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Conference Paper: Fibrosis progression in patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation

TitleFibrosis progression in patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation
Authors
Issue Date2006
PublisherWiley-Blackwell Publishing Asia
Citation
Shanghai—Hong Kong International Liver Congress, Shanghai, China, 25–28 March 2006. In Journal of Gastroenterology and Hepatology, 2006, v. 21 n. S2, p. A80-A81 How to Cite?
AbstractBackground & Aim It is uncertain whether occult hepatitis Bvirus (HBV) co-infection will hasten progressive liver disease inchronic hepatitis C virus (HCV) patients post-liver transplantation.We compared fibrosis progression (fibrosis progression by at least 2-stage) and severe fibrosis (fibrosis stage 3 or 4) longitudinally on serialliver biopsies in patients with recurrent chronic HCV infection co-infected with occult HBV post-liver transplantation.Method One-hundred and eighteen consecutive hepatitis B surfaceantigen negative patients with virological and histological evidence ofrecurrent chronic HCV infection within 1-year post-liver transplan-tation were recruited into this study. HBV DNA was detected fromserum at the time of recurrent chronic HCV infection post-transplantation with PCR. Longitudinal liver biopsy was performedevery 3 monthly for the first year after transplantation and then annually until the time of analysis for fibrosis progression.Results Occult HBV co-infection was present in 41 of 118 (34.7%)consecutive patients with recurrent chronic HCV infection post-livertransplantation. At the time of analysis, all patients had undergonemultiple liver biopsies. The median time between the first and finalliver biopsy was 65.6 (range 20.5–89.4) months. Thirteen of the 41occult HBV co-infected patients compared with 16 of the 77 patientswithout occult HBV co-infection developed fibrosis progression(31.7% vs. 20.8% respectively, p = 0.87). Eight of the 41 occult HBVco-infected patients compared with 13 of the 77 patients withoutoccult HBV co-infection had severe fibrosis (19.5% vs. 16.9% respec-tively, p = 0.72). Conclusion Occult HBV co-infection in patients with recurrentchronic HCV infection was not associated with accelerated fibrosisprogression or severe fibrosis post-liver transplantation.
Persistent Identifierhttp://hdl.handle.net/10722/108285
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190

 

DC FieldValueLanguage
dc.contributor.authorHui, CKen_HK
dc.contributor.authorLau, Een_HK
dc.contributor.authorKim, Men_HK
dc.contributor.authorMonto, Aen_HK
dc.contributor.authorLuk, JMCen_HK
dc.contributor.authorLeung, Nen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorWright, TLen_HK
dc.contributor.authorLau, Gen_HK
dc.date.accessioned2010-09-26T00:33:13Z-
dc.date.available2010-09-26T00:33:13Z-
dc.date.issued2006en_HK
dc.identifier.citationShanghai—Hong Kong International Liver Congress, Shanghai, China, 25–28 March 2006. In Journal of Gastroenterology and Hepatology, 2006, v. 21 n. S2, p. A80-A81en_HK
dc.identifier.issn0815-9319-
dc.identifier.urihttp://hdl.handle.net/10722/108285-
dc.description.abstractBackground & Aim It is uncertain whether occult hepatitis Bvirus (HBV) co-infection will hasten progressive liver disease inchronic hepatitis C virus (HCV) patients post-liver transplantation.We compared fibrosis progression (fibrosis progression by at least 2-stage) and severe fibrosis (fibrosis stage 3 or 4) longitudinally on serialliver biopsies in patients with recurrent chronic HCV infection co-infected with occult HBV post-liver transplantation.Method One-hundred and eighteen consecutive hepatitis B surfaceantigen negative patients with virological and histological evidence ofrecurrent chronic HCV infection within 1-year post-liver transplan-tation were recruited into this study. HBV DNA was detected fromserum at the time of recurrent chronic HCV infection post-transplantation with PCR. Longitudinal liver biopsy was performedevery 3 monthly for the first year after transplantation and then annually until the time of analysis for fibrosis progression.Results Occult HBV co-infection was present in 41 of 118 (34.7%)consecutive patients with recurrent chronic HCV infection post-livertransplantation. At the time of analysis, all patients had undergonemultiple liver biopsies. The median time between the first and finalliver biopsy was 65.6 (range 20.5–89.4) months. Thirteen of the 41occult HBV co-infected patients compared with 16 of the 77 patientswithout occult HBV co-infection developed fibrosis progression(31.7% vs. 20.8% respectively, p = 0.87). Eight of the 41 occult HBVco-infected patients compared with 13 of the 77 patients withoutoccult HBV co-infection had severe fibrosis (19.5% vs. 16.9% respec-tively, p = 0.72). Conclusion Occult HBV co-infection in patients with recurrentchronic HCV infection was not associated with accelerated fibrosisprogression or severe fibrosis post-liver transplantation.-
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia-
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.titleFibrosis progression in patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantationen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailHui, CK: ckh23@cam.ac.uken_HK
dc.identifier.emailLuk, JMC: jmluk@hkucc.hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailLau, G: gkklau@netvigator.comen_HK
dc.identifier.authorityLuk, JMC=rp00349en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1746.2006.04403.x-
dc.identifier.hkuros117037en_HK
dc.identifier.hkuros120311-
dc.identifier.volume21en_HK
dc.identifier.issueSuppl 2en_HK
dc.identifier.spageA80en_HK

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