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Conference Paper: In vivo MR imaging of intraportal vein transplantation nanometer magnetically labeled bone marrow mesenchymal stem cells in rat liver

TitleIn vivo MR imaging of intraportal vein transplantation nanometer magnetically labeled bone marrow mesenchymal stem cells in rat liver
Authors
Issue Date2006
PublisherBlackwell Publishing Asia.
Citation
Shanghai—Hong Kong International Liver Congress, Shanghai, China, 25–28 March 2006. In Journal of Gastroenterology and Hepatology, 2006, v. 21 n. S2, p. A209 How to Cite?
AbstractObjective To evaluate in vivo magnetic resonance imaging with aconventional 1.5-T system for tracking of intra-portal vein trans-plantation nanometer magnetically labeled bone marrow mesenchy-mal stem cells (BMSC) in rat liver.Materials and Methods Rat BMSC were labeled with nanome-ter superpara-magnetic iron oxide and transfection agent. Cell label-ing efficiency was assessed with determination of the percentage ofPerls Prussian blue stain. Then BMSC intra-portal vein transplantedinto normal rats’ livers. Follow-up serial T2*-weighted gradient-echoMR imaging were performed at 1.5-T MRI system. MR imaging findings were compared histologically.Results Cell labeling efficiency was more than 95% by Perls Pruss-ian blue stain-positive cells. After labeled BMSC intra-portal veintransplantation, liver had diffuse granular signal intensity appearance.Cell were detected for up to 2 w in liver. At histologic analysis, signalintensity loss correlated with iron-loaded cells.Conclusion MR imaging could aid in monitoring of intra-portalvein administered magnetically labeled BMSC in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/108172
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190

 

DC FieldValueLanguage
dc.contributor.authorWang, Pen_HK
dc.contributor.authorWang, JHen_HK
dc.contributor.authorYan, ZPen_HK
dc.contributor.authorLuk, JMCen_HK
dc.date.accessioned2010-09-26T00:28:29Z-
dc.date.available2010-09-26T00:28:29Z-
dc.date.issued2006en_HK
dc.identifier.citationShanghai—Hong Kong International Liver Congress, Shanghai, China, 25–28 March 2006. In Journal of Gastroenterology and Hepatology, 2006, v. 21 n. S2, p. A209en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/108172-
dc.description.abstractObjective To evaluate in vivo magnetic resonance imaging with aconventional 1.5-T system for tracking of intra-portal vein trans-plantation nanometer magnetically labeled bone marrow mesenchy-mal stem cells (BMSC) in rat liver.Materials and Methods Rat BMSC were labeled with nanome-ter superpara-magnetic iron oxide and transfection agent. Cell label-ing efficiency was assessed with determination of the percentage ofPerls Prussian blue stain. Then BMSC intra-portal vein transplantedinto normal rats’ livers. Follow-up serial T2*-weighted gradient-echoMR imaging were performed at 1.5-T MRI system. MR imaging findings were compared histologically.Results Cell labeling efficiency was more than 95% by Perls Pruss-ian blue stain-positive cells. After labeled BMSC intra-portal veintransplantation, liver had diffuse granular signal intensity appearance.Cell were detected for up to 2 w in liver. At histologic analysis, signalintensity loss correlated with iron-loaded cells.Conclusion MR imaging could aid in monitoring of intra-portalvein administered magnetically labeled BMSC in vivo.-
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia.en_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.titleIn vivo MR imaging of intraportal vein transplantation nanometer magnetically labeled bone marrow mesenchymal stem cells in rat liveren_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0815-9319&volume=21 Supp&spage=A209&epage=A209&date=2006&atitle=In+vivo+MR+imaging+of+intraportal+vein+transplantation+nanometer+magnetically+labeled+bone+marrow+mesenchymal+stem+cells+in+rat+liveren_HK
dc.identifier.emailWang, P: wangping@hkucc.hku.hken_HK
dc.identifier.emailLuk, JMC: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityLuk, JMC=rp00349en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1746.2006.04408.x-
dc.identifier.hkuros137531en_HK
dc.identifier.volume21en_HK
dc.identifier.spage209en_HK
dc.identifier.epage209en_HK

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