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Conference Paper: Aging and response regulation as revealed by functional MRI

TitleAging and response regulation as revealed by functional MRI
Authors
Issue Date2004
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
The 10th International Conference on Functional Mapping of the Human Brain (OHBM 2004), Budapest, Hungary, 13-17 June 2004. In NeuroImage, 2004, v. 22 suppl. 1, p. e2007, abstarct no. TH 74 How to Cite?
AbstractResponse regulation involves freeing oneself from habitual reactions to produce goal-relevant behaviors. The cognitive control of which is implemented by a distributed network comprising closely interacting yet anatomically dissociable components. Much behavioral data concerning inhibitory decline in aging has been reported. Age-related changes in neural activation, in terms of volume and/or pattern of activation during response regulation, however, remain unclear. We therefore employed functional magnetic resonance imaging (fMRI) technology to study the differences in voxel activation and lateralization patterns of neural activation between middle-aged and younger adults. Twenty-six subjects belonging to two groups, specifically a younger group and a middle-aged group (the mean ages of which were 22.62 and 47.68 years respectively), were administered an experimental task developed for this study which measured response regulation. There were two conditions in this task, namely the Go and the Reverse conditions. During the Go condition, the subject was required to read the direction of arrowheads. This was followed by the Reverse condition, in which the subject was first required to identify the direction of the arrowhead and then give the opposite answer, so that an up arrow should elicit a down response, and vice versa. The experiment was performed on a 1.5-T Magnetom Vision MRI scanner (Siemens, Erlangen, Germany). A single shot, T2*-weighted gradient-echo planar imaging (EPI) sequence was used for the fMRI scans (slice thickness = 5mm, in-plane resolution = 3.3 X 3.3mm, TR/TE/θ = 3000ms/60 ms/90o ). The imaging data indicated activation of a frontal (middle frontal gyrus) and cingulate (anterior cingulate region) circuit in both groups, when subjects were engaged in response regulation. At the subcortical level, activity of the right thalamus in the younger group, and of the left lentiform nucleus in the middle-aged group, was observed. For the frontal activation, the results of the lateralization index calculation indicated that the activation of older adults was more left lateralized than that of the young, when performing the same experimental task of response regulation. The findings suggested that possible age-related differences in response regulation between the middle-aged and younger adults.
DescriptionSession: Cognition & Attention
This journal suppl. entitled: Abstracts presented at the 10th International Conference on Functional Mapping of the Human Brain ... 2004
Persistent Identifierhttp://hdl.handle.net/10722/110106
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464

 

DC FieldValueLanguage
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorLiu, HLen_HK
dc.contributor.authorYuen, KSLen_HK
dc.contributor.authorFang, SYen_HK
dc.contributor.authorChan, CCHen_HK
dc.date.accessioned2010-09-26T01:51:25Z-
dc.date.available2010-09-26T01:51:25Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 10th International Conference on Functional Mapping of the Human Brain (OHBM 2004), Budapest, Hungary, 13-17 June 2004. In NeuroImage, 2004, v. 22 suppl. 1, p. e2007, abstarct no. TH 74-
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/110106-
dc.descriptionSession: Cognition & Attention-
dc.descriptionThis journal suppl. entitled: Abstracts presented at the 10th International Conference on Functional Mapping of the Human Brain ... 2004-
dc.description.abstractResponse regulation involves freeing oneself from habitual reactions to produce goal-relevant behaviors. The cognitive control of which is implemented by a distributed network comprising closely interacting yet anatomically dissociable components. Much behavioral data concerning inhibitory decline in aging has been reported. Age-related changes in neural activation, in terms of volume and/or pattern of activation during response regulation, however, remain unclear. We therefore employed functional magnetic resonance imaging (fMRI) technology to study the differences in voxel activation and lateralization patterns of neural activation between middle-aged and younger adults. Twenty-six subjects belonging to two groups, specifically a younger group and a middle-aged group (the mean ages of which were 22.62 and 47.68 years respectively), were administered an experimental task developed for this study which measured response regulation. There were two conditions in this task, namely the Go and the Reverse conditions. During the Go condition, the subject was required to read the direction of arrowheads. This was followed by the Reverse condition, in which the subject was first required to identify the direction of the arrowhead and then give the opposite answer, so that an up arrow should elicit a down response, and vice versa. The experiment was performed on a 1.5-T Magnetom Vision MRI scanner (Siemens, Erlangen, Germany). A single shot, T2*-weighted gradient-echo planar imaging (EPI) sequence was used for the fMRI scans (slice thickness = 5mm, in-plane resolution = 3.3 X 3.3mm, TR/TE/θ = 3000ms/60 ms/90o ). The imaging data indicated activation of a frontal (middle frontal gyrus) and cingulate (anterior cingulate region) circuit in both groups, when subjects were engaged in response regulation. At the subcortical level, activity of the right thalamus in the younger group, and of the left lentiform nucleus in the middle-aged group, was observed. For the frontal activation, the results of the lateralization index calculation indicated that the activation of older adults was more left lateralized than that of the young, when performing the same experimental task of response regulation. The findings suggested that possible age-related differences in response regulation between the middle-aged and younger adults.-
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.titleAging and response regulation as revealed by functional MRIen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-8119&volume=&spage=&epage=&date=2004&atitle=Aging+and+response+regulation+as+revealed+by+functional+MRIen_HK
dc.identifier.emailLee, TMC: tmclee@hkusua.hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1053-8119(05)70019-7-
dc.identifier.hkuros102164en_HK
dc.identifier.volume22-
dc.identifier.issuesuppl. 1-
dc.identifier.spagee2007, abstarct no. TH 74-
dc.identifier.epagee2007, abstarct no. TH 74-

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