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Conference Paper: Clinical significance of serum angiocidin levels in hepatocellular carcinoma

TitleClinical significance of serum angiocidin levels in hepatocellular carcinoma
Authors
Issue Date2005
PublisherAmerican Association for Cancer Research
Citation
AACR 96th Annual Meeting, Anaheim CA, 16–20 April 2005. In Cancer Research, 2005, v. 65 n. 9S, p. 1319 Abstract no. 5603 How to Cite?
AbstractAngiocidin is a TSP-binding protein that was found to be over-expressed in hepatocellular carcinoma (Clinical Cancer Research Vol 10, 4150-4157, 2004). We recently observed that angiocidin is present in the serum of various cancer patients. Patients with hepatocellular carcinoma (HCC) in particular were found to have some of the highest serum levels of angiocidin. In order to evaluate the clinical significance of these results, serum levels of angiocidin in 33 HCC patients were measured. Serum levels of angiocidin were measured using a sensitive capture ELISA able to measure angiocidin levels as low as 0.01 picogram/ml. We found that angiocidin levels were significantly higher in HCC vs controls. Normal healthy controls had undetectable levels of angiocidin below 0.01 pg/ml. In contrast, HCC patients showed significantly elevated levels ranging from 15.09-195.73 pg/ml. Patients with stages III-IV of HCC had statistically higher levels of angiocidin (97±13 pg/ml, n=17) compared to those with stages I-II (63±37 pg/ml, n=16), p<0.043. Similarly, patients with microsatellite tumor nodules had statistically higher average levels of angiocidin (98±55 pg/ml, n=17) compared to those with no tumor nodules (51±27 pg/ml, n=20). Therefore, our studies suggest that serum levels of angiocidin can be used as a marker for HCC as well as predicting stage and intra-hepatic metastases.
Persistent Identifierhttp://hdl.handle.net/10722/108291
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372

 

DC FieldValueLanguage
dc.contributor.authorSabherwal, Yen_HK
dc.contributor.authorRothman, Ven_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorTuszynski, Gen_HK
dc.date.accessioned2010-09-26T00:33:29Z-
dc.date.available2010-09-26T00:33:29Z-
dc.date.issued2005en_HK
dc.identifier.citationAACR 96th Annual Meeting, Anaheim CA, 16–20 April 2005. In Cancer Research, 2005, v. 65 n. 9S, p. 1319 Abstract no. 5603-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/108291-
dc.description.abstractAngiocidin is a TSP-binding protein that was found to be over-expressed in hepatocellular carcinoma (Clinical Cancer Research Vol 10, 4150-4157, 2004). We recently observed that angiocidin is present in the serum of various cancer patients. Patients with hepatocellular carcinoma (HCC) in particular were found to have some of the highest serum levels of angiocidin. In order to evaluate the clinical significance of these results, serum levels of angiocidin in 33 HCC patients were measured. Serum levels of angiocidin were measured using a sensitive capture ELISA able to measure angiocidin levels as low as 0.01 picogram/ml. We found that angiocidin levels were significantly higher in HCC vs controls. Normal healthy controls had undetectable levels of angiocidin below 0.01 pg/ml. In contrast, HCC patients showed significantly elevated levels ranging from 15.09-195.73 pg/ml. Patients with stages III-IV of HCC had statistically higher levels of angiocidin (97±13 pg/ml, n=17) compared to those with stages I-II (63±37 pg/ml, n=16), p<0.043. Similarly, patients with microsatellite tumor nodules had statistically higher average levels of angiocidin (98±55 pg/ml, n=17) compared to those with no tumor nodules (51±27 pg/ml, n=20). Therefore, our studies suggest that serum levels of angiocidin can be used as a marker for HCC as well as predicting stage and intra-hepatic metastases.-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research-
dc.relation.ispartofCancer Researchen_HK
dc.titleClinical significance of serum angiocidin levels in hepatocellular carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.hkuros99806en_HK

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