraventricular Nucleus as well as throughout the Supraoptic Nucleus. In addition, it could also enhance, through a cAMP/PKA-dependent pathway, the basal release of VP from the hypothalamic explants. Together with the fact that secretin is expressed at high concentrations in the circumventricular subfornical organ, which contains osmoreceptor cells that regulate the plasma osmolality, as well as its releasing ability from the somatodendritic and axonal compartments of the magnocellular neurons via a TTX-sensitive and Ca2+-dependent mechanism, it is speculated that locally released secretin in the hypothalamo– neurohypophysial system could act in autocrine and/or paracrine manners via its G protein-coupled receptor to modulate osmoregulation.
Descriptionpp. 133-188 of this journal issue entitled: Abstracts of the 7th International Symposium on VIP, PACAP and Related Peptides. Rouen, France. September 11-14, 2005
Persistent Identifierhttp://hdl.handle.net/10722/110330
ISSN
2015 Impact Factor: 1.813
2015 SCImago Journal Rankings: 0.915

 

DC FieldValueLanguage
dc.contributor.authorChu, JYSen_HK
dc.contributor.authorYung, WHen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-09-26T02:01:16Z-
dc.date.available2010-09-26T02:01:16Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 7th International Symposium on VIP, PACAP and Related Peptides, Rouen, France, 11-14 September 2005. In Regulatory Peptides, v. 130 n. 3, p. 159en_HK
dc.identifier.issn0167-0115en_HK
dc.identifier.urihttp://hdl.handle.net/10722/110330-
dc.descriptionpp. 133-188 of this journal issue entitled: Abstracts of the 7th International Symposium on VIP, PACAP and Related Peptides. Rouen, France. September 11-14, 2005-
dc.description.abstractFor the last 100 years, secretin has been extensively studied for its hormonal effects in the gastrointestinal tract. Recent observation by our group that this classical gastrointestinal hormone is readily releasable from hypothalamic neurons upon K+-evoked depolarization suggested a potential influence of this peptide on the neuronal activity within this brain region. We hereby showed that intracerebroventricularly-injected secretin could elevate c-fos and vasopressin (VP) gene expression in the magnocellular subdivision of the Paraventricular Nucleus as well as throughout the Supraoptic Nucleus. In addition, it could also enhance, through a cAMP/PKA-dependent pathway, the basal release of VP from the hypothalamic explants. Together with the fact that secretin is expressed at high concentrations in the circumventricular subfornical organ, which contains osmoreceptor cells that regulate the plasma osmolality, as well as its releasing ability from the somatodendritic and axonal compartments of the magnocellular neurons via a TTX-sensitive and Ca2+-dependent mechanism, it is speculated that locally released secretin in the hypothalamo– neurohypophysial system could act in autocrine and/or paracrine manners via its G protein-coupled receptor to modulate osmoregulation.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpepen_HK
dc.relation.ispartofRegulatory Peptidesen_HK
dc.rightsRegulatory Peptides. Copyright © Elsevier BV.en_HK
dc.titleActions of secretin on the hypothalamic magnocellular neurons: Implications for the control of body water homostasisen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0167-0115&volume=130&issue=3&spage=159&epage=&date=2006&atitle=Actions+of+secretin+on+the+hypothalamic+magnocellular+neurons:+Implications+for+the+control+of+body+water+homostasisen_HK
dc.identifier.emailChu, JYS: hitan@graduate.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hkusua.hku.hken_HK
dc.identifier.authorityChu, JYS=rp00684en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.regpep.2005.06.011-
dc.identifier.hkuros103383en_HK
dc.identifier.hkuros123308-
dc.identifier.volume130en_HK
dc.identifier.issue3en_HK
dc.identifier.issue3-
dc.identifier.spage159en_HK
dc.identifier.epage159-

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