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Conference Paper: A decade of right liver adult-to-adult live donor liver transplantation: mid-term outcomes

TitleA decade of right liver adult-to-adult live donor liver transplantation: mid-term outcomes
Authors
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. How to Cite?
AbstractIntroduction Right liver adult-to-adult live donor liver transplantation debuted a decade ago is now due for mid-term outcomes appraisal. Patients and methods Consecutive liver transplant cases with a minimum follow-up of 2 years in Queen Mary Hospital, the University of Hong Kong from May 1996 to December 2004 were included (N=188). The data including recipient and graft characteristics were collected prospectively and were analyzed retrospectively. From 1996 to 2000, fewer than 30 cases per year were determined early era. Results This series had a median followup of 48 months. The early era included 28 cases and the latter era 160 cases. Recipients of the early era were slightly younger (42 yr vs. 48 yr, p = 0.002) and fewer of them suffered from hepatocellular carcinoma (HCC) (10.7% vs. 29.4%, p = 0.039). Disease severity was worse as refl ected by a higher proportion of recipients with hepatorenal syndrome (35.7% vs. 16.3%, p = 0.016), and higher Model of End-stage Liver Disease scores (34 vs. 26, p = 0.007). Graft characteristics were similar. The recipients of the early era had higher hospital mortalities (6/28 vs. 4/160, p = 0.001). Transplantation in the high urgency situation did not result in higher hospital mortality (5/91 vs. 5/97, p = 0.917). None of the recipients transplanted for HCC had hospital mortality (0/50 vs. 10/138, p= 0.065). On univariate analysis, the presence of HCC and transplantation in the early era were of adverse factors for survival. This was verifi ed by a multivariate analysis which indicated that early era (RR = 2.824, p = 0.015) and HCC (RR = 2.897, p = 0.005) were factors adversely affecting overall survival. The 1-, 3-, and 5-year overall survivals were 92.5%, 86.3%, and 82.3%, respectively. When recipients with hospital mortality and transplanted for HCC were excluded, the 1-, 3-, and 5-year overall survivals became 97.6%, 95.3%, and 95.3%, respectively. Recipients with HCC (n = 50) and only those who were within the Milan criteria (n = 34) had 1-, 3-, and 5-year survivals of 98.0%, 80.5%, and 63.4%; and 97.1%, 85.0%, and, 67.6%, respectively. Conclusion This operation resulted in predictably high 5-year survival in particular when hospital mortality could be avoided after maturation of techniques and careful case selection of recipients with a low chance of recurrence from HCC.
Persistent Identifierhttp://hdl.handle.net/10722/108393
ISSN
2015 Impact Factor: 3.951
2015 SCImago Journal Rankings: 1.763

 

DC FieldValueLanguage
dc.contributor.authorChan, SCen_HK
dc.contributor.authorChik, Ben_HK
dc.contributor.authorLiu, CLen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-26T00:37:46Z-
dc.date.available2010-09-26T00:37:46Z-
dc.date.issued2007en_HK
dc.identifier.citationThe International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007.-
dc.identifier.issn1527-6465-
dc.identifier.urihttp://hdl.handle.net/10722/108393-
dc.description.abstractIntroduction Right liver adult-to-adult live donor liver transplantation debuted a decade ago is now due for mid-term outcomes appraisal. Patients and methods Consecutive liver transplant cases with a minimum follow-up of 2 years in Queen Mary Hospital, the University of Hong Kong from May 1996 to December 2004 were included (N=188). The data including recipient and graft characteristics were collected prospectively and were analyzed retrospectively. From 1996 to 2000, fewer than 30 cases per year were determined early era. Results This series had a median followup of 48 months. The early era included 28 cases and the latter era 160 cases. Recipients of the early era were slightly younger (42 yr vs. 48 yr, p = 0.002) and fewer of them suffered from hepatocellular carcinoma (HCC) (10.7% vs. 29.4%, p = 0.039). Disease severity was worse as refl ected by a higher proportion of recipients with hepatorenal syndrome (35.7% vs. 16.3%, p = 0.016), and higher Model of End-stage Liver Disease scores (34 vs. 26, p = 0.007). Graft characteristics were similar. The recipients of the early era had higher hospital mortalities (6/28 vs. 4/160, p = 0.001). Transplantation in the high urgency situation did not result in higher hospital mortality (5/91 vs. 5/97, p = 0.917). None of the recipients transplanted for HCC had hospital mortality (0/50 vs. 10/138, p= 0.065). On univariate analysis, the presence of HCC and transplantation in the early era were of adverse factors for survival. This was verifi ed by a multivariate analysis which indicated that early era (RR = 2.824, p = 0.015) and HCC (RR = 2.897, p = 0.005) were factors adversely affecting overall survival. The 1-, 3-, and 5-year overall survivals were 92.5%, 86.3%, and 82.3%, respectively. When recipients with hospital mortality and transplanted for HCC were excluded, the 1-, 3-, and 5-year overall survivals became 97.6%, 95.3%, and 95.3%, respectively. Recipients with HCC (n = 50) and only those who were within the Milan criteria (n = 34) had 1-, 3-, and 5-year survivals of 98.0%, 80.5%, and 63.4%; and 97.1%, 85.0%, and, 67.6%, respectively. Conclusion This operation resulted in predictably high 5-year survival in particular when hospital mortality could be avoided after maturation of techniques and careful case selection of recipients with a low chance of recurrence from HCC.-
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021-
dc.relation.ispartofLiver Transplantationen_HK
dc.rightsLiver Transplantation. Copyright © John Wiley & Sons, Inc.-
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.titleA decade of right liver adult-to-adult live donor liver transplantation: mid-term outcomesen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1527-6465&volume=13&issue=Suppl.1&spage=S106 Abstract no. 154&epage=&date=2007&atitle=A+decade+of+right+liver+adult-to-adult+live+donor+liver+transplantation:+mid-term+outcomes+(Abstract)-
dc.identifier.emailChan, SC: chanlsc@HKUCC.hku.hken_HK
dc.identifier.emailLiu, CL: clliu@hkucc.hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.doi10.1002/lt.21269-
dc.identifier.hkuros135538en_HK
dc.identifier.volume13-
dc.identifier.issueSuppl 1-
dc.identifier.spageS106 Abstract no. 154-
dc.identifier.epageS106 Abstract no. 154-

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